Clinical trials: Mixed Dementias
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Dementia, Mixed, Dementia of Alzheimer Type
REACH Hope Intervention for Dementia and TBI Caregivers
This three-year randomized clinical trial will evaluate a behavioral intervention for caregivers of Veterans with traumatic brain injury (TBI) and Alzheimer's dementia or mixed Dementia (AD/MD) to reduce caregiver depression…
- Conditions
- Dementia, Mixed, Dementia of Alzheimer Type, TBI (Traumatic Brain Injury)
- Trial name
- REACH Hope (NCT04969796)
- Testing
- REACH Hope
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Memphis VA Medical Center
Dementia, Dementia, Vascular
Virtual Individual Cognitive Stimulation Therapy: a Proof of Concept Study
Due to COVID-19, the routine treatment for dementia, Cognitive Stimulation Therapy (CST), is currently suspended in multiple countries. Access to treatment is, therefore, paramount.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- V-iCST (NCT04828434)
- Testing
- Virtual Individual Cognitive Simulation Therapy
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Alzheimer Disease, Alzheimer Dementia
Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study
The purpose of the study is to evaluate the use of autologous Bone Marrow Derived Stem Cells (BMSC) as a means to improve cognitive impairment as occurs in Alzheimer's Disease and other dementias and to improve behavior and…
- Conditions
- Alzheimer Disease, Alzheimer Dementia, Vascular Dementia, Lewy Body Disease
- Trial name
- ACIST (NCT03724136)
- Testing
- Intravenous Bone Marrow Stem Cell (BMSC) Fraction, Intranasal Topical Bone Marrow Stem Cell (BMSC) Fraction, Near Infrared Light
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 100 people
- Sponsor
- MD Stem Cells
Depressive Syndrome
Study of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer's Disease, Vascular Dementia, and Mixed Vascular and Alzheimer's Dementia
The goal of the present study is to compare the effectiveness of the active (S)-enantiomer of citalopram, escitalopram with placebo in the treatment of patients with depressive syndrome complicating Alzheimer's dementia (AD)…
- Trial name
- NCT00229333
- Testing
- Escitalopram
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Dementia
Constructing and Evaluating the Effectiveness of a Community-based Older Adults Dementia Prevention Education Program
This study adopted a mixed-methods approach and was conducted in two exploratory phases. The first phase focused on development and involved three focus group interviews with community-dwelling older adults.
- Trial name
- NCT06998836
- Testing
- Dementia prevention education, General Health Education Leaflet
- Where
- Taiwan
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Chang Gung University of Science and Technology
Dementia
Music Therapy in Methodist Homes: a Study Investigating the Impact of a Music Therapy Programme
The study is a cluster randomised control trial, which aims to investigate the effectiveness of music therapy in minimising Behavioural and Psychological Symptoms of Dementia (BPSD) in older adults with dementia.
- Trial name
- NCT01744600
- Testing
- Music Therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 27 people
- Sponsor
- Methodist Homes for the Aged
Trauma Injury, Intensive Care Neurological Disorder
Experiences and Attitudes Towards Agitated Behaviours in TBI ICU Patients: a Protocol for an Interprofessional Mixed-method Study
EXSTATIC is a multicenter mixed methods convergent study exploring experiences and attitudes of ICU healthcare professionals caring of agitated traumatic brain injury (TBI) patients.
- Trial name
- EXSTATIC (NCT04741399)
- Volunteers
- 98 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Care Transition, Communication
Care Transition Patient Experience Study With Electronic Tool
Patients being admitted to hospital are becoming more complex and they often require a team of health professionals (doctors from different disciplines, nurses, and allied health professionals) working together to meet their…
- Trial name
- NCT03970174
- Testing
- Care Connector care transition module
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Trillium Health Partners
Dementia, Mixed, Dementia Mild
An Innovative Supportive Care Model for Dementia and Traumatic Brain Injury
There are an increasing number of people in the U.S. with Alzheimer's disease and other dementias. Traumatic brain injuries (TBIs) are also common among both civilians and military personnel, and TBIs increase a person's risk for…
- Conditions
- Dementia, Mixed, Dementia Mild, Dementia Moderate, Traumatic Brain Injury
- Trial name
- NCT04495686
- Testing
- Telehealth-delivered Care Coordination Program
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- University of Virginia
Dementia Caregiver
The Existential Cognitive Intervention to Enhance Positive Aspect of Caregiving (EXCITE-PAC) in a Dementia Context
Research evidence is emerging on the co-existence of a positive caregiving experience in the physically and psychosocially taxing dementia care context, but little attention has been paid to promoting the positive aspects of…
- Trial name
- EXCITE-PAC (NCT07396298)
- Testing
- Existential-cognitive intervention to enhance PAC, Usual care
- Where
- Hong Kong
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dementia
Education Program for Care Home Staff
The competence of care home staff in dementia care is highly influential to the quality of care that adversely affects both people living with dementia and staff and in Mainland China where knowledge on dementia among care home…
- Trial name
- NCT04445077
- Testing
- Dementia Competence Education for care home setting, Printed educational materials
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Dementia; Degenerative, Dementia Mixed
Longitudinal Study to Investigate Different Transcranial Electrical Stimulation
This research investigates the effect of different frequencies of tACS (0 Hz, 30 Hz, 50 Hz, 70 Hz, 90 Hz) and tRNS with cognitive exercises in a regimen protocol of 4 weeks, everyday (Monday to Friday).
- Trial name
- tES (NCT06877312)
- Testing
- Transcranial Direct Current Stimulation (tDCS), 30 Hz Transcranial Alternating Current Stimulation (tACS), 50 Hz Transcranial Alternating Current Stimulation (tACS)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Dementia, Mild Cognitive Impairment
SAMi Intervention Study to Evaluate Smartwatch Interventions in Persons With MCI and Dementia
Assistive Technologies (ATs) can help people living with dementia (PwD) maintain their everyday activity. Still, there is a gap between potential and supply. Involving future users can close the gap.
- Conditions
- Dementia, Mild Cognitive Impairment, Alzheimer Disease, Dementia With Lewy Bodies
- Trial name
- SAIN_UMR (NCT05885620)
- Testing
- drinking reminder and cognitive task (smartwatch-based application)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Rostock
Dementia
Study to Evaluate the Effect of Megestrol Acetate in Weight Loss in Dementia Patients
The purpose of this study is to demonstrate the efficacy of megestrol acetate in the gain of body weight in patients with primary or mixed Dementia with a weight loss.
- Trial name
- NCT00503516
- Testing
- Megestrol acetate
- Where
- Spain
- Volunteers
- 39 people
- Sponsor
- Rottapharm Spain
Alzheimer Disease, Functional Food
Non-pharmacological Intervention for Preclinical Alzheimer's Disease
Alzheimer's disease (AD) is the most common form of neurodegenerative disorders leading to dementia. Currently, there has been no effective drugs targeting this disease.
- Conditions
- Alzheimer Disease, Functional Food, Subjective Cognitive Decline, Intervention
- Trial name
- NCT04279418
- Testing
- Mixed functional foods supplementation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- XuanwuH 2
Dementia
Effects of a Robot on Physical and Psychosocial Outcomes of Persons With Dementia and Their Social Environment at Home
Background: Dementia rates are increasing worldwide and consequently burden global healthcare resources to a serious degree. However, there is a declining number of caregivers to provide care.
- Trial name
- NCT03818217
- Testing
- Coach Pepper group, Tablet group
- Where
- Austria
- Volunteers
- 64 people
- Sponsor
- Medical University of Graz
Workplace Violence, Health Professionals
Chatbot to Support Healthcare Professionals Experiencing Workplace Aggression
This study aims to design, develop, and validate a chatbot (SANIDAD SEGURA) intended to support healthcare professionals who experience workplace aggression.
- Conditions
- Workplace Violence, Health Professionals, Chatbot, Digital Health
- Trial name
- Sanidad-Segura (NCT07473531)
- Testing
- Chatbot SANIDAD SEGURA
- Where
- Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Distrito Sanitario Almeria
Alzheimer Disease
Meaningful Aspects of Health for Adults With Dementia, Their Care Partners and Healthcare Practitioners
The aim of this study is to describe, using a non-interventional survey, the relevant aspects of health in adults with ADRD for the patients themselves, their carers and healthcare professionals.
- Trial name
- DiME (NCT06242574)
- Testing
- Survey
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Alzheimer's Disease, Mild Cognitive Impairment
Performance of AclarusDx™, a Blood-Based Transcriptomic Test for AD, in US Patients Newly Referred to a Memory Center
The purpose of this study is to assess the performance of AclarusDx™, an investigational blood test detecting gene expression information, and intended to help physicians in making an Alzheimer's Disease diagnosis in patients…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Vascular Dementia, Fronto-temporal Dementia
- Trial name
- NCT01465360
- Where
- 3 sites in United States
- Volunteers
- 160 people
- Sponsor
- Exonhit