Clinical trials: Moderate to Severe Traumatic Brain Injury
Trauma, Brain
PRECISION-TBI - An Observational Study of Patients With Moderate to Severe Traumatic Brain Injury
Traumatic Brain Injury (TBI) is a devastating condition and a leading cause of long-term disability. Every patient with TBI has a different type of injury and is treated differently from hospital to hospital making it very…
- Trial name
- NCT05855252
- Testing
- No intervention
- Where
- 9 sites in Australia
- Volunteers
- 300 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Traumatic Brain Injury, Epilepsy
Preventing Epilepsy After Traumatic Brain Injury With Topiramate
Our hypothesis is that topiramate will reduce acute seizures after traumatic brain injury and will help prevent the development of epilepsy after traumatic brain injury.
- Trial name
- PEPTO (NCT00598923)
- Testing
- topiramate, phenytoin
- Volunteers
- 6 people
- Sponsor
- University of Pennsylvania
Traumatic Brain Injury, Cerebral Edema
Safety and Efficacy of ABX-101 in Participants Aged 18 to 50 Years of Age With Moderate to Severe Traumatic Brain Injury
The purpose of this study is to investigate the clinical improvement measured by the Glasgow Outcome Scale Extended (GOS-E) with ABX-101 compared with Placebo intramuscular injection in participants with moderate to severe TBI.
- Trial name
- NCT06096415
- Testing
- ABX-101 1mg, ABX-101 2mg
- Volunteers
- 45 people
- Sponsor
- Abalonex, LLC
Traumatic Brain Injury, Pain
Characterization & Treatment of Chronic Pain After Moderate to Severe TBI
This is a five year multi-site, cross sectional, observational study designed to examine chronic pain and pain treatment after moderate to severe TBI.
- Trial name
- NCT03739307
- Where
- 13 sites in United States
- Volunteers
- 3,805 people
- Sponsor
- Craig Hospital
Moderate to Severe Traumatic Brain Injury
Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients
Traumatic brain injury (TBI) is a major cause of death and severe prolonged disability. Intracranial hypertension (ICH) is a critical risk factor of bad outcomes after TBI.
- Trial name
- COBI (NCT03143751)
- Testing
- NaCl20% (Continuous hyperosmolar therapy)
- Where
- 10 sites in France
- Volunteers
- 370 people
- Sponsor
- Nantes University Hospital
Cerebral Palsy, Traumatic Brain Injury
Effect of Trunk Support on Academic Engagement of Children With Severe Disability
This study evaluates the effect of optimizing trunk support based on segmental principles of trunk control, on academic engagement of children in academic settings.
- Conditions
- Cerebral Palsy, Traumatic Brain Injury, Metabolic Disease, Hypotonia
- Trial name
- NCT05391594
- Testing
- customized posture support
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Hartford
Moderate-to-Severe Traumatic Brain Injury
Comparing Sedatives for Intracranial Pressure Control in Traumatic Brain Injury
The goal of this clinical trial is to compare the effects of propofol, midazolam, and dexmedetomidine on intracranial pressure control and clinical outcomes in adults with moderate-to-severe traumatic brain injury undergoing…
- Trial name
- ICP-TBI (NCT07678216)
- Testing
- propofol, midazolam, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Aswan University
Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury
Valproic AcId for Traumatic BRAin INjury Trial
The long-term goal of the clinical trial is to develop effective, safe, and easily administered life-saving treatments for patients with moderate to severe traumatic brain injury (TBI).
- Trial name
- VIBRANT (NCT07166393)
- Testing
- Valproic Acid (VPA), Standard of care treatment + normal saline
- Where
- 8 sites in United States
- Volunteers
- 432 people
- Sponsor
- Northwestern University
Major Depressive Disorder, Traumatic Brain Injury
Adapted Cognitive Behavioral Treatment for Depression in Patients With Moderate to Severe Traumatic Brain Injury
Cognitive behavioral therapy for major depressive disorder (MDD) was adapted for individuals with moderate to severe traumatic brain injury (TBI) (CBT-TBI). A structured, treatment manual was developed.
- Trial name
- NCT03307070
- Testing
- Cognitive Behavioral Therapy for individuals with TBI, Waitlist Control
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury
Blood NfL and Functional Outcomes After Moderate-to-Severe TBI
Prospective cohort study of 150 adults with moderate-to-severe TBI. Blood NfL is measured at admission, day 1, and day 3 to examine its relationship, alone and with CT imaging, to 3-month functional outcome (GOSE).
- Trial name
- NCT07901712
- Testing
- neurofilament light chain ECLIA
- Volunteers
- 175 people
- Sponsor
- Rutgers, The State University of New Jersey
Euthyroid Sick Syndromes in Traumatic Brain Injury Patient and GFAP Level
Euthyroid Sick Syndrome (ESS) Effect on Traumatic Brain Injury Patients and Its Relation With GFAP Level
Euthyroid sick syndrome (ESS) effects on patients suffering from traumatic brain injury (TBI) have received little attention. Moreover, there is limited evidence that serum levels of thyroid-related hormones might influence…
- Trial name
- ESS (NCT04806672)
- Volunteers
- 50 people
- Sponsor
- Minia University
Traumatic Brain Injury
Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury
In the exploratory multi-center Phase 2 a study safety, tolerability, pharmacodynamics and pharmacokinetics of the Nitric Oxide Synthase inhibitor VAS203 is assessed in patients with moderate and severe traumatic brain injury.
- Trial name
- NOSTRA (NCT02012582)
- Testing
- VAS203, Saline
- Where
- 6 sites in Austria, France and 3 more
- Volunteers
- 32 people
- Sponsor
- veriNOS operations GmbH
Moderate to Severe Traumatic Brain Injury
Cognitive Rehabilitation of Working Memory After Moderate to Severe Traumatic Brain Injury
The study aims to demonstrate improvement of daily life functioning and improvement of cognitive tests in post traumatic brain injury (TBI) patients suffering from working memory deficit, by a 3-month specific cognitive…
- Trial name
- REHAB-MDT (NCT03874416)
- Testing
- Specific rehabilitation, Non-specific rehabilitation
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Moderate to Severe Traumatic Brain Injury
Ante-hypophyseal Dysfunctions in Children Following Moderate to Severe Traumatic Brain Injuries
Annual incidence of severe traumatic brain injuries (TBI) varies from 180 to 300 out of 100.000. Mortality or severe sequelae risk is increased 8 fold after a TBI.
- Trial name
- Endoc-TC (NCT01250132)
- Testing
- Biological and behavioral explorations
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury
Early Propranolol After Traumatic Brain Injury: Phase II
The primary objective of this study is to determine in patients with traumatic brain injury (TBI) the safe dosing of propranolol.
- Trial name
- EPAT: Phase II (NCT01202110)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm
Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital
Context : Moderate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for…
- Conditions
- SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm, Moderate Traumatic Brain Injury, Severe Traumatic Brain Injury
- Trial name
- VASO-TC (NCT06560372)
- Testing
- Additional realization of a brain perfusion scan sequence which would allow the radiological diagnosis of CV
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital Center of Martinique
Coma, Traumatic
Dopaminergic Disruption Induced by Traumatic Coma: Dopaminergic Pathways Abnormalities and Biomarkers of Recovery Using MRI and 18F-LBT-999 PET
The neural correlates of consciousness have been studied at the macroscopic level. However, the neurochemical basis of these processes remains poorly understood.
- Trial name
- ComaDopa (NCT06930261)
- Testing
- LBT-999
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Traumatic Brain Injury
Comparison Between the IMPACT's Score and the Clinician's Perception to Predict the Prognosis of Severe and Moderate Traumatic Brain Injury
Main objective : To compare the quality of the prognostic assessment, (adverse evolution at 6 months) of severe and moderate traumatic brain injury, performed by the clinician compared to the prognosis described by the IMPACT…
- Trial name
- PREDICT-TBI (NCT03874546)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 83 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy, Traumatic Brain Injury
Targeted Training for Trunk Control_case Series Cerebral Palsy
If a child with cerebral palsy does not develop independent sitting balance by 4 years of age, their prognosis for walking is very poor.
- Trial name
- CP_TT (NCT02097836)
- Testing
- Targeted Training
- Volunteers
- 11 people
- Sponsor
- University of Oregon
Traumatic Brain Injury
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
The purpose of this study is to look at the relationship between growth hormones, and recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with the body's ability to produce growth hormones.
- Trial name
- NCT00929045
- Testing
- Growth Hormone Replacement
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Virginia