Clinical trials: Modification
Cryotherapy Effect
Acute Effects of Cryotherapy on Muscle Properties
The main aim of this study is to investigate the acute effects of cryotherapy on muscle mechanical properties, muscle strength, and activation changes in healthy subjects.
- Trial name
- NCT06608836
- Testing
- an ice massage, the cold spray
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Disease, Chronic
Efficacy of Different Behaviour Change Techniques in MyPlan 2.0
The aim of this study is to investigate the effectiveness of intervention 'MyPlan 2.0' and the efficacy of the different behaviour change techniques that are included.
- Trial name
- NCT03274271
- Testing
- Action planning, Coping planning, Self-monitoring
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University Ghent
Post Operative Pain
Comparing Between Ultrasound Guided Pectoral Nerve Block Versus Ultrasound Guided Mid-point Transverse Process Block for Postoperative Analgesia in Patients Undergoing Modified Radical Mastectomy
The aim of the study is to compare the effectiveness of ultrasound guided pectoral nerve block versus mid-point transverse process block for postoperative analgesia in patients undergoing modified radical mastectomy
- Trial name
- NCT06873893
- Testing
- Midpoint transverse process block, Pectoral Nerve Block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Weight Loss
Does Meal Replacement With a Carbohydrates and Protein Supplement Induce Weight Loss in Overweight and/or Obese Adults?
Participants will be randomized into two groups, one group will be the control (no intervention at all) and the other will be CHO-PRO (meal replacement, Generation UCAN supplement, 400ml, 20% solution).
- Trial name
- NCT04458493
- Testing
- satiety, Dietary Supplement: Generation UCAN supplementation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Bruxism
Change in Biting Force After Botox Injection
Implant rehabilitation is a successful treatment option for edentulous patients. Decreasing bone loss around implants is an important target for all implantologists.
- Trial name
- NCT04940104
- Testing
- Botox Injectable Product
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Obesity
Digital Intervention for Behaviour Change and Chronic Disease Prevention
Body weight, diet quality, physical activity, stress, sleep and alcohol use will be evaluated in a sample of 180 Albertans with excess body weight.
- Trial name
- DIRECTION (NCT05579704)
- Testing
- Web-based wellness platform, Healthcare professional-facilitated online support group
- Where
- Canada
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Sacroiliac Dysfunction
Global Changes Associated With Sacroiliac Joint Dysfunction
Summary Sacroiliac joint dysfunction (ASI) is an alteration in the normal biomechanics of the joint, which leads to hypomobility or hypermobility of that joint.
- Trial name
- GCASID (NCT06687148)
- Testing
- Manual manipulation
- Where
- Portugal
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Aveiro University
Obesity, Depression
GLP-1 Medicines and Mental Health Changes
Key question: Is the use of GLP-1 weight loss medicines - semaglutide and tirzepatide - associated with improvements in mental health and health-related quality of life? Key finding: Across six- months of GLP-1 treatment…
- Conditions
- Obesity, Depression, GLP-1
- Trial name
- NCT07368855
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Diego
Glaucoma Open-Angle
Social History and Glaucoma Progression
The objective of this study is to predict of glaucoma progression. By imaging of the retinal nerve fiber layer RNFL, optic nerve head (ONH) and macular measurements using spectral-domain OCT (SD-OCT) instruments
- Trial name
- OCT (NCT06434155)
- Where
- Egypt
- Volunteers
- 1,584 people, healthy volunteers welcome
- Sponsor
- Assiut University
Neonatal Respiratory Failure
Development of Modified Combined Apgar Scoring System for Evaluation of Infants in the Delivery Room
Apgar scoring system has been widely used for the evaluation of the infant's postnatal condition. As conventional Apgar scoring system is affected by gestational age and resuscitative efforts, there is a need for development of…
- Trial name
- NCT03166826
- Testing
- Modified Apgar Scoring System
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pulmonary Disease, Infection
Leukocyte Morphological Parameters as Prognostic Markers in CAP
An innovative multicenter project that aims to study the evolution and predictive value of new leukocyte morphological parameters (CPD) in patients with community-acquired pneumonia.
- Trial name
- NCT04930926
- Where
- Spain
- Volunteers
- 1,200 people
- Sponsor
- Hospital Galdakao-Usansolo
Technology, Signs and Symptoms, Respiratory
The Effectiveness of Air Quality Sensor in Elderly Residential Setting
The study has 7 research questions regarding the use of the air quality sensor in residential care home for the elderly: Primary study questions: 1.
- Trial name
- NCT05837585
- Testing
- Air quality sensors
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Scleroderma, Diffuse
Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis
The purpose of this study is to evaluate the efficacy, safety and tolerability of rapcabtagene autoleucel (administered once following lymphodepletion) in participants with severe refractory diffuse cutaneous systemic sclerosis…
- Trial name
- NCT06655896
- Testing
- rapcabtagene autoleucel, rituximab
- Where
- 93 sites in United States, Argentina and 20 more
- Volunteers
- 96 people
- Sponsor
- Novartis Pharmaceuticals
Patient Safety Concerns
Using IF-THEN Plans to Support Healthcare Professionals in Raising Patient Safety Concerns
This study aims to test whether a brief behavioural intervention can help healthcare professionals raise and respond to patient safety concerns in their work.
- Trial name
- NCT07506096
- Testing
- Implementation intention planning
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Overweight
The Effect of a High Protein Diet on Body Weight Change During Post-partum
Nearly 20% of women do not return to their pré-gestacional body weight. The purpose of this study is to investigate the effect of diet and socio-demographics factors during gestation and postpartum period to body weight change…
- Trial name
- NCT00969488
- Testing
- High protein diet
- Where
- Brazil
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Alzheimer's Disease
Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation
The purpose of this study is to find a modified release oral tablet formulation for this drug, which will be safe and well tolerated.
- Trial name
- NCT02710188
- Testing
- HTL0009936 modified release, HTL0009936 immediate release
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Nxera Pharma UK Limited
Acute Heart Failure
Effect of Short-term Prednisone Therapy on C-reactive Protein in Patients With Acute Heart Failure
This is a multicenter, parallel-group, randomized, open-label, controlled trial. Patients with a diagnosis of acute heart failure (AHF) in the emergency department (ED) or after emergency presentation to hospital will be screened…
- Trial name
- CORTAHF (NCT05916586)
- Testing
- Prednisone
- Where
- 3 sites in Armenia
- Volunteers
- 101 people
- Sponsor
- Heart Initiative
Pelvic Organ Prolapse, Laparoscopy
Comparison of Laparoscopic Sacrohysteropexy, Modified Laparoscopic Lateral Suspension and Laparoscopic Pectopexy.
The aim of this study was to compare the results of laparoscopic sacrohysteropexy, laparoscopic modified lateral suspens9ion and laparoscopic pectopexy between January 2017 and December 2019 in our clinic.(Patients with at least…
- Trial name
- NCT04178083
- Testing
- medical examination
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Diyarbakir Women's and Children's Diseases Hospital
Diabetes Mellitus, Weight Loss
A Study to Evaluate the Pharmacokinetics of HRS9531 Injection in Participants With Mild, Moderate, and Normal Hepatic Function
This is a Phase I clinical study to compare the pharmacokinetics (PK) of HRS9531 Injection in participants with mild/moderate hepatic impairment and participants with normal hepatic function, and to evaluate the safety of HRS9531…
- Trial name
- NCT07540754
- Testing
- HRS9531 Injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Painful Bladder Syndrome, Interstitial Cystitis
Clinical Efficacy of Changing the InterStim® Parameters in Patients With Interstitial Cystitis/Painful Bladder Syndrome
Purpose: 1. To demonstrate better symptoms control (pain, urinary urgency and frequency) with sacral neuromodulation (SNM) in patients with interstitial cystitis /painful bladder syndrome (IC/PBS) using a stimulation frequency of…
- Conditions
- Painful Bladder Syndrome, Interstitial Cystitis, Pelvic Floor; Insufficiency, Bowel Dysfunction
- Trial name
- NCT01312259
- Testing
- Changing the Interstim parameter of '' Frequency" in patients with Interstitial Cystitis
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Pelvic and Sexual Health Institute
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