Clinical trials: Mitochondrial Disorders
Infertility
Mitochondrial Activity of Cumulus Cells From the Cumulus-oocyte Complex and Oocyte Competence
The need for non-invasive biomarkers of oocyte competency has become urgent as women increasingly delay attempts at childbearing.
- Trial name
- NCT02793752
- Testing
- Age
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Mitochondrial Myopathies, Healthy Controls
Diagnostic Screening Tests and Potential Biomarkers in Mitochondrial Myopathies
The purpose of this study is to develop simple diagnostic screeningtests and investigate potential biomarkers for identifying patients with abnormalities of mitochondrial function, which also can be used as outcome measures in…
- Trial name
- NCT03513835
- Testing
- Diagnostic screenings tests
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Insulin Resistance
Free Fatty Acid Induced Insulin Resistance
This study aims to explore time-dependent effects of lipid infusion an intramyocellular lipid metabolites and the induction of impaired insulin signaling.
- Trial name
- FFAIR (NCT01229059)
- Testing
- Lipovenös lipid infusion
- Where
- Germany
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Aging, Sarcopenia
Assessing the Impact of Age, and a Short-term High-intensity Interval Training (HIIT) on Skeletal Muscle Mass and Mitochondrial Activity
The goal of this interventional study is to learn about the role of mitochondrial function in healthy aging, and then go on and assess the role of a home-based exercise program on the changes seen.
- Trial name
- Mi-HIIT (NCT05934760)
- Testing
- High intensity interval training (HIIT), Resistance based training (RET)
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sporadic Dystonia, Dystonia, Familial
Imaging Neuromelanin and Iron in Dystonia/Parkinsonism
To generate pilot data to investigate the potential to use in vivo iron- and neuromelanin-quantification as imaging tools for the diagnostic evaluation of movement disorders with predominant dystonia / parkinsonism.
- Conditions
- Sporadic Dystonia, Dystonia, Familial, Parkinson Disease, Juvenile, Neurodegeneration With Brain Iron Accumulation 5
- Trial name
- NCT03572114
- Testing
- 3Tesla MRI, Burke-Fahn-Marsden Dystonia Rating scale, MDS-United Parkinsons Disease Rating Scale, Part III
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University College, London
Diabetes Mellitus, Type 2
Rice Intervention in Chronic Health Study
The goal of this clinical trial is to learn if the low glycemic index (GI), polyphenol-rich red pigmented rice (UKMRC9) works to improve cardio-metabolic parameters in Malaysian adults with type 2 diabetes (T2D) and healthy…
- Trial name
- RICH (NCT06560541)
- Testing
- UKMRC9, White rice
- Where
- 10 sites in Malaysia
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Taylor's University
Diabetes, Obese
Mitochondrial Dysfunction in Diabetes
The purpose of this study is to determine whether insulin resistance is accompanied by "exercise resistance". Investigators will use mass spectrometry and proteomics analysis to test the hypothesis is that a bout of exercise that…
- Trial name
- PGC-1 (NCT01724502)
- Testing
- Exercise and muscle biopsies
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mitochondrial Respiratory Chain Deficiencies
Abdominal Adiposity and Muscle Mitochondrial Functions
Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance.
- Trial name
- Mithycal (NCT00446745)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Barth Syndrome
Heart and Muscle Metabolism in Barth Syndrome
Barth syndrome (BTHS) is an X-linked disorder caused by abnormal cardiolipin metabolism and is characterized by skeletal and cardiomyopathy and high mortality rates.
- Trial name
- NCT01625663
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Duke University
Optic Atrophy, Autosomal Dominant
Advanced Characterization of Autosomal Dominant Optic Atrophy
The purpose of this study is to determine the anatomy of the retina and the optic nerve in patients with autosomal dominant optic atrophy (ADOA).
- Trial name
- NCT01522638
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Nephropathy, Hypoxia
Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes
Background: Inhibiting the sodium-glucose cotransporter-2 (SGLT2) has been observed to reduce risk of cardiovascular events and kidney failure in type 2 diabetes.
- Conditions
- Nephropathy, Hypoxia, Mitochondrial Alteration, Type 1 Diabetes
- Trial name
- Astronaut (NCT04193566)
- Testing
- Forxiga
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Breast Neoplasms
Using Hyperpolarized [1-13C]Pyruvate to Detect Cardiotoxicity
The anthracycline doxorubicin, first introduced in the 1960's, continues to be an effectively utilized antineoplastic drug. Even at relatively low cumulative doses there is risk of cardiotoxicity.
- Trial name
- HPCardiotox (NCT03685175)
- Testing
- Formal study using hyperpolarized 13C-pyruvate injection, Feasible study using hyperpolarized 13C-pyruvate injection
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Obesity
Nicotinamide Riboside and Mitochondrial Metabolism
Vitamin B3 has recently been found to be a potent modifier of energy metabolism, especially the function of mitochondria. Mitochondria power up all cells in our bodies, by generating fuel, ATP, for cellular functions.
- Trial name
- VitaPower (NCT03951285)
- Testing
- NR in BMI-discordant twins, NR in BMI-concordant twins
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Cocaine Use Disorder, Healthy Controls Group - Age and Sex-matched
Imaging Mitochondrial Complex-I in Cocaine Use Disorder: a [F-18]BCPP-EF PET Study
Studies proposed in this application will image mitochondrial Complex-I in cocaine use disorder (CUD) and matched healthy controls
- Trial name
- NCT07773649
- Testing
- [F-18]BCPP-EF
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Depression, Bipolar Disorder
Mitochondrial Dysfunction, Inflammation, and White Matter Integrity in Youth With Mood Disorders
This study consists of three separate appointments including a clinical assessment (interview and questionnaires), a blood draw, a social stress test, and a brain MRI.
- Conditions
- Depression, Bipolar Disorder, Bipolar Disorder Not Otherwise Specified, Unspecified Mood Disorder
- Trial name
- NCT02596698
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Bronchiolitis Acute, Wheezing
The Role of Vitamin D and Vitamin D Receptor in Recurrent Wheezing in Children With Bronchiolitis: Immunological Association With T-lymphocyte Mitochondrial Mass
A prospective study will be conducted involving children under 2 years of age hospitalized for bronchiolitis during the period 2025-2026.
- Conditions
- Bronchiolitis Acute, Wheezing, RSV
- Trial name
- NCT07700134
- Testing
- No Intervention: Observational Cohort
- Where
- Greece
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Metabolic Disease, Mitochondrial Diseases
Genetic Diagnosis in Inborn Errors of Metabolism
Inborn Errors of metabolism comprise a large number of rare conditions with a collective incidence of around 1/2000 newborns. Many disorders are treatable provided that a correct diagnosis can be established in time, and for many…
- Conditions
- Metabolic Disease, Mitochondrial Diseases, Epilepsy in Children, Epilepsy
- Trial name
- NCT06376279
- Testing
- IEM-EP
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Aging, Frailty
Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial Dysfunction
The goal of this observational study is to evaluate the presence of mitochondrial dysfunction related to oxidative stress and its possible role in frailty, with and without multimorbidity, and to identify possible frailty…
- Conditions
- Aging, Frailty, Mitochondrial Dysfunction, Chronic Disease
- Trial name
- FRAMITO (NCT06433427)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
MELAS Syndrome
L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome
MELAS patients suffer from exercise intolerance, weakness, poor vision or blindness, poor growth, developmental delay, and deafness.
- Trial name
- NCT01603446
- Testing
- L-Arginine
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Racial Disparities, Blood Pressure
The Influence of Mitochondrial-Derived Reactive Oxygen Species on Racial Disparities in Neurovascular Function
Black individuals are at increased cardiovascular disease risk. The central goal of the study is to determine if mitochondrial reactive oxygen species influence blood vessel function and nervous system regulation of blood…
- Conditions
- Racial Disparities, Blood Pressure, Cardiovascular Risk Factor, Renal Function
- Trial name
- MAVHS (NCT04334135)
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Auburn University