Clinical trials: Moderate Depression
Depression, Anxiety
Mediterranean-style Dietary Pattern (MDP), Mood and Anxiety
Observational studies and a limited numbers of RCTs have observed that habitual Mediterranean-style dietary pattern (MDP) consumption is associated with improved mental health and cognition.
- Trial name
- MediMood (NCT05927376)
- Testing
- Mediterranean diet, Western diet
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Depression and/or Anxiety in the Mild-to-moderate Range, Stress (Psychology)
SanaMente: A Peer-Led Program to Reduce Health Disparities in Rural Latino/a Communities
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effectiveness of the SanaMente peer-led mental health and lifestyle program for rural Latino/a adults with chronic medical conditions…
- Conditions
- Depression and/or Anxiety in the Mild-to-moderate Range, Stress (Psychology), Chronic Medical Illness
- Trial name
- SanaMente (NCT07705776)
- Testing
- SanaMente
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Major Depressive Disorder, Major Depressive Episode
MRS and Medication Response: A Pilot Study
We hope to demonstrate that magnetic resonance spectroscopy can detect brain concentration levels of paroxetine (Paxil) or citalopram (Celexa) or escitalopram (Lexapro) in depressed patients.
- Conditions
- Major Depressive Disorder, Major Depressive Episode, Major Depressive Disorder, Recurrent, Major Depression Mild
- Trial name
- NCT03254342
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Stanford University
Respiratory Depression, Blood Pressure
Cardiopulmonary Responses to Exposure to Ozone and Diesel Exhaust
The US EPA Clean Air Multiyear research program is moving toward a multi-pollutant approach to the assessment of air pollution in response to recommendations by the NRC 2004 and the BOSC in 2005.
- Trial name
- DEPOZ (NCT01874834)
- Testing
- ozone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Depressive Symptoms Mild to Moderate in Severity
Therapeutic Touch and Acupressure on Depressive Symptoms
Therapeutic touch intervention Participants in the therapeutic touch group received eight sessions over four weeks (two sessions per week), with each session lasting approximately 20 minutes.
- Trial name
- Postmenopausal (NCT07532512)
- Testing
- Therapeutic touch intervention, Acupressure intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Osmaniye Korkut Ata University
Hepatic Impairment
Pharmacokinetics of AGO178 in Participants With Liver Impairment
AGO178 was developed for the treatment of depression. A new formulation is being tested in the present study: a tablet to be placed and dissolved under the tongue (sublingual tablet).
- Trial name
- NCT01531309
- Testing
- AGO178
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Healthy, Depression Symptoms
Effects of a Single-bout of Moderate-intensity Aerobic Exercise on Mood and Mental Health Biomarkers in Adults with Depressive And/or Anxiety Symptoms
This study investigates whether a single session of aerobic exercise (like running) can improve the participants' mood and whether such benefits can be explained by changes in the blood factors (like hormones) and brain activity.
- Conditions
- Healthy, Depression Symptoms, Anxiety Symptoms
- Trial name
- NCT06736067
- Testing
- Exercise
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- YAU Suk Yu Sonata
Depressive Symptoms
Physical Exercise and Depressive Symptoms in Moderately or Severely Depressed Adults
This study is a comparative trial comparing the time course of depressive symptoms between moderately and severely depressed participants over a 10-week long exercise program
- Trial name
- EXIMOS (NCT05703776)
- Testing
- Nordic Walking
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Je Bouge Pour Mon Moral
Depression
Efficacy of Rice Bran Extract in Mildly to Moderately Depressed Adults
The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects and tolerability of rice bran extract on depressive symptoms and related biomarkers in mildly to moderately depressed…
- Trial name
- NCT05180136
- Testing
- Rice bran extract group, Control group
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Depression, Anxiety
Mitigating Mental Health Issues Among Women's Sport Student-Athletes Through a Moderate-Intensity Exercise Intervention
The goal of this clinical trial is to learn about moderate-intensity indoor cycling interventions in women's sport student-athletes transitioning into college and collegiate sport.
- Conditions
- Depression, Anxiety, Stress, Psychological
- Trial name
- NCT06182150
- Testing
- Moderate-Intensity Indoor Cycling Exercise
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Moderate Depressive Episode, Mild Depressive Episode
Online Mindfulness-Based Cognitive Therapy in Depressed Sample
The goal of this clinical trial is to evaluate the effectiveness of the online 6-weeks Mindfulness-Based Cognitive Therapy (iMBCT) in depressed sample and compare the guided intervention to an unguided one.
- Trial name
- iMBCT (NCT05919875)
- Testing
- Unguided Mindfulness-Based Cognitive Therapy, Guided Mindfulness-Based Cognitive Therapy
- Where
- Poland
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Warsaw
All Cause Mortality, Cardiovascular Diseases
Advice of Moderate Drinking Pattern Versus Advice on Abstention on Major Disease and Mortality
The goal of this clinical trial is to test two advices on alcohol drinking in more than 10.000 Spanish adult drinkers (men of 50 or more years and women of 55 or more years).
- Conditions
- All Cause Mortality, Cardiovascular Diseases, Invasive Cancer, Liver Cirrhosis
- Trial name
- UNATI (NCT06338215)
- Testing
- Moderate Alcohol Drinking Pattern, Abstention
- Where
- Spain
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
PostPartum Depression
Curio Digital Therapy for the Treatment of Post-partum Depression
Primary Objective: Evaluate the clinical effectiveness of the MamaLift Plus app compared to control (digital sham plus treatment as usual) for the management of PPD in the observed population for a period of 9 calendar weeks.
- Trial name
- SuMMER (NCT05958095)
- Testing
- MamaLift Plus
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Healthcare Innovation Technology Lab
Low Mood
Effect of a Nutritional Supplement on Mental Wellness in Adults
Trillions of microbes reside in human gut and constitute "gut microbiota". Composition of these microbes and substances produced by them play an important role in human health and wellness.
- Trial name
- NCT06058364
- Testing
- Intervention 1 - Triglyceride
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Pharmavite LLC
Mild to Moderate Depressive Symptoms
Online Self-healing Program
Background. Almost two thirds of adolescents experience a mental disorder before the age of 25. Among mental disorders, depression is one of the most common among young people aged between 15 to 24, with a prevalence of 13.5% to…
- Trial name
- iCBT-A (NCT07374653)
- Testing
- Online Cognitive Behaviural Therapy, Online Relaxation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- City University of Hong Kong
Major Depressive Disorder, Bipolar Affective Disorder, Currently Depressed, Moderate
The Role of Negr1 In Modulating Neuroplasticity in Major Depression (RONIN)
Patients belonging to Group 1 (Major Depression) and 2 (Bipolar Disorder) will be tested with psychometric and functional scales at baseline (T0) and after 4 weeks of pharmacological therapy (T1), to evaluate clinical and…
- Trial name
- RONIN (NCT06131268)
- Testing
- Venlafaxine
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Depression Mild, Depression Moderate
Long-term Effects ReSet Your Mind - Mechanisms
See: ClinicalTrials.gov ID: NCT05402150 Relevant for this Paper: This investigation aims to evaluate the stability of the effectiveness of different two-week online interventions in a four months follow-up regarding reward…
- Trial name
- NCT06072209
- Testing
- Behavioral Activation, Mindfulness and Gratitude, Combination of Behavioral Activation and Mindfulness and Gratitude
- Where
- Germany
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Depression, Depression Moderate
Kintsugi Voice Device Pilot Study
A prospective, single arm, non-randomized, pilot clinical validation study to evaluate the ability of the Kintsugi Voice Device (the Device) to aid clinical assessment for depression by comparing its output with a diagnosis made…
- Conditions
- Depression, Depression Moderate, Depression Severe, Depression Mild
- Trial name
- NCT06374056
- Testing
- Kintsugi Voice Device
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Kintsugi Mindful Wellness, Inc.
Mild to Moderate Depression
Pilot Study Using Transcranial Electrostimulation (TESA-HB) Therapy for the Treatment of Depressive Symptoms
This pilot study uses TESA-HB therapy for treatment of depressive symptoms associated with mild and moderate depression episodes.
- Trial name
- TESAHBPilot (NCT03471754)
- Testing
- TESA-HB Transcranial Electronic Stimulation Device
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Annecto LLC
Depression, Depression Moderate
Kintsugi Voice Device Pivotal Study
A prospective, single arm, non-randomized, pivotal clinical validation study to evaluate the ability of the Kintsugi Voice Device (the Device) to aid clinical assessment for depression by comparing its output with a diagnosis…
- Conditions
- Depression, Depression Moderate, Depression Severe, Depression Mild
- Trial name
- NCT06809907
- Testing
- Kintsugi Voice Device
- Where
- United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Kintsugi Mindful Wellness, Inc.