Clinical trials: Modification
Kidney Neoplasms, Metastatic Renal Cell Cancer
Study to Assess Various Sunitinib Schedules in Renal Cell Carcinoma
Patients who are candidates for first line treatment with Sunitinib 50mg 4/6 regimen in accordance with the Marketing Authorisation who meet the inclusion/exclusion criteria will be offered participation in this study during the…
- Trial name
- SURF (NCT02689167)
- Testing
- Sunitinib
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Traumatic Brain Injury (TBI), Agitated Behaviour
Modified Environment for Agitation in Patients With TBI
This study examines the effect of an intervention consisting of dynamic circadian light and sound therapy, as well as systematic information on sleep pattern, agitated behavior and functioning level.
- Trial name
- ABS (NCT02524067)
- Testing
- Multifactorial circadian concept
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Carcinoma, Non-Small-Cell Lung, Bronchial Neoplasms
Dynamic Changes of Circulating Tumor DNA in Late Stage NSCLC Patients
A multi-centre observational, non-interventional study is to dynamically monitor the changes of circulating tumor DNA (ctDNA) in late stage NSCLC patients under Gefitinib treatment.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Bronchial Neoplasms, Carcinoma, Bronchogenic, Lung Diseases
- Trial name
- NCT02804100
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Wenzhou Medical University
Hemodialysis, Cerebral Blood Flow
Association Between Cerebral Blood Flow Change and Cognitive Function in Hemodialysis Patients
The prevalence of cognitive impairment in maintenance hemodialysis (MHD) patients is 3 to 5 times higher than that in ordinary people, so it is essential to find the associated risk factors in this population.
- Conditions
- Hemodialysis, Cerebral Blood Flow, Cognitive Function, Magnetic Resonance Imaging
- Trial name
- NCT05555836
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Cesarean Section
Efficacy of Modified Perichondral Approach Thoracoabdominal Nerve Block For Post Cesarean Section
Cesarean section (CS) is one of the most frequently performed surgical procedures in the World. Moderate to severe postoperative pain occurs in a significant proportion of women after cesarean surgery.
- Trial name
- NCT06078475
- Testing
- Postoperative analgesia management
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa City Hospital
Adapted Physical Activity and Cancer
Adapted Physical Activity in a Chemotherapy Ambulatory Care Unit: Feasibility and Impact on Fatigue, Anxiety and Depression in Cancer Patients
Physical activity has demonstrated efficacy in cancer prevention and improves quality of life and outcome in cancer survivors. Patients undergoing chemotherapy, especially those with advanced disease, may have symptoms leading to…
- Trial name
- UMACHAPA (NCT03049436)
- Testing
- Program of adapted physical activity
- Where
- France
- Volunteers
- 250 people
- Sponsor
- CHU de Reims
Breast Cancer
Effect of Bazedoxifene, Raloxifene, and Placebo on Breast Density
It has been shown that women who have dense breasts have an increased risk of breast cancer compared with women whose breasts are less dense.
- Trial name
- NCT00418236
- Where
- 37 sites in United States, Argentina and 12 more
- Volunteers
- 400 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Neuralgia Peripheral, Pain
Cognitive Changes With Gabapentin Treatment
This is a single-cohort, prospective, observational study evaluating the effects of gabapentin on cognition. The goal of the study is to determine whether there is a measurable change in cognitive function from baseline in…
- Trial name
- NCT04106011
- Testing
- Gabapentin, BTACT, BPI
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Washington University School of Medicine
Schizophrenia
Roflumilast Plus Antipsychotics Proof of Mechanism Study in Schizophrenia
The purpose of this study is to determine whether cognitive impairment associated with schizophrenia is attenuated by add-on roflumilast administration to second generation antipsychotics (SGA) in participants with stable…
- Trial name
- NCT02079844
- Testing
- Roflumilast, Second generation antipsychotic
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Takeda
Obesity; Endocrine, Diabete Type 2
Molecular, Metabolomic and Nutritional Changes After Metabolic Surgery
Obesity is a major risk factor for Type 2 Diabetes (T2D) and cardiovascular diseases, such as hypertension and dyslipidemia. Recently, weight loss surgery (i.e., metabolic or bariatric surgery) has been shown to result in very…
- Conditions
- Obesity; Endocrine, Diabete Type 2, PreDiabetes
- Trial name
- MoMen (NCT05322551)
- Where
- Malaysia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Malaysia
Obsessive-Compulsive Disorder, Cognition Disorders
Physical Exercise in OCD: Treatment Efficacy, Additive Benefits to CBT, and Cognitive Correlates of Change
Obsessive compulsive disorder (OCD) is a severe and debilitating anxiety disorder afflicting 2% of the population. Cognitive behavioural therapy (CBT) is considered first line psychological treatment for OCD, but there are a…
- Trial name
- NCT02136953
- Testing
- Exercise, Cognitive Behavioural Therapy (CBT)
- Where
- 3 sites in Canada
- Volunteers
- 125 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cellulite
Structural Changes of Subcutaneous Tissue by Ultrasonographies in Patients After Treatment With PnKCelulitis® Program
Exploratory, prospective, uncontrolled and single-blinded pilot study, with clinical and ultrasound assessments of cutaneous cellulite before and after treatment with a specific multidisciplinary programme following dietary…
- Trial name
- PnKCelulitis (NCT03550157)
- Volunteers
- 20 people
- Sponsor
- Protein Supplies SL
Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And Antagonist
The purpose of this study is to test the hypothesis that patients with non-neuropathic POTS will have different responsiveness than patients with neuropathic POTS to direct alpha-1 adrenoreceptor agonist therapy (droxidopa) and…
- Trial name
- NCT03070730
- Testing
- Droxidopa, Atenolol
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Beth Israel Deaconess Medical Center
Colonic Adenomatous Polyps
Effectiveness and Safety of the Endoscopic Removal of Large and Flat Colonic Polyps With LumenR RetractorTM
Colorectal cancer accounted for 142,570 new cancer cases and 51,370 cancer deaths in USA in 2010 and worldwide has become the third most common cancer and second leading cause of cancer related deaths.
- Trial name
- NCT02051465
- Testing
- LumenR Retractor, Removal without overtube
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mercy Medical Center
Head and Neck Carcinoma
IAEA-HypoX. Accelerated Radiotherapy With or Without Nimorazole in Squamous Cell Carcinoma of the Head and Neck
The purpose of this study is to test the hypothesis that radiotherapy of head and neck carcinoma can be improved by hypoxic modification of radiotherapy using nimorazole as a hypoxic radiosensitizer in association with…
- Trial name
- IAEA-HypoX (NCT01507467)
- Testing
- Accl. RT, Accl. radiotherapy + Nimorazole
- Where
- 6 sites in Egypt, Estonia and 2 more
- Volunteers
- 104 people
- Sponsor
- Danish Head and Neck Cancer Group
Obesity
Protocol for a Feasibility of a Motivational Interviewing for Weight Loss in Adults
Abstract Introduction: This pilot study will determine the recruitment feasibility, retention, and adhesion for a motivational interviewing program for weight loss in adults according to the processes of change in weight loss.
- Trial name
- MWL (NCT05769907)
- Testing
- Intervention Group
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Aging, Low DHEA for Women
DHEA and Testosterone Replacement in Elderly
Sarcopenia is a major health problem among the rapidly expanding elderly population in our society. Disabilities directly related to muscle weakness, and indirectly related to changes in body composition and metabolic…
- Conditions
- Aging, Low DHEA for Women, Low Testosterone and DHEA for Men
- Trial name
- NCT00254371
- Testing
- Androgen Replacement
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
HBV, HBV Coinfection
Changes in Bile Acids and Microbiota in Patients With Hepatitis D Treated With Bulvertide
HDV is an RNA virus that infects only in the presence of HBV, affecting about 13% of HBsAg carriers. In Italy, prevalence ranges from 3.2% to 9.3%.
- Conditions
- HBV, HBV Coinfection, HCV, HIV Infections
- Trial name
- Bio-Delta (NCT07429864)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hemodynamics Instability, Prone Position
Hemodynamic Changes Due to Prone Position
Perioperative prone position may be associated with hemodynamic instability. The causes of instability have not yet been precisely elucidated.
- Trial name
- NCT04491331
- Testing
- prone position
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital Hradec Kralove
Healthy Volunteers
Physiological Changes Exploration During the Hypnotic State
Use of hypnosis for therapeutic purposes tends to spread. However, the neural mechanisms underlying hypnosis is still debated and no specific change has yet been associated with this state.
- Trial name
- HYPNOTE (NCT04020731)
- Testing
- Hypnosis
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.