Clinical trials: Moderate Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Anosognosia Evaluation After Cranocerebral Trauma Moderate to Severe
This study is conducted over 18 months. The main objective of this study is to test and compare the relevance and reliability of different tools for measuring the anosognosia.
- Trial name
- ANOSOGNOSIA (NCT02333006)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Traumatic Brain Injury, Concussion, Intermediate
Intervention to Change Affect Recognition and Empathy
Determine the feasibility, practicality, and early efficacy of a TeleRehab program (ICARE) to improve outcomes for persons with traumatic brain injury (TBI) in recognizing and responding to others' emotions alongside their care…
- Conditions
- Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes
- Trial name
- ICARE (NCT05636020)
- Testing
- ICARE Treatment
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Indiana University
Traumatic Brain Injury
The Effect of Single Dose D-Cycloserine on Cognitive Outcome in Moderate Traumatic Brain Injury (TBI) Patients
In this study of patients with moderate traumatic brain injury with frontal brain contusions patients will be randomized to treatment with a single dose of either D-cycloserine or placebo given 48-72 hours after injury.
- Trial name
- DCS (NCT01343862)
- Testing
- D-cycloserine
- Where
- 3 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Traumatic Brain Injury
Long Term Effects of Erythropoietin in Patients With Moderate to Severe Traumatic Brain Injury
Traumatic brain injury is catastrophic event that commonly require treatment in an intensive care unit. Management is mainly supportive aiming at avoiding hypoxia, hypotension, hypoglycaemia and increased intracerebral pressure.
- Trial name
- NCT03061565
- Testing
- erythropoietin
- Where
- Australia
- Volunteers
- 356 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Vestibular Disorder, Headache
The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild to Moderate Traumatic Brain Injury
Test the hypothesis that a certain set of osteopathic manipulation procedures preformed on patients with mild to moderate traumatic brain injury will result in accelerated rates of recovery assessed using vestibular function…
- Conditions
- Vestibular Disorder, Headache, Traumatic Brain Injury
- Trial name
- NCT03163901
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Traumatic Brain Injury, Pain
Characterization & Treatment of Chronic Pain After Moderate to Severe TBI
This is a five year multi-site, cross sectional, observational study designed to examine chronic pain and pain treatment after moderate to severe TBI.
- Trial name
- NCT03739307
- Where
- 13 sites in United States
- Volunteers
- 3,805 people
- Sponsor
- Craig Hospital
SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm
Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital
Context : Moderate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for…
- Conditions
- SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm, Moderate Traumatic Brain Injury, Severe Traumatic Brain Injury
- Trial name
- VASO-TC (NCT06560372)
- Testing
- Additional realization of a brain perfusion scan sequence which would allow the radiological diagnosis of CV
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital Center of Martinique
Moderate Traumatic Brain Injury
Intracranial Pressure Monitoring in Moderate Traumatic Brain Injury
Objectives The primary focus for scientific investigation is to conduct a multi-center observational study to determine if intracranial pressure (ICP) monitoring to direct treatment of patients with moderate traumatic brain…
- Trial name
- IPMMTBI (NCT04900168)
- Testing
- Intracranial pressure monitoring
- Where
- China
- Volunteers
- 832 people
- Sponsor
- Tang-Du Hospital
Traumatic Brain Injury
Prediction of Secondary Neurological Deterioration in Patients With Moderate Traumatic Brain Injury
Patients with moderate traumatic brain injury (mTBI) are 1,5 times more frequent than those with severe TBI and some of them will develop secondary neurologic deterioration (SND) within the first 7 days.
- Trial name
- PREDICT-TCM (NCT04854954)
- Where
- France
- Volunteers
- 142 people
- Sponsor
- University Hospital, Brest
Cerebral Palsy, Traumatic Brain Injury
Effect of Trunk Support on Academic Engagement of Children With Severe Disability
This study evaluates the effect of optimizing trunk support based on segmental principles of trunk control, on academic engagement of children in academic settings.
- Conditions
- Cerebral Palsy, Traumatic Brain Injury, Metabolic Disease, Hypotonia
- Trial name
- NCT05391594
- Testing
- customized posture support
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Hartford
Craniocerebral Trauma, Hypothalamic-pituitary Disorders
Long-term Follow-up of Pituitary and Hypothalamic Dysfunction in Children Who Have Suffered Moderate to Severe Head Trauma Included in the ENDOC TC Cohort
The annual incidence of traumatic brain injury (TBI), all causes combined, varies between 180 and 300 per 100,000. TBI increases the risk of death or serious sequelae by a factor of 8.
- Conditions
- Craniocerebral Trauma, Hypothalamic-pituitary Disorders, Pediatric, Endocrinology
- Trial name
- ENDOC TC 2 (NCT07533435)
- Testing
- Telephone questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury
Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
The primary objective of the study is to determine whether armodafinil treatment is more effective than placebo treatment in patients with excessive sleepiness associated with mild or moderate closed traumatic brain injury (TBI).
- Trial name
- NCT00893789
- Testing
- Armodafinil
- Where
- 73 sites in United States, Germany and 2 more
- Volunteers
- 117 people
- Sponsor
- Cephalon, Inc.
Traumatic Brain Injury
Methylprednisolone for Moderate to Severe Traumatic Brain Injury
The goal of this clinical trial is to learn if standard-dose methylprednisolone sodium succinate can improve neurological recovery and safety in adults with moderate to severe traumatic brain injury (TBI).
- Trial name
- ESM-TBI (NCT07180277)
- Testing
- Methylprednisolone (MP)
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Zhangjiagang First People's Hospital
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI)
Memantine as an Additive Therapy in Patients With Traumatic Brain Injury
Memantine has shown promise in mitigating secondary brain injury in previous studies. One study demonstrated that early memantine administration in moderate TBI patients resulted in lower serum neuron-specific enolase levels and…
- Trial name
- NCT06914310
- Testing
- Memantine, Mannitol
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Traumatic Brain Injury, Chronic Balance Disorder
Study of Safety and Effectiveness of PoNS Device to Treat Chronic Balance Deficit Due to Traumatic Brain Injury (TBI)
The purpose of this study is to determine if clinic and home training with a study device will improve a balance deficit. The study device is called Portable Neuromodulation Stimulator (PoNS).
- Trial name
- NCT02429167
- Testing
- Cranial nerve non-invasive neuromodulation via PoNS device
- Where
- 3 sites in United States, Canada
- Volunteers
- 122 people
- Sponsor
- Helius Medical Inc
Moderate to Severe Traumatic Brain Injury
Ante-hypophyseal Dysfunctions in Children Following Moderate to Severe Traumatic Brain Injuries
Annual incidence of severe traumatic brain injuries (TBI) varies from 180 to 300 out of 100.000. Mortality or severe sequelae risk is increased 8 fold after a TBI.
- Trial name
- Endoc-TC (NCT01250132)
- Testing
- Biological and behavioral explorations
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Hospices Civils de Lyon
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder
Ketamine Treatment for PTSD and MDD in TBI
The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
- Trial name
- NCT06228391
- Testing
- IV ketamine, Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Trauma, Brain
Transcranial Doppler in Mild and Moderate Traumatic Brain Injury (TBI)
Utility of transcranial Doppler as an Early Predictor of Neurological deterioration in Mild and Moderate Traumatic Brain Injury
- Trial name
- NCT05151978
- Testing
- Transcranial Doppler
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
Brain Injuries, Traumatic
Validation of the Scandinavian Guidelines for Minor and Moderate Head Trauma in Children
Head injuries are common among children and adolescents, with many of them assessed in emergency departments each year. Most children recover fast, with full resolution of symptoms as headache, dizziness or fatigue.
- Trial name
- SHIPP (NCT05964764)
- Where
- 16 sites in Norway, Sweden
- Volunteers
- 5,300 people
- Sponsor
- Halmstad County Hospital
Traumatic Brain Injury, Mild Traumatic Brain Injury
Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND)
The goal of this pilot clinical trial is to learn whether memantine can be given safely and successfully to adults in hospital with a mild or moderate traumatic brain injury (TBI).
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI), TBI
- Trial name
- MEND (NCT07867210)
- Testing
- Memantine
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Nova Scotia Health Authority