Clinical trials: Modification
Fat Burn
Changes in Abdominal Tissues Induced by Magnetic Device - MRI Evaluation
The study is a prospective multi-center open-label single-arm study. The subjects will be enrolled and assigned into a single study group.
- Trial name
- NCT03545633
- Testing
- Treatment with High Intensity Focused ElectroMagnetic system.
- Where
- 2 sites in United States, Bulgaria
- Volunteers
- healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Osteo Arthritis Knee
Foot Wear Modification Along With Physical Therapy in Knee Osteoarthritis
Orthotics and Prosthetics are important areas where physiotherapists order a variety of assistive aids to restore, compensate, or prevent physical ailments and disorders, such as here, Knee Osteoarthritis.
- Trial name
- NCT04536519
- Testing
- osteoarthritis management
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Isra University
Dysphagia, Stroke
Changes in Sensitivity, Taste and Smell in Stroke Patients
This study evaluates changes in swallowing using endoscopic swallowing studies and measuring of pharyngeal sensitivity, taste and smell in stroke patients.
- Trial name
- 5S (NCT03240965)
- Testing
- FEES (flexible endoscopic evaluation of swallowing), Sensitivity threshold, Taste-/smell-test
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Anxiety Disorders
Attention Bias Modification Treatment (ABMT) for Anxiety Disorders in Youth
Attention biases in threat processing have been assigned a prominent role in the etiology and maintenance of anxiety disorders. Attention Bias Modification Treatment (ABMT) utilizes computer-based protocols to implicitly modify…
- Trial name
- NCT02460536
- Testing
- Attention Bias Modification treatment (ABMT), Exposure only +ABMT, Attention training only +ABMT
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel Aviv University
PTEN-Altered Advanced Solid Tumors and HER2 Negative Breast Cancer
Leflunomide in Patients With PTEN-Altered Advanced Solid Malignancies and HER2 Negative Breast Cancer
Leflunomide in patients with PTEN-Altered advanced solid tumors or HER2 negative breast cancer. Phase 1A objectives are to determine the safety, tolerability, and the MTD of leflunomide in patients with PTEN-Altered advanced…
- Trial name
- NCT04997993
- Testing
- Leflunomide
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Deborah Doroshow
Overweight, Obesity
Gender- and Culturally-Sensitive Weight Loss Intervention for Hispanic Males
The investigators propose to 1) assess the feasibility, acceptability and preliminary efficacy of a gender- and culturally-sensitive weight loss intervention in 48 overweight/obese Hispanic males ages 18-64 over 12 weeks; 2)…
- Trial name
- NCT02783521
- Testing
- Counseling sessions, Wait List Control
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Hodgkin Lymphoma, Adult, Hodgkin Disease Recurrent
Phase 2 Study Evaluating Autologous CD30.CAR-T Cells in Patients With Relapsed/Refractory Hodgkin Lymphoma (CHARIOT)
This is a two-part, Phase 2, multicenter, open-label, single arm study to evaluate the safety and efficacy of autologous CD30.CAR-T in adult and pediatric subjects with relapsed or refractory CD30+ classical Hodgkin Lymphoma.
- Conditions
- Hodgkin Lymphoma, Adult, Hodgkin Disease Recurrent, Hodgkin Disease Refractory, Hodgkin Disease, Pediatric
- Trial name
- NCT04268706
- Testing
- CD30.CAR-T, Fludarabine, Bendamustine
- Where
- 5 sites in United States
- Volunteers
- 97 people
- Sponsor
- Tessa Therapeutics
Advanced or Recurrent Solid Tumor Harboring an NTRK Gene Fusion
NTRK Gene Fusion - Positive Advanced or Recurrent Solid Tumors, a Rare Cancer Caused by Specific Changes in the Genes
Researchers want to learn more about the use of larotrectinib as a real-world treatment for tropomyosin receptor kinase fusion cancer, also called TRK fusion cancer.
- Trial name
- NCT04945330
- Testing
- Larotrectinib (Vitrakvi, BAY2757556)
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Bayer
Movement, Abnormal, Lower Extremity Problem
Hip Activation and FSDT
The purpose of this study is to determine if activation training of the hip musculature affects muscle activation and frontal plane mechanics in healthy individuals.
- Trial name
- NCT05642065
- Testing
- Hip muscle activation home exercise program
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Weight Loss
Effect of Moderate Weight Loss in Metabolically Abnormal Lean Subjects
Obesity is associated with a constellation of cardiometabolic abnormalities (including insulin resistance, elevated blood pressure and dyslipidemia) that are risk factors for diabetes and cardiovascular disease.
- Trial name
- MAL (NCT02452567)
- Testing
- Moderate (8-10%) diet-induced weight loss
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Advanced Glioma
CAR T Cells in Treating Patients With Malignant Gliomas Overexpressing EGFR
The purpose of this study is to determine whether autologous T cells bearing chimeric antigen receptor that can specifically recognize EGFR overexpressed in tumor cells is safe and effective for patients with EGFR-overexpressing…
- Trial name
- NCT02331693
- Testing
- anti-EGFR CAR T
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Traumatic Brain Injury
Effects of TT301 on Cytokine Levels Post Endotoxin Challenge
This study will evaluate the effects of TT301 on cytokine levels in healthy male volunteers participating in an endotoxin challenge.
- Trial name
- NCT01357421
- Testing
- TT301
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- OPKO Health, Inc.
Dietary Modification, Kidney Diseases, Chronic
Metabolomics for Identifying Biomarkers of Dietary Intake and Kidney Disease Progression
The present record represents a secondary data analysis of the Modification of Diet in Renal Disease (MDRD) Study. For this analysis, the MDRD study data and specimens were retrieved from the National Institute of Diabetes and…
- Trial name
- MDRD (NCT03202914)
- Testing
- Usual protein and phosphorus diet, Low protein and phosphorus diet, Very low protein and phosphorus
- Where
- United States
- Volunteers
- 840 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Acute Malnutrition, Severe, Malnutrition, Child
Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia
The R-SWITCH intervention aims to address the low coverage of treatment for severe wasting (SAM) by leveraging existing community groups to deliver an integrated package focused on prevention, screening, referral, and treatment…
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06380504)
- Testing
- R-SWITCH integrated intervention package
- Where
- Ethiopia
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Macular Degeneration, Age Related
Evaluating Metabolic Changes Induced by PhotoBioModulation Through Spectrally Resolved Autofluorescence in Dry Age-Related Macular Degeneration Patients
The best treatment to prevent the evolution of early and intermediate forms of dAMD to atrophic degeneration is PhotoBioModulation (PBM).
- Trial name
- PBM-dAMD (NCT06582511)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Francesco Bandello
Cataracts
Modified Intraocular Lens to Reduce Eye Inflammation After Cataract Surgery in Uveitis Patients
This study will test the effectiveness of an intraocular lens treated with heparin in reducing or preventing inflammation after cataract surgery in patients with uveitis.
- Trial name
- NCT00001311
- Testing
- heparin-surface modified intraocular lens
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Eye Institute (NEI)
Solid Tumor, Gastric Cancer
A Phase I Trial of CCT303-406 in Patients With Relapsed or Refractory HER2 Positive Solid Tumors
This clinical study is to investigate the safety and tolerability of CCT303-406 CAR modified autologous T cells (CCT303-406) in subjects with relapsed or refractory stage IV metastatic HER2-positive solid tumors.
- Conditions
- Solid Tumor, Gastric Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT04511871
- Testing
- CCT303-406
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai PerHum Therapeutics Co., Ltd.
COVID, Disseminated Intravascular Coagulation
Coagulation Changes Associated With COVID-19 Infection
This study will study the potential utility of the Quantra QPlus System in patients inflicted with COVID-19 disease.
- Conditions
- COVID, Disseminated Intravascular Coagulation, Coagulation Disorder
- Trial name
- NCT04460664
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HemoSonics LLC
Obesity
Randomized Controlled Clinical Trial of Weight Loss Programs in Obese Persons
The purpose of this study is to compare two approaches to a diet and exercise-based weight loss program.
- Trial name
- SHINE (NCT00960414)
- Testing
- SHINE
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Metabolic Syndrome, Overweight or Obesity
Impact of Time-Restricted Eating on Metabolic Homeostasis, Inflammation and Oxidative Stress in Metabolic Syndrome
The main purpose of the clinical trial is to determine the health impact of a dietary intervention known as time-restricted eating (TRE) in patients with metabolic syndrome (defined as the presence of elevated fasting plasma…
- Conditions
- Metabolic Syndrome, Overweight or Obesity, PreDiabetes, Weight Loss
- Trial name
- TREMNIOS (NCT04328233)
- Testing
- Time-Restricted Eating
- Where
- Poland
- Volunteers
- 27 people
- Sponsor
- Nicolaus Copernicus University
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