Clinical trials: Mitochondrial Function
Cardiometabolic Diseases, Postmenopause
Exercise and Prolonged Fasting to Improve Brown Adipose Tissue Function in Postmenopausal Women
Type of Study: Clinical Trial Goal: The goal of this clinical trial is to investigate mitochondrial function in interscapular brown adipose tissue (iBAT) in postmenopausal women and determine whether aerobic exercise, prolonged…
- Trial name
- EMPOWER-BAT (NCT07837752)
- Testing
- Aerobic exercise, Prolonged fasting
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Hepatic Insufficiency, Hypoalbuminemia
Mitochondrial Function in Patients With Severe Liver Disease
The researchers will recruit patients with liver disease at Parkland Hospital. Patients will fast overnight, and the next morning will receive an oral mixture of [U-13C3]glycerol (25 mg/kg) plus unlabeled glycerol (25 mg/kg).
- Trial name
- SLDglyc (NCT02457702)
- Testing
- Orally administered labeled glycerol
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Aging, Mitochondrial Dysfunction
A Single and Multiple Dose Study of AMAZ-02 to Evaluate Safety and Pharmacokinetics in Elderly Subjects
Part A: The study is a double-blind, randomized, single ascending doses, study in 24 healthy elderly male and female volunteers. Each subject will be randomized for two subsequent doses in three cohorts.
- Conditions
- Aging, Mitochondrial Dysfunction, Muscle Function
- Trial name
- NCT02655393
- Testing
- Mitopure
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Friedreich Ataxia
Evaluation of the Effects of Calcitriol's in the Neurological Symptoms of Friedreich's Ataxia Patients
Friedreich's Ataxia (FA) is an autosomal recessive disease the mutation of which leads to a deficiency of a protein called frataxin, which is responsible for the symptoms of the disease.
- Trial name
- CalcitriolFA (NCT04801303)
- Testing
- Calcitriol, Blood analysis for frataxin's level measurement, Blood analysis for hypercalcemia's control
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Berta Alemany
Mitochondrial Myopathies, Mitochondrial Diseases
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
Past mitochondrial disease treatment studies have been unsuccessful in determining treatment efficacy, and a major factor has been the lack of validated biomarkers in mitochondrial myopathy (MM).
- Trial name
- NCT04086329
- Testing
- Nanosensor
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Dietary Exposure
Effects of L-arginine and L-citrulline Supplementation on Muscle Respiration
The objective of this trial is to determine the effects of dietary supplementation with the amino acids, L-arginine and L-citrulline, on endurance performance and mitochondrial respiration in healthy men compared to…
- Trial name
- NCT03998800
- Testing
- Dietary Supplement, Endurance exercise on a cycle ergometer
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Healthy Adult Participants
Multilevel Exercise Response in Rowers
This observational study aims to evaluate multilevel physiological, molecular, metabolic, intestinal, immunological, and psychophysiological responses to rowing-specific exercise in elite rowers.
- Trial name
- NCT07613619
- Testing
- 2000-m rowing ergometer test, 6000-m rowing ergometer test
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Heart Failure
Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxidative stress in human skeletal muscle, before and after exercise training.
- Trial name
- Calcicard (NCT01014611)
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Brain Aging
Haematococcus Pluvialis Astaxanthin for Brain Aging
We recruit community-dwelling older adults aged 50 and above for a 6-month intervention. Participants are divided into three groups: Placebo Group, Low-Dose Group ( 6 mg/d Haematococcus pluvialis Astaxanthin), High-Dose Group (12…
- Trial name
- NCT07379437
- Testing
- Low-Dose AST, High-Dose AST
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Aging, Endothelial Dysfunction
Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic…
- Conditions
- Aging, Endothelial Dysfunction, Cardiovascular Function, Arterial Stiffness
- Trial name
- NCT05872139
- Testing
- Mitoquinone Mesylate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Ball State University
Type 2 Diabetes, Obesity
The Effect of Roux-en-Y Gastric Bypass on Mitochondrial Function in Type 2 Diabetes
Roux-en-Y gastric bypass (RYGB) surgery induces resolution of type 2 diabetes, often within days after surgery and before significant weight loss.
- Trial name
- NCT01468116
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Iron Deficiency
Effects of Iron Supplementation on Skeletal Muscle Properties in Females With Suboptimal Iron Storage
The goal of this clinical trial is to learn whether oral iron supplementation will increase skeletal muscle iron storage and its effects on exercise capacity in females with suboptimal iron status.
- Trial name
- MyoIRON (NCT07084298)
- Testing
- Oral iron supplement
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Mitochondrial Functions
Phytochemicals on "Metabolic Aging" in Older Overweight Adults
Aging is a complex and inevitable biological process that is associated with numerous chronic health conditions and the development and progression of diseases.
- Trial name
- NCT04919876
- Testing
- fruit/vegetable supplement (FVS)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biofortis, Merieux NutriSciences
Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion
New Non-invasive Modalities for Assessing Retinal Structure and Function
This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other…
- Conditions
- Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion, Hemianopia, Leber Hereditary Optic Neuropathy
- Trial name
- NCT03475173
- Testing
- LSFG-NAVI
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Obesity, Insulin Resistance
Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans
African Americans are at a substantially greater type 2 diabetes risk compared to Caucasians; however, very little data are available on the effects of exercise training on type 2 diabetes risk factors in at risk African…
- Conditions
- Obesity, Insulin Resistance, Sedentary Lifestyle
- Trial name
- HI-PACE (NCT02892331)
- Testing
- Moderate intensity exercise training (MOD-INT), High Intensity exercise training (HI-INT)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Mitochondrial Function, Physical Function
Resveratrol to Enhance Vitality and Vigor in Elders
Resveratrol, a compound found in red wine and dark-skinned grapes, will improve the function of mitochondria (energy producing components) within the leg muscles of moderate functioning older adults.
- Trial name
- REVIVE (NCT02123121)
- Testing
- Resveratrol 1000 mg/day, Resveratrol 1500 mg/day, Vegetable cellulose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Aging, Mitochondrial Function
NAD Supplementation Study
This research project aims to determine whether supplementing with a mixture of the NAD+-precursors NA, NAM, and tryptophan can stimulate skeletal muscle mitochondrial function in physically compromised, elderly humans.
- Trial name
- NADS (NCT03310034)
- Testing
- NAD-precursors, Control
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Healthy Adult Participants, Exercise Training
The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers
The goal of this study is to investigate the effect of combining olive leaf extract supplementation with endurance training (moderate intensity continuous training or sprint interval training).
- Conditions
- Healthy Adult Participants, Exercise Training, Neuromuscular Adaptations, Nutritional Intervention
- Trial name
- OLE_Training_1 (NCT07729072)
- Testing
- Olive leaf extract
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Healthy, Obesity
Mitochondrial Function in Circulating Cells and Muscle Tissue
The main goal of this project is to determine whether mitochondrial function in circulating cells is related to that measured in the muscle fibers of the same subjects.
- Conditions
- Healthy, Obesity, Insulin Sensitivity, Women
- Trial name
- MitoWomen (NCT02700698)
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Ovarian Function at Advanced Reproductive Age
Co Enzyme Q10 Improves IVF Outcome in With Advanced Reproductive Age
The goal of the investigators research is to explore energy production of the ovarian follicle in older reproductive age women at the time of oocyte retrieval.
- Trial name
- NCT01659788
- Testing
- Coenzyme Q10 concomitant treatment
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization