Clinical trials: Moderate to Severe Traumatic Brain Injury, active
Traumatic Brain Injury (TBI)
Prognostic Model for Predicting Outcome After Moderate to Severe Paediatric Traumatic Brain Injury
Due to ethical and logistical challenges related to paediatric research, there is limited age-appropriate evidence for managing paediatric traumatic brain injury (pTBI).
- Trial name
- PROMPT (NCT07538440)
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm
Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital
Context : Moderate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for…
- Conditions
- SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm, Moderate Traumatic Brain Injury, Severe Traumatic Brain Injury
- Trial name
- VASO-TC (NCT06560372)
- Testing
- Additional realization of a brain perfusion scan sequence which would allow the radiological diagnosis of CV
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital Center of Martinique
Traumatic Brain Injury
Emotional Awareness Therapy Study
The purpose of this study is to learn about the potential benefits of two different training programs in helping improve emotional health and well-being in people who have had a traumatic brain injury.
- Trial name
- TREAT (NCT07624825)
- Testing
- TREAT-A, TREAT-B
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Hackensack Meridian Health
Traumatic Brain Injury
Blood NfL and Functional Outcomes After Moderate-to-Severe TBI
Prospective cohort study of 150 adults with moderate-to-severe TBI. Blood NfL is measured at admission, day 1, and day 3 to examine its relationship, alone and with CT imaging, to 3-month functional outcome (GOSE).
- Trial name
- NCT07901712
- Testing
- neurofilament light chain ECLIA
- Volunteers
- 175 people
- Sponsor
- Rutgers, The State University of New Jersey
Acute Brain Injuries, Moderate to Severe Traumatic Brain Injury
Effects of Recombinant Human Growth Hormone in Elderly Patients With Moderate to Severe Acute Brain Injury (GH-ABI-RCT)
This study is a multicenter, randomized controlled trial aimed at evaluating the effectiveness and safety of recombinant human growth hormone (rhGH) in elderly patients who have suffered moderate to severe acute brain injuries…
- Trial name
- GH-ABI-RCT (NCT07481656)
- Testing
- Recombinant Human Growth Hormone (rhGH) Injection, Standard Care (Treatment as Usual)
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Anhui Provincial Hospital
Traumatic Brain Injury, Concussion, Intermediate
Intervention to Change Affect Recognition and Empathy
Determine the feasibility, practicality, and early efficacy of a TeleRehab program (ICARE) to improve outcomes for persons with traumatic brain injury (TBI) in recognizing and responding to others' emotions alongside their care…
- Conditions
- Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes
- Trial name
- ICARE (NCT05636020)
- Testing
- ICARE Treatment
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Indiana University
Moderate to Severe Traumatic Brain Injury
FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial
The goal of this clinical trial is to learn about treatment with fresh frozen plasma (FFP) in individuals with moderate to severe traumatic brain injury.
- Trial name
- NCT06062888
- Testing
- Fresh Frozen Plasma (FFP)
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Northwestern University
Moderate-to-Severe Traumatic Brain Injury
Comparing Sedatives for Intracranial Pressure Control in Traumatic Brain Injury
The goal of this clinical trial is to compare the effects of propofol, midazolam, and dexmedetomidine on intracranial pressure control and clinical outcomes in adults with moderate-to-severe traumatic brain injury undergoing…
- Trial name
- ICP-TBI (NCT07678216)
- Testing
- propofol, midazolam, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Aswan University
Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury
Valproic AcId for Traumatic BRAin INjury Trial
The long-term goal of the clinical trial is to develop effective, safe, and easily administered life-saving treatments for patients with moderate to severe traumatic brain injury (TBI).
- Trial name
- VIBRANT (NCT07166393)
- Testing
- Valproic Acid (VPA), Standard of care treatment + normal saline
- Where
- 9 sites in United States
- Volunteers
- 432 people
- Sponsor
- Northwestern University
Trauma, Brain
Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries
After injury, survivors of msTBI depend on informal family caregivers. Upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive…
- Trial name
- CG-Well (NCT05307640)
- Testing
- CG-Well, Information Support & Referral (ISR)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Natalie Kreitzer
Traumatic Brain Injury
Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury
The goal of this clinical trial is to test the safety of the drug Angiotensin (1-7) and learn whether it works well as a treatment in people who have suffered a moderate to severe traumatic brain injury (TBI).
- Trial name
- ANGel T (NCT06282965)
- Testing
- Angiotensin (1-7), Sterile saline
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona
Chronic Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Cognitive Network Restoration Therapy for Moderate to Severe Traumatic Brain Injury: A Feasibility Study
The purpose of this feasibility clinical investigation is to evaluate the safety and usability of central thalamic deep brain stimulation (CT-DBS) for use in patients with chronic moderate to severe traumatic brain injury (TBI)…
- Trial name
- NCT07730099
- Testing
- Deep brain stimulation
- Volunteers
- 40 people
- Sponsor
- ReEmerge, Inc.
Traumatic Brain Injury
GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI
The goal of this clinical trial is to evaluate GetUp\&Go, a program for promoting increased physical activity in individuals at least 6 months post moderate-to-severe traumatic brain injury.
- Trial name
- NCT06028334
- Testing
- GetUp&Go, GetUp&Go with 10-Week Delay
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Albert Einstein Healthcare Network
Traumatic Brain Injury
Methylprednisolone for Moderate to Severe Traumatic Brain Injury
The goal of this clinical trial is to learn if standard-dose methylprednisolone sodium succinate can improve neurological recovery and safety in adults with moderate to severe traumatic brain injury (TBI).
- Trial name
- ESM-TBI (NCT07180277)
- Testing
- Methylprednisolone (MP)
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Zhangjiagang First People's Hospital
Coma, Traumatic
Dopaminergic Disruption Induced by Traumatic Coma: Dopaminergic Pathways Abnormalities and Biomarkers of Recovery Using MRI and 18F-LBT-999 PET
The neural correlates of consciousness have been studied at the macroscopic level. However, the neurochemical basis of these processes remains poorly understood.
- Trial name
- ComaDopa (NCT06930261)
- Testing
- LBT-999
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Craniocerebral Trauma, Hypothalamic-pituitary Disorders
Long-term Follow-up of Pituitary and Hypothalamic Dysfunction in Children Who Have Suffered Moderate to Severe Head Trauma Included in the ENDOC TC Cohort
The annual incidence of traumatic brain injury (TBI), all causes combined, varies between 180 and 300 per 100,000. TBI increases the risk of death or serious sequelae by a factor of 8.
- Conditions
- Craniocerebral Trauma, Hypothalamic-pituitary Disorders, Pediatric, Endocrinology
- Trial name
- ENDOC TC 2 (NCT07533435)
- Testing
- Telephone questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury
Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury
New learning and memory impairment (NLMI) is a common and devastating manifestation of TBI associated with substantial life burdens. Persons with moderate to severe TBI have shown improvement in NLM for prose material (e.g.
- Trial name
- CRUSH-IT (NCT05716048)
- Testing
- KF-mSMT Plus Aerobic Exercise Training, KF-mSMT Plus Stretching Exercise Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kessler Foundation