Clinical trials: Modification
Non Alcoholic Fatty Liver Disease
A Digital Solution for Individuals With Non Alcoholic Fatty Liver Disease
Sidekick Health has developed a digital behavioral change program (SK-241) specifically designed for people with metabolic derangements and non-alcoholic fatty liver disease (NAFLD).
- Trial name
- NCT05426382
- Testing
- A digital care solution for patients with NAFLD
- Where
- 2 sites in Iceland
- Volunteers
- 38 people
- Sponsor
- Sidekick Health
Neuromyelitis Optica Spectrum Disorders (NMOSD)
Modified Zipper Therapy for AQP4-IgG Positive Neuromyelitis Optica Spectrum Disorder
Study Title: A National, Multicenter, Randomized Controlled Trial of the Modified Zipper Therapy in AQP4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder (ELITE Study) Brief Summary: The goal of this clinical trial is to…
- Trial name
- ELITE (NCT07420296)
- Testing
- Eculizumab administration, High-dose corticosteroid pulse therapy, Plasma exchange (PE)
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Tianjin Medical University General Hospital
Breast Cancer Prevention
MELIORA Virtual Coach Intervention for Breast Cancer Prevention
Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide, with early-onset cases increasing due to genetic and lifestyle factors.
- Trial name
- MELIORA (NCT07200427)
- Testing
- MELIORA Virtual Coach Intervention, Control (generic advice)
- Where
- 7 sites in Greece, Lithuania and 2 more
- Volunteers
- 2,080 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Febrile, Neutropenia
Assessment of New Blood Culture Methods on the Microbiological Documentation of Febrile Neutropenia
Febrile neutropenia are microbiologically documented in only 30% of the cases, and almost exclusively by blood cultures. The reasons for this low documentation are likely multiple: (1) some of these fevers are of non-infectious…
- Conditions
- Febrile, Neutropenia, Post-chemotherapy
- Trial name
- HEMATOCPLUS (NCT00913042)
- Testing
- sample blood
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gestational Weight Gain, Obesity
A Weight Maintenance Program Promoting Fat Loss in Pregnancy in Women With Obesity
The aims of this randomized controlled trial are to determine the effects of a lifestyle program that supports weight maintenance and fat mass loss during pregnancy in women with obesity on changes in 1) maternal weight, fat…
- Trial name
- Healthy Mamas (NCT04731688)
- Testing
- Weight Maintenance Group
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Sever's Disease, Achilles Tendinopathy
Heel Pain in Adolescents: A Pilot Study on the Effectiveness of Exercise Therapy and Activity Modification
Invesigators plan to conduct a 12-week longitudinal cohort study of 30 subjects with calcaneal apophysitis. Subjects will be included if they are between 7-17 years-old, have experienced an insidious onset of heel pain with…
- Conditions
- Sever's Disease, Achilles Tendinopathy, Insertional Achilles Tendinopathy, Apophysitis; Calcaneus
- Trial name
- NCT04816188
- Testing
- Exercise Therapy and Activity Modification
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Delaware
Weaning Failure
Changes of Weaning Parameter in Weaning Failure Patient After Tracheostomy as a Predictor of Subsequent Weaning
Weaning from mechanical ventilator is an essential element in the care of critically ill intubated patients receiving mechanical ventilation.
- Trial name
- NCT01312142
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Obesity (Disorder)
Targeting Sedentary Behavior Reduction and Physical Fitness Enhancement in Women Before and Beyond Bariatric Surgery- BARIMOV Study Protocol
Introduction: Sedentary behavior (SB) and insufficient physical activity (PA) interact to worsen physical fitness (PF), obesity-related complications and diseases (ORCD), and all-cause mortality in women with obesity.
- Trial name
- BARIMOV (NCT07663942)
- Testing
- Sedentary behavior reduction program on physical fitness.
- Where
- Portugal
- Volunteers
- 72 people
- Sponsor
- Hospital de Sao Sebastiao
Chronic Kidney Disease, Hypertension
Diuretics and Volume Overload in Early CKD
Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes.
- Trial name
- DOCK (NCT05171686)
- Testing
- Diuretic augmentation (hydrochlorothiazide, chlorthalidone, furosemide, torsemide, or bumetanide)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- VA Office of Research and Development
Bodily Self-Consciousness, Interoception
Hyperventilation Effects on Bodily Self-Consciousness
This study examines how voluntary fast, deep breathing (hyperventilation) affects the way healthy adults perceive their own body.
- Conditions
- Bodily Self-Consciousness, Interoception, Healthy Volunteers
- Trial name
- HYPERSELF (NCT07769710)
- Testing
- Voluntary hyperventilation (guided paced breathing), Normal spontaneous breathing (within-subject control), Synchronous respiratory-visual VR feedback
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Renal Failure, End Stage Renal Disease
Safety and Clinical Performance of a Dialyzer With a Modified Polysulfone Membrane
The clinical investigation will be performed to generate clinical data on clearances and removal rates (for ß2-microglobulin, myoglobin, phosphate, creatinine, and urea) as well as biocompatibility of the modified polysulfone…
- Trial name
- eMPORA (NCT03315624)
- Testing
- Dialyzer
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Neuroinflammation, Autism Spectrum Disorder
Imaging - Clinical Evaluation of Altered Nervous System Drainage
The current study aims to evaluate the aspects of perfusion, fluid diffusivity in the interstitium and the T1 and T2 signal of the PVS and WMH.
- Trial name
- I-CLEANED (NCT06432023)
- Testing
- Magnetic resonance imaging
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Atrial Arrhythmia
Relationship Between the Posterior Atrial Wall and the Esophagus: Esophageal Position and Temperature MEasurement During Atrial Fibrillation Ablation.
A multimodal strategy integrating esophageal visualization with the multidetector computed tomography (MDCT) and simultaneous temperature monitoring has never been put into practice.
- Trial name
- AWESOME-AF (NCT04394923)
- Testing
- Modification of the pulmonary vein ablation line, Regular PVI ablation
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Centro Medico Teknon
Work Related Upper Limb Disorder, Musculoskeletal Pain
Evaluation and Modification of Surgeon Ergonomics in the Operation Room Using Artificial Intelligence Analytics
The study is working to identify actions of surgeons in the operating room that can contribute to work-related musculoskeletal disorders.
- Trial name
- NCT06576570
- Testing
- Education presentation of surgical ergonomics, Summary of Ergonomic Measurement System
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Hypothermia, Hypothermia, Accidental
Evaluation of a Patient Warming Concept Following the German S3 Guideline for Prevention of Intraoperative Hypothermia
The aim of the study is to evaluate a patient prewarming concept following the recommendations of the S3-guideline "Prevention of perioperative hypothermia" with respect to incidence and complications of perioperative…
- Trial name
- NCT02206997
- Where
- Germany
- Volunteers
- 485 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Weight Loss
The Effect of Severe Weight Loss and Protein Intake on Bone
The purpose of this study is to learn whether the amount of dietary protein can influence bone health during the weight loss after weight loss surgery.
- Trial name
- NCT00472680
- Testing
- Caloric restriction, high protein, Caloric restriction; normal protein, Nutrition Education
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rutgers University
Nasopharyngeal Carcinoma, EBV Infection
A Bidirectional Study in Exploring the Dynamic Changes of Plasma and Urine Metabolites of Nasopharyngeal Carcinoma.
The transformation process of nasopharyngeal carcinoma is complex, so it is particularly important to explore the relationship between various disease states on its clinical pathway.
- Trial name
- NCT05682703
- Testing
- Proteomics technology and liquid biopsy
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Movement Disorders, Parkinson Disease
Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
- Conditions
- Movement Disorders, Parkinson Disease, Parkinsonian Disorders, Dystonia
- Trial name
- NCT00355927
- Testing
- Sedation with IV propofol
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Fever, Parents
Online Training to Improve Parents' Fever Management Practices
This study was planned to evaluate the effects of education provided to parents via WhatsApp on fever management. This research is a randomized controlled trial.
- Trial name
- NCT07061327
- Testing
- Online fever management
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Recep Tayyip Erdogan University
PtCO2, Extracorporeal Ventilation
Assessment of the Evolutions of Transcutaneous CO2 With the Modification of Blood Flow During On-pump Cardiac Surgery
There are no available criteria for determining the optimal flow rate and mean arterial pressure level in patients under cardiopulmonary bypass (CPB).
- Trial name
- NCT02362841
- Volunteers
- 41 people
- Sponsor
- European Georges Pompidou Hospital
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