Clinical trials: Mitochondrial Function
Cognition, Multiomics
Probiotic Research: Open-label Functional Intervention and Longitudinal Evaluation in Healthy Adults
This study is a pre-post, open-label cohort study designed to investigate how a food-grade probiotic supplement affects biological measurements and wellbeing in healthy adults.
- Conditions
- Cognition, Multiomics, Microbiome Analysis, Metabolome
- Trial name
- PROFILE (NCT07457242)
- Testing
- Probiotic Supplementation (Lactobacillus plantarum)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- OneCarbon
Diabetes
Relation of White Blood Cell Function to Diabetes
Background: Patients who are pre-diabetic or have adult onset (type 2) diabetes have a significantly greater risk of developing heart, blood vessel, or kidney diseases.
- Trial name
- NCT00570154
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
MItochondrial Myopathies, Mitochondrial Disease
Validation of Nanosensor Oxygen Measurement
Past mitochondrial disease treatment studies have been unsuccessful in determining treatment efficacy, and a major factor has been the lack of validated biomarkers in mitochondrial myopathy (MM).
- Trial name
- NCT06819683
- Testing
- Nanosensor
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Healthy
Dietary Polyphenols and Insulin Sensitivity in Overweight and Obese Humans
In this double-blind, randomized, placebo-controlled study, we aim to investigate the effects of a long-term supplementation on insulin sensitivity, mitochondrial function and substrate metabolism in healthy overweight men and…
- Trial name
- NCT02381145
- Testing
- EGCG+RSV-supplementation
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Volunteers
Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study
The purpose of this study is to define the safety and the biochemical-physiological response of prolonged exposure to a normobaric low-oxygen environment in healthy volunteers.
- Trial name
- MGH-nitrogen (NCT02860975)
- Testing
- Inhaled Nitrogen
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Exercise Performance, Gut -Microbiota
Ergogenic Properties of Magnesium Supplementation
The purpose of the proposed project is to determine if short-term dietary supplementation of magnesium will improve performance during a series of lab-based exercise tests, will favorably modify the gut-microbiota, and will…
- Conditions
- Exercise Performance, Gut -Microbiota, Mitochondrial Function
- Trial name
- NCT05282693
- Testing
- ReMag
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Christopher Bell
Cardiovascular Diseases, Hypertension
Mitochondria Oxidative Stress and Vascular Health Study
Cardiovascular diseases (CVDs) are the number one cause of death in America and most of the post-industrial world. Hypertension is a leading risk factor for CVDs including stroke, myocardial infarction, and heart failure.
- Conditions
- Cardiovascular Diseases, Hypertension, Racism, Vascular Diseases
- Trial name
- MOVHS (NCT05561556)
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Auburn University
Autosomal Dominant Polycystic Kidney Disease
Assessment of Longitudinal Changes in Endothelial Function and Oxidative Stress in Normotensive Patients With ADPKD
The purpose of this study is to determine whether patients with autosomal dominant polycystic kidney disease (ADPKD) present with abnormal endothelial function, increased levels of NOX4 activity and mitochondrial abnormalities…
- Trial name
- NCT03493802
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy Volunteers
Effects of Raltegravir (Isentress®) on Lipid and Carbohydrate Metabolism and Mitochondrial Function in Healthy Volunteers
Raltegravir is the first of a new antiretroviral class. A better profile of metabolic toxicity is expected. In order to better define its effects, without interference with other drugs, a study on healthy volunteers is warranted.
- Trial name
- RALMET-VOLHCB (NCT00772720)
- Testing
- raltegravir
- Where
- Spain
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Human Volunteers
Effects of Micro-dose and Low-dose Recombinant Human Erythropoietin on Mitochondrial Function and Cognitive Performance
A recent study by Plenge et al. revealed that rhEpo treatment enhances skeletal muscle mitochondrial respiratory capacity in humans indicating a muscle ergogenic effect of rhEpo on aerobic metabolism.
- Trial name
- NCT03093506
- Testing
- Low-dose rhEpo, Micro-dose rhEpo
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Mitochondrial Diseases
Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity
The purpose of this study is to test how different doses of a statin, Lipitor, affect muscle health and function, and cardiovascular fitness.
- Trial name
- NCT03351998
- Testing
- Lipitor 20Mg Tablet, Lipitor 80Mg Tablet
- Where
- 2 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
HIV Infections
Metabolic Effects of Enfuvirtide in Healthy Volunteers
The metabolic effects of T-20 are not completely known, since the drug is used in combination with other antiretroviral agents. A short-term study in healthy volunteers, with a double-blind crossover design vs.
- Trial name
- NCT00657761
- Testing
- Enfuvirtide
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona