Clinical trials: Mitral Valve Regurgitation
Acute Ischemic Stroke
Safety Study of PP-007 in Subjects With Acute Ischemic Stroke
The HEMERA-1 Extension (Part III) is a prospective, open-label, multicenter study to evaluate safety of two doses of PP-007 in Acute Ischemic Stroke (AIS) subjects receiving Intravenous Thrombolysis (IVT) or mechanical…
- Trial name
- HEMERA-1 (NCT04677777)
- Testing
- PP-007 (Two doses administered 24±6 hours apart) + SOC (IVT or MT or IVT+MT)
- Where
- 8 sites in United States
- Volunteers
- 24 people
- Sponsor
- Prolong Pharmaceuticals
Malignant Central Nervous System Neoplasm, Metastatic Malignant Neoplasm in the Central Nervous System
Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Detecting Lactate and Bicarbonate in Participants With Central Nervous System Tumors
This early phase I trial studies how well hyperpolarized carbon C 13 pyruvate magnetic resonance imaging works in detecting lactate and bicarbonate in participants with central nervous system tumors.
- Trial name
- NCT03565367
- Testing
- Gadolinium, Hyperpolarized Carbon C 13 Pyruvate, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Daniel M. Spielman
Intra Cerebral Hemorrhage, Hypertension
Proper Timing of Control of Hypertension and Outcome in Acute Spontaneous Intracerebral Hemorrhage.
The ideal management of blood pressure in BP after acute intracerebral haemorrhage is still debated and whether a higher intensive reduction of blood pressure after acute intracerebral haemorrhage may be better or not is still…
- Trial name
- NCT04167644
- Testing
- Modified Rankin Scale (mRS)
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University Hospital
Valvular Heart Disease Patients, Aortic Stenosis
Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE)
Heart valve disease and weakened heart muscle (left ventricular systolic dysfunction) are common in older adults and often go undetected until serious complications such as heart failure develop.
- Conditions
- Valvular Heart Disease Patients, Aortic Stenosis, Mitral Regurgitation, Left Ventricular Diastolic Dysfunction
- Trial name
- IMPROVE (NCT07756398)
- Testing
- Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.)
- Where
- 2 sites in United States
- Volunteers
- 1,088 people
- Sponsor
- University of Texas Southwestern Medical Center
Barlow's Disease, Prolapse; Mitral
Minimally Invasive or Conventional Edge-To-Edge Repair for Severe Mitral Regurgitation Due to Bileaflet Prolapse in Barlow's Disease: Does the Surgical Approach Have an Impact on the Long-term Results?
The study evaluates the long-term results of patients affected by bileaflet prolapse in Barlow's Disease, treated with edge-to-edge technique between 1997 and 2011.
- Trial name
- NCT04002648
- Testing
- Right minithoracotomy, Sternotomy
- Volunteers
- 208 people
- Sponsor
- Ospedale San Raffaele
Mitral Regurgitation
STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication for Oral Anticoagulant
Mitral regurgitation (MR) is the most common valvular heart disease, affecting approximately 24.2 million people worldwide (with a higher prevalence in older age groups).
- Trial name
- STAR-TEER Ⅱ (NCT07007143)
- Testing
- Experimental: Aspirin monotherapy, Active Comparator: Aspirin+Clopidogrel
- Where
- China
- Volunteers
- 1,032 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Mitral Regurgitation
Cephea Early Feasibility Study
The objective of this study is to evaluate the preliminary safety and effectiveness of the Cephea Mitral Valve System for the treatment of symptomatic patients with mitral valve disease (including mitral regurgitation, mitral…
- Trial name
- NCT05061004
- Testing
- Cephea Mitral Valve System
- Where
- 22 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- Abbott Medical Devices
Aortic Valve Stenosis, Mitral Regurgitation
Phono- and Electrocardiogram Assisted Detection of Valvular Disease
The diagnosis of valvular heart disease (VHD), or its absence, invariably requires cardiac imaging. A familiar and inexpensive tool to assist in the diagnosis or exclusion of significant VHD could both expedite access to…
- Conditions
- Aortic Valve Stenosis, Mitral Regurgitation, Heart Murmurs, Valvular Heart Disease
- Trial name
- PEA-Valve (NCT03458806)
- Testing
- AS Algorithm 1, AS Algorithm 2, MR Algorithm 1
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Breast Neoplasms
Choline Quantification in Breast Cancer by MRS
Choline has been found in increased concentration in breast cancer patients. Hypothesis: The choline signal as observed by MRS is sensitive to treatment, and a positive response to treatment will give a reduction in choline…
- Trial name
- NCT00201487
- Sponsor
- Norwegian University of Science and Technology
Cardiovascular Diseases
Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation
The objective of this trial is to compare the safety, the efficacy and the cost-effectiveness of 2 therapeutic strategies (optimal standard of care therapy alone versus percutaneous MitraClip procedure and optimal standard of…
- Trial name
- MITRA-FR (NCT01920698)
- Testing
- Percutaneous MitraClip Device Implantation, control
- Where
- 40 sites in France
- Volunteers
- 304 people
- Sponsor
- Hospices Civils de Lyon
Mitral Valve Insufficiency, Mitral Valve Prolapse
European FIH Study - NeoChord Transcatheter Mitral Repair System for Symptomatic Mitral Regurgitation
Safety and performance evaluation of the NeoChord Transcatheter Mitral Repair System in patients with degenerative mitral valve regurgitation.
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Prolapse, Degenerative, Mitral Regurgitation
- Trial name
- NCT05425628
- Testing
- NeoChord Transcatheter Mitral Repair System (or "NeoChord System")
- Volunteers
- 30 people
- Sponsor
- NeoChord
Breast Cancer
Evaluation of Patients With Breast Cancer Using DCE-MRI, MRS, and Proteomics
RATIONALE: Diagnostic procedures, such as dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI), magnetic resonance spectroscopy (MRS), and tissue proteomics, may help doctors find and diagnose breast cancer and plan the…
- Trial name
- NCT00656604
- Testing
- proteomic profiling, lumpectomy or mastectomy, dynamic contrast-enhanced magnetic resonance imaging
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Circadian Rhythm
Effect of Circadian Rhythm on Brain NAD Measured by Phosphorus Magnetic Resonance Spectroscopy at 7 Tesla
The Discovery of the circadian clock first established a genetic basis for behavior, and our understanding of circadian rhythm (CIR) has since expanded to provide molecular insights into physiology and disease.
- Trial name
- ChronoBrain (NCT05093088)
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Aortic Valve Regurgitation, Mitral Valve Regurgitation
Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation
Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse…
- Conditions
- Aortic Valve Regurgitation, Mitral Valve Regurgitation, Left Ventricle Dilated, Left Atrium Dilated
- Trial name
- ORMIX (NCT06805253)
- Testing
- Not applicable - observational study
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Atherosclerosis
Study to Investigate the Sensitivity and Specificity of 3.0 Tesla MRI for Carotid Artery Plaque
The aim of this study is to develop non-invasive MRI, and MRS approaches that will quantify the plaque composition and lipid content of plaques and will have the potential for repeated in vivo measurements.
- Trial name
- NCT01632254
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mitral Regurgitation, Atrial Fibrillation
Gene Expression Profiles in Patients With Permanent Atrial Fibrillation (AF) Versus Sinus Rhythm (SR)
The aim of this project is to determine the morphological criteria of apoptosis in atrial tissues of patients with AF versus SR at transcriptome and genomic size.
- Conditions
- Mitral Regurgitation, Atrial Fibrillation, Sinus Rhythm
- Trial name
- NCT00970034
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara University
Fibromyalgia
The Effect of Autoreactive Autoantibodies on Peripheral and Central Disease Mechanisms in Fibromyalgia.
This observational study aims to compare disease burden and pain characteristics between fibromyalgia patients with high levels of autoreactive autoantibodies, fibromyalgia patients with low levels of autoreactive autoantibodies…
- Trial name
- FINE (NCT07346950)
- Where
- Sweden
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Mitral Valve Surgery
Comparative Study Between Conventional Crystalloid Cardioplegic Solution With Modified Del Nido Cardioplegia
Mitral valvuloplasty for correction of chronic mitral regurgitation carries a lower operative mortality and morbidity and improved long-term survival than does mitral valve replacement.
- Trial name
- NCT05797090
- Testing
- Crystalloid Cardioplegic solution
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- mohamed
Functional Mitral Regurgitation
Treatment of Moderate FMR During AVR
Debates exist on the treatment of moderate functional mitral regurgitation (FMR) in patients undergoing aortic valve replacement (AVR) for aortic valve disease.
- Trial name
- NCT05566340
- Testing
- mitral valve repair
- Volunteers
- 154 people
- Sponsor
- Fuwai Yunnan Cardiovascular Hospital
Mitral Regurgitation
Haemodynamics of Mitral Regurgitation Reduction
There is uncertainty in terms of the superiority of conventional valve surgery or percutaneous transcatheter intervention for the treatment of severe mitral regurgitation (MR) in high risk patients.
- Trial name
- STRESS-MR (NCT05403840)
- Testing
- Mitral valve surgery, Transcatheter mitral valve intervention
- Volunteers
- 60 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust