Clinical trials: Modification
Nasopharyngeal Cancinoma (NPC)
Prophylactic Nanocrystalline Megestrol Acetate Versus Placebo for Chemoradiotherapy-Related Anorexia in Nasopharyngeal Carcinoma
This phase III randomized, double-blind, placebo-controlled trial evaluates whether nanocrystalline megestrol acetate can reduce anorexia in patients with locally advanced nasopharyngeal carcinoma (NPC) undergoing concurrent…
- Trial name
- NCT07796789
- Testing
- Nanocrystalline Megestrol Acetate Oral Suspension
- Where
- 3 sites in China
- Volunteers
- 204 people
- Sponsor
- Sun Yat-sen University
Skin Laxity
Clinical Assessment of Skin Tightening and Contour Change of Submental Tissue Using Bipolar Radiofrequency Microneedling
The purpose of this study is to evaluate the safety and efficacy of bipolar fractional radiofrequency treatment via use of the Profound System to achieve skin tightening and contour change in lax submental (beneath the chin)…
- Trial name
- NCT04477187
- Testing
- Dermal Handpiece
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Child, Only
Effect of Pillates on Children With Backpack Syndrome
This randomized clinical trial focuses on a sample of 139 of children diagnosed with backpack syndrome, assessing both subjective pain levels and objective measures of trunk muscle endurance before and after a structured Pilates…
- Trial name
- NCT07248514
- Testing
- Pilates exercise, General Stretching exercises
- Where
- Pakistan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Climate Change, Child Health
Assessing Sustainable Behaviors and Health Impacts of Climate Change
The relationship between climate change, sustainability and child health is complex and important. These three concepts are interacting factors and have significant impacts on children's health.
- Trial name
- NCT06290804
- Testing
- education
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
The Effect of Listening to Music During CPAP on the Agitation Levels and Compliance.
Aim: This study was conducted to determine the effect of listening to music during CPAP on the agitation levels of intensive care patients who underwent CPAP due to COVID-19 and their compliance with the treatment.
- Trial name
- NCT05102084
- Testing
- Listening to music with a bluetooth headset to patients receiving CPAP support
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- SÜMEYYE BİLGİLİ
Age Related Macular Degeneration (AMD), Age Related Macular Degeneration
Evaluating the Relationship Between Function and Structure Using Data From a GA Natural History Cohort
Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration that leads to progressive and irreversible vision loss.
- Conditions
- Age Related Macular Degeneration (AMD), Age Related Macular Degeneration, AMD, Geographic Atrophy
- Trial name
- ARCHERY (NCT07424235)
- Volunteers
- 60 people
- Sponsor
- IRCCS Ospedale San Raffaele
Cerebral Palsy
Constraint-induced Movement Therapy and Self-regulation for Children With Cerebral Palsy
This study examines the effect of combining modified constraint-induced movement therapy (mCIMT) and self-regulation (SR) in promoting upper limb function of children with hemiplegic cerebral palsy (CP) studying in a school-based…
- Trial name
- NCT02957708
- Testing
- mCIMT + SR, Control
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- University of Western Sydney
Diabetic Macular Edema
OCT-Based Screening for Early Retinal Changes in Asymptomatic Diabetic Patients
The goal of this observational study is to detect early retinal changes in people with diabetes who do not have visual symptoms.
- Trial name
- DREAM-OCT (NCT07232225)
- Testing
- Spectral Domain OCT Imaging
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Assiut University
Traumatic Brain Injury
Emotional Processing Intervention for Children With TBI
Investigating an emotional processing program, that is modified for use with children, is effective for children with a traumatic brain injury (TBI).
- Trial name
- NCT04826068
- Testing
- Emotional Processing
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Neuroendocrine Tumors
Lutathera and ASTX727 in Neuroendocrine Tumours
Patients entered into the study will receive ASTX727 orally for 5 days, prior to receiving Lutathera treatment on Day 8, to determine whether pre-treatment with ASTX727 results in re-expression of somatostatin receptor-2 in…
- Trial name
- LANTana (NCT05178693)
- Testing
- ASTX727, Lutathera
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- Imperial College London
Non-alcoholic Fatty Liver Disease
Study of Changes in Hepatic Fat Following Administration of MK-4074 and Pioglitazone Hydrochloride (MK-4074-008)
This study will evaluate changes in liver fat content following multiple oral doses of MK-4074 and Pioglitazone Hydrochloride in adult males and females with fatty liver disease.
- Trial name
- NCT01431521
- Testing
- MK-4074 200 mg, Pioglitazone hydrochloride 30 mg
- Volunteers
- 31 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes
Changes of Endothelial Function Before and After DSA in Patients With Diabetes
Endothelial dysfunction is the early step of atherosclerosis. Therefore, the investigators hypothesize that digital subtraction angiography (DSA) can damage endothelial function.
- Trial name
- NCT01556984
- Testing
- DSA assay
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Diabetes Mellitus Type 2 (T2DM)
Relationship Between Hemodynamic Changes and Cardiopulmonary Fitness in Type 2 Diabetes Mellitus Patients
Diabetes mellitus being metabolic disorder, chronic in nature, is characterized by high levels of glucose in our blood, which often lead to organ dysfunction.
- Trial name
- diabetes (NCT06842108)
- Testing
- Exercise tolerance test
- Where
- Pakistan
- Volunteers
- 162 people
- Sponsor
- Bahria University
Eco-anxiety
Pilot Study of a School Based Intervention for Coping With Climate Change
The present study aimed to evaluate the impacts of a school-based program that combined creative arts and philosophy inquiry to discuss climate change emotions with children.
- Trial name
- NCT07095387
- Testing
- Making room for climate emotions in the classroom
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Université du Québec a Montréal
Weight Loss, Appetite Loss
Role of Transcranial Direct Current Stimulation in Appetite and Weight Control
To study the effects of transcranial direct current stimulation (tDCS) on weight and appetite.
- Trial name
- TDCS (NCT05609604)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University at Buffalo
Maxillary Sinus Floor Augmentation, Maxillary Sinus Elevation
Assessment of a New Enhanced Xenograft in Open Maxillary Sinus Augmentation
Implant supported dental restorations are sometimes challenging with decreased bone height in the posterior maxilla. The goal of this study is to test an augmentation bone substitute in elevating the maxillary sinus floor; in…
- Conditions
- Maxillary Sinus Floor Augmentation, Maxillary Sinus Elevation, Bone Augmentation
- Trial name
- sinus (NCT07737704)
- Testing
- Xenograft, maxillary sinus membrane elevation and stabilization.
- Where
- 3 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Misr International University
Hyponatremia
Retrospective Analysis of ECG Changes and Arrhythmias in Patients With Profound Hyponatremia
The primary objective of this retrospective study is to determine the impact of hyponatremia on quantitative measurements and characteristics of the ECG.
- Trial name
- NCT07255833
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- University of Cologne
Hydrocephalus in Children, Epilepsy
Myelin Imaging Changes In Patients With Neurosurgical Diseases
Investigate myelin alterations in patients with neurosurgical diseases
- Conditions
- Hydrocephalus in Children, Epilepsy, Craniosynostoses, Traumatic Brain Injury
- Trial name
- McDESPOT (NCT03698838)
- Testing
- McDESPOT
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Memorial Healthcare System
Subthreshold Depression, Exercise
The Effect of Exercise on Cognition and Preventing Depression in Young People
It is estimated that approximately 30% of child and adolescents manifest subthreshold depression (including other specified depressive disorder and unspecified depressive disorder), which can further develop into major depression…
- Conditions
- Subthreshold Depression, Exercise, Clinically-well, Cognitive Change
- Trial name
- NCT04816617
- Testing
- Aerobic exercise intervention, Psycho-education
- Where
- China
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Physical Activity
WalkLink: Internet-based Walking Program
The investigators propose a randomized controlled trial based on the Social Networks for Activity (SNAP) Model to evaluate: (1) the effectiveness of an internet-based fitness walking program delivered to patients with risk…
- Trial name
- WalkLink (NCT01142804)
- Testing
- Group
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
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