Clinical trials: Miscarriages
Miscarriage, Recurrent, Premature Labor
PAR Family Polymorphisms and Placental Invasion Disorders
The present study will be undertaken to establish whether genetic variations of PAR1 could be involved in the occurrence of any of the "placental syndromes" of preterm delivery, preeclampsia, and/or small for gestational age…
- Trial name
- NCT00425867
- Testing
- PAR1 polymoprhisms and placental invasion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Infertility, Aneuploidy
The Effect of Acupuncture on Pregnancy Rates in Women Undergoing in Vitro Fertilization With Preimplantation Genetic Screening
While IVF offers an effective treatment for infertility, a significant proportion of IVF cycles still result in failed implantation and early miscarriage.
- Trial name
- NCT03981120
- Testing
- Laser and Traditional Acupuncture
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Vitamin D Deficiency, Recurrent Miscarriage
The Cohort Study of the Correlation Between Serum 25(OH)D Level and Pregnancy Outcome
The objective of this single-center prospective observational study is to clarify the trend of maternal serum 25(OH)D levels before pregnancy and during pregnancy, and to explore the correlation between serum 25(OH)D levels and…
- Conditions
- Vitamin D Deficiency, Recurrent Miscarriage, Pregnancy Related
- Trial name
- NCT05824897
- Testing
- Serum levels of vitamin D
- Where
- China
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Aimin Zhao
Preeclampsia, Premature Birth
Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes
Objective: This study aims to investigate the association between maternal serum placental growth factor (PLGF) and nucleosome levels in early pregnancy and adverse pregnancy outcomes, and to evaluate their predictive value for…
- Conditions
- Preeclampsia, Premature Birth, Fetal Growth Restriction, Recurrent Miscarriage
- Trial name
- NCT07841197
- Testing
- Measurement of plasma nucleosome and placental growth factor (PLGF) levels
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Recurrent Miscarriages
Maternal Embryo Interaction in Recurrent Miscarriages
Background of the study: The etiology of recurrent miscarriage (RM, defined as three or more consecutive miscarriages without any proven maternal or fetal cause), remains undiagnosed in more than 50% of cases.
- Trial name
- MEER (NCT03156491)
- Where
- Netherlands
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Complete Miscarriage
Use of Letrozole Pretreatment With Misoprostol for First-Trimester Medical Abortion
The purpose of this study is to compare the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.
- Trial name
- NCT02401425
- Testing
- Letrozole, Misoprostol
- Where
- Egypt
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Recurrent Pregnancy Losses
The Role of Uterine NK Cells and T Cell Cytokines in Recurrent Miscarriage
The aim of the study is to evaluate the role of uterine natural killer cell(uNK)in recurrent pregnancy losses and the correlation between the numbers of it and embryo toxicity by measuring the level of the Th2 cytokines in normal…
- Trial name
- NCT01688284
- Testing
- office hysteroscopy
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Miscarriage in First Trimester
Angular Pregnancy - Ultrasound Definition and Correlation With Clinical Outcomes
The aim of this study is to establish clinically meaningful ultrasound-based diagnostic criteria for AP. To this end, the investigators will prospectively collect clinical and ultrasound data from early intrauterine pregnancies…
- Trial name
- NCT06262373
- Testing
- Ultrasound
- Where
- United Kingdom
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Obese, Overweight
Efficacy of a Structured Weight Loss Program in Overweight Women With a History of Recurrent Pregnancy Loss
Overweight and obesity has been associated with a number of adverse pregnancy outcomes in women of reproductive age, including infertility and early pregnancy loss.
- Conditions
- Obese, Overweight, Miscarriage, Recurrent Pregnancy Loss
- Trial name
- NCT01325805
- Testing
- Structured Weight Loss Program, Routine Weight Loss Counseling
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Stanford University
Birth, Spontaneous Abortion
The Effects of Aspirin in Gestation and Reproduction
The primary objective of the study is to help elucidate the effects of low-dose aspirin in combination with folic acid on the incidence of live births and spontaneous abortions among a group of women who become pregnant compared…
- Trial name
- EAGeR (NCT00467363)
- Testing
- acetylsalicylic-acid (aspirin), Folic acid
- Where
- 4 sites in United States
- Volunteers
- 1,228 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility, Miscarriage Threatening
The Constitution and Efficacy of Chinese Medicine of Infertility Male, Female, and Pregnant Female
The project aims to conduct a retrospective study to assess the impact of Traditional Chinese Medicine (TCM) on improving pregnancy rates and preventing miscarriages.
- Trial name
- NCT06393426
- Testing
- Chinese Herb
- Where
- Taiwan
- Volunteers
- 37,611 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Uterine Evacuation
The Impact of Doulas in Early Pregnancy Management
The purpose of the study is to examine the impact of doula support for women undergoing a manual vacuum aspiration (MVA) for an early pregnancy failure or undesired pregnancy.
- Trial name
- NCT02165540
- Testing
- Doula
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Spontaneous Abortion, Fetal Death
Environmental Factors and Embryonic Development Project
The Environmental Factors and Embryonic Development Project was set up to investigate environmental exposures and behavioral factors responsible for embryonic dysplasia and gestational complications in pregnant women.
- Conditions
- Spontaneous Abortion, Fetal Death, Stillbirth, Birth Defects
- Trial name
- EFED (NCT04182503)
- Testing
- No intervention
- Where
- 19 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Ovarian Reserve, Miscarriage, Recurrent
The Effect of the Ovarian Reserve on the Recurrent Pregnancy Loss
The purpose of this study is to determine whether ovarian reserve is related to recurrent pregnancy loss
- Trial name
- NCT03009370
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
IVF, Embryo Loss
The Use of High Concentration Hyaluronic Acid (HA) Transfer Medium in Repeated Implantation Failure (RIF) Patients
This is a pilot study with the aim to investigate the beneficial effect of bicarbonate buffered medium containing hyaluronan and recombinant human albumin (EmbryoGlue®, Vitrolife) in patients with documented repeated implantation…
- Conditions
- IVF, Embryo Loss, Miscarriage, Recurrent
- Trial name
- RIFLE (NCT04709796)
- Testing
- EmbryoGlue®, Vitrolife, Conventional Transfer
- Where
- Belgium
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Abortion, Spontaneous
Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk
This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han.
- Trial name
- NCT02633475
- Testing
- IL-10 polymorphism
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fourth Affiliated Hospital of Guangxi Medical University
Threatened Abortion
Oral Progesterone for Prevention of Miscarriage in Threatened Abortion
This study evaluates the effectiveness of oral dydrogesterone in preventing miscarriage in threatened abortion. Half of participants will receive oral dydrogesterone, while the other half will receive oral placebo.
- Trial name
- NCT04788108
- Testing
- Dydrogesterone
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Abortion, Habitual, Nutritional Status
Nutritional Deficiencies About Recurrent Miscarriage
The study plans to recruit patients with recurrent miscarriage and detect their niacin, thiamine, vitamin A, vitamin B6, vitamin B12, vitamin D levels in plasma, evaluating if some lack exists.
- Trial name
- NCT04064931
- Testing
- Detection of niacin and other vitamins in plasma
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Circulating Cell Free Fetal DNA, Intrauterine Fetal Demise
The Use of Cell Free Fetal DNA in the Maternal Blood in the Evaluation of Intrauterine Fetal Demise and Miscarriage
Women presenting to Washington Hospital Center with fetal loss would be offered participation in the study. The objective is to determine if ccffDNA obtained from maternal blood is present in the setting of missed abortion or…
- Conditions
- Circulating Cell Free Fetal DNA, Intrauterine Fetal Demise, Miscarriage
- Trial name
- NCT01916928
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Missed Abortion, Medical; Abortion, Fetus
Gemeprost Versus Dinoprostone in First Trimester Miscarriages
Comparison between gemeprost and dinoprostone to evacuate first trimester miscarriages.
- Conditions
- Missed Abortion, Medical; Abortion, Fetus, Incomplete Abortion
- Trial name
- NCT05342467
- Testing
- Gemeprost 1 Mg Vaginal Pessary, Dinoprostone 3 mg
- Where
- 2 sites in Malaysia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia