Clinical trials: Modification
Diarrhea, Cough
Asili Evaluation in the Democratic Republic of Congo
The South Kivu province of DRC has experience continuous armed conflict over the last several decades; as a result, livelihoods and health metrics are uniformly poor.
- Conditions
- Diarrhea, Cough, Fever, Malnutrition, Child
- Trial name
- NCT03536286
- Testing
- Encouragement
- Volunteers
- 9,999 people, healthy volunteers welcome
- Sponsor
- Stanford University
Retrospective Study, Glioma
[18F]FET PET for Characterization of Progressive or Recurrent Glioma From Treatment Related Changes
This study is designed to prospectively analyze [18F]FET PET image data obtained retrospectively in the routine clinical care of glioma patients.
- Conditions
- Retrospective Study, Glioma, Brain Neoplasms
- Trial name
- NCT07238322
- Testing
- 18F(FET)PET
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 253 people
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Limited
Overweight and Obesity
Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment
Obesity has become an important public health issue that leads to insulin resistance, diabetes, hypertension, dyslipidemia, and cardiovascular diseases.
- Trial name
- NCT06069622
- Testing
- 24-hour ambulatory blood pressure, Liberal salt diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Prostatic Neoplasm
Prevention of Metabolic Syndrome and Increased Weight Using Metformin Concurrent to Androgen Deprivation Therapy and Radiotherapy for Locally Advanced Adenocarcinoma of the Prostate
In current clinical practice, an acceptable standard treatment for locally advanced prostate cancer is radiation therapy in combination with hormone therapy (called Treatment B or Group B in this study).
- Trial name
- PREMIUM (NCT01996696)
- Testing
- Metformin
- Where
- 3 sites in Canada
- Volunteers
- 83 people
- Sponsor
- AHS Cancer Control Alberta
Forward Head Posture
Electromyographic Effects of Postural Correction Exercises in Individuals With Forward Head Posture
This study investigates the effects of specific corrective exercises on EMG of masticatory and cervical muscles in individuals with forward head posture.
- Trial name
- NCT07780396
- Testing
- Specific strengthening and stretching exercise, General Exercise
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Cairo University
Periodontitis
10 Year Follow up of RCT Comparing Different Regenerative Regenerative Procedures
Evaluate the 10-year stability clinical, radiographic outcomes obtained with the application of the modified minimally invasive surgery to deep pockets associated with intrabony defects.
- Trial name
- NCT05225142
- Testing
- Modified minimally invasive surgery, Modified minimally invasive surgery with enamel matrix derivative, Modified minimally invasive surgery with enamel matrix derivative and bone replacement graft
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- The European Research Group on Periodontology (ERGOPerio)
Valve Disease, Heart
Early Resistance Training Post Valve Replacement Surgery
Background: Recent recommendations from the European Society of Cardiology (ESC) are multidisciplinary cardiac rehabilitation including therapeutic exercises for patients after heart valve surgery unless there is insufficient…
- Trial name
- NCT05846386
- Testing
- Resistance training, Aerobic training
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Obesity, Weight Loss
Weight Loss Study-Mechanism Underlying the Improvement of Insulin Resistance in Response to Weight Loss
The main purpose of this study is to assess factors mediating the changes in insulin sensitivity and glucose tolerance before and after 10 lbs ± or 2% weight loss reduction as well as 2, 3, 6, 12, and 24 months after initiation…
- Trial name
- NCT01780870
- Testing
- Weight loss group (Full meal replacement products)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy, Febrile
Comparison of a Novel Non-Invasive, Non-Touch Infrared Thermometer With Routine Thermometry in Routine Clinical Practice
Quantify the reliability and agreement of estimated core body temperature using the InstaTemp MD™ and other widely marketed reference Thermometers
- Trial name
- NCT02805322
- Testing
- ARC InstaTemp MD, Covidien Genius 2 Tympanic Thermometer, Welch Allen SureTemp Plus Sublingual Thermometer
- Where
- Ireland
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- ARC Devices
Obesity and Overweight
Plant-Based Foods and (Poly)Phenol Supplementation in Gut Microbiota Modulation, Body Weight, and Cardiometabolic Risk
This single-blind, randomized controlled trial aims to evaluate the effects of increased dietary polyphenol intake-either through a healthy plant-based diet (PBD) or supplementation-on body weight and cardiometabolic risk factors…
- Trial name
- PREDIET-ARAC (NCT06911346)
- Testing
- Diet supplementation, Polyphenol-rich supplement
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Universidad Catolica de Temuco
Complete Edentulism
Effect of Different Implant Surface Treatments on Bony Changes Around Mandibular Implants
The research will be conducted to report which type of surface treatment of dental implants that can be successful and aids in increasing bone to implant contact and how it affects the bony changes around the implants installed…
- Trial name
- NCT04686370
- Testing
- laser treated implant surface
- Where
- Egypt
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cairo University
Urinary Bladder, Overactive
Study The Effects Of Different Doses Of UK-369,003 In Men With Overactive Bladder
This is a 12 week study in which different doses of UK-369,003 will be administered to patients with a diagnosis of overactive bladder.
- Trial name
- NCT00479505
- Testing
- UK-369,003
- Where
- 52 sites in Australia, Canada and 14 more
- Volunteers
- 275 people
- Sponsor
- Pfizer
Major Depressive Disorder, Soft Tissue Discomfort Syndrome
Functional Change and Efficacy of Duloxetine in Patients With Co-Morbid Depression & Soft Tissue Discomfort Syndrome
The objective of this study is to determine the time course of duloxetine efficacy on the symptoms of Major Depressive Disorder (MDD)and on the symptoms of Soft Tissue Discomfort Syndrome(STDS) via use of 24-hour Actigraph™…
- Conditions
- Major Depressive Disorder, Soft Tissue Discomfort Syndrome, Pain
- Trial name
- NCT01035073
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pennsylvania
Obesity, Weight Loss
Long-Term Effect of 10 mg Versus 20 mg Rimonabant in Overweight or Obese Patients
The primary objective of this study is to assess, over a period of 12 months, the effect on weight loss and weight maintenance of rimonabant 10 mg in comparison with rimonabant 20 mg in overweight/obese patients after an initial…
- Trial name
- MODERATO (NCT00678483)
- Testing
- rimonabant (SR141716)
- Where
- 5 sites in Croatia, Finland and 3 more
- Volunteers
- 331 people
- Sponsor
- Sanofi
COPD, Chronic Lung Disease
Does Pulmonary Rehabilitation Change Self-Selected And Maximum Sustainable Walking Speed In Patients With Lung Disease?
Exercise training has been shown to reduce breathlessness and improve the exercise tolerance of people with lung disease. However, the effect of exercise training on the walking speed selected by these people during day-to-day…
- Trial name
- NCT00781183
- Testing
- pulmonary rehabilitation
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- West Park Healthcare Centre
Obesity, PreDiabetes
Mechanisms of Inflammation, Immunity, Islet Cell and Intestinal Hormone Changes in Youth at Risk for Diabetes
This study intends to assess the role of inflammation in insulin resistant conditions (i.e., obesity and pre-diabetes) and the subsequent development of disease, such as type 2 diabetes (T2D) and cardiovascular disease (CVD), in…
- Conditions
- Obesity, PreDiabetes, Adolescent Obesity, Inflammation
- Trial name
- MI4D (NCT04031222)
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- The Hospital for Sick Children
Famine
Band Holiday Study
AIMS: Our aims are to measure BMI and plasma concentrations of representative hormones before and after a band holiday, in addition to surveying hunger/satiety and behavior changes.
- Trial name
- NCT00967122
- Testing
- Band adjustment and specimen collection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Sickle Cell Disease, Cognitive Impairment
Minocycline In Neurocognitive Outcomes - Sickle Cell Disease
Sickle cell disease (SCD) is a common, inherited blood disorder that primarily affects people of African Ancestry. It has a lot of complications including neurological complications.
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Cognitive Decline, Cognitive Change
- Trial name
- MINO-SCD (NCT05605366)
- Testing
- Minocycline
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Morbid Obesity
Changes in Incretines, Gut Hormones and Bile Acids After Roux-en-Y Gastric Bypass
Obesity is an increasing world wide problem. Moreover, the increase in patients who are considered morbidly obese is even higher (Sturm et al, Healt Aff 2004).
- Trial name
- NCT03384303
- Testing
- Standardized meal test
- Volunteers
- 10 people
- Sponsor
- Rijnstate Hospital
Hypothermia; Anesthesia
enFlow IV Fluid and Blood Warming System
This study is part of a post-market clinical follow-up (PMCF). The purpose of this study is to verify in a routine clinical environment with a number of caregivers and subjects that the enFlow performs as intended when used as an…
- Trial name
- NCT04709627
- Testing
- enFlow IV Fluid and Blood Warming System
- Where
- 2 sites in Finland
- Volunteers
- 50 people
- Sponsor
- Vyaire Medical
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