Clinical trials: Modification
Parkinson's Disease, Deep Brain Stimulation
Predicting Cognition After DBS for Parkinson's Disease
The aim of the study is to improve estimation of cognitive outcome after STN-DBS in PD in order to avoid risk factors by optimizing peri- and intraoperative management personalize therapeutic strategies for optimal long-term…
- Conditions
- Parkinson's Disease, Deep Brain Stimulation, Postoperativeneurocognitive Deficit, Postoperative Delirium
- Trial name
- NCT03982953
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Weight Loss
Exercise Time in Sedentary Middle-aged Female
The exercise time is an important factor among the medical guides for weight loss; however, there is still little knowledge about exercise duration paths in middle-aged and older women.
- Trial name
- NCT01851837
- Testing
- Exercise time
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- P.L.Shupik National Medical Academy of Post-Graduate Education
Ptosis, Eyelid, Ptosis; Eyelid, Congenital
Modified Müller's Muscle-conjunctival Resection Internal Ptosis Repair Using Fibrin Glue
Fibrin glue is widely used in ophthalmology for homeostasis and tissue recovery. It is commonly used in ocular surface surgeries such as pterygium removal and conjunctival lesions excisions.
- Conditions
- Ptosis, Eyelid, Ptosis; Eyelid, Congenital, Surgical Procedure, Unspecified
- Trial name
- NCT03392272
- Testing
- Using of Tisseel fibrin glue, Using sutures
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Eating Behavior
Al Dente or Well Done? The Eating Rate of a Pasta Meal Modified by Texture
Rationale: The world-wide rising obesity rates are a major health problem. Therefore, people should moderate food intake. A lower eating rate will decrease the energy intake.
- Trial name
- ESPA (NCT05019872)
- Testing
- (Components of) pasta meal
- Where
- Netherlands
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Myocardial Injury, Cardiac Surgery
Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
The aim of the present study was to investigate intra-operative changes in markers of myocardial injury and myocardial intracellular amino acids during ischemia and reperfusion, comparing two methods of myocardial protection…
- Conditions
- Myocardial Injury, Cardiac Surgery, Myocardial Protection
- Trial name
- NCT06287372
- Testing
- Cardioplegic solution
- Where
- Syria
- Volunteers
- 20 people
- Sponsor
- Damascus University
Body Temperature Changes, Heat Stress
Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers performing physically demanding work in hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07664462
- Testing
- Simulated Occupational heat exposure under normoxic conditions, Simulated Occupational heat exposure under hypoxic conditions
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Ottawa
Class I/II Obesity
Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss
The goal of this clinical trial is to learn about the nature of brain abnormalities associated with excess body fat in healthy adults aged 35-55.
- Trial name
- THRIVE (NCT07592546)
- Testing
- semaglutide
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Alain Dagher
Pain, Acute
Distraction as Treatment for Pain in Children in Resource-scarce Settings
Pain alleviation in pediatric patients can be challenging for medical professionals working in resource scarce settings due to limited availability of medication, monitoring equipment, or training in this field of expertise.
- Trial name
- DISTRACT (NCT06933303)
- Testing
- Distraction with kaleidoscope
- Where
- South Africa
- Volunteers
- 126 people
- Sponsor
- Vrinnevi Hospital
Male Infertility, Obesity
Investigating the Physiological Effects of Weight Loss on Male Fertility
The purpose of this study is to determine the physiological effects of weight loss on seminal parameters in male participants with reduced reproductive capacity.
- Conditions
- Male Infertility, Obesity, Weight Loss
- Trial name
- NCT03553927
- Testing
- Low Energy Diet, NHS advice on healthy eating
- Where
- United Kingdom
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Anterior Cruciate Ligament Injuries
ALL Reconstruction Versus Modified Lemaire's LET in Combination With ACL Reconstruction With a Minimum Follow up of 2 Years
Anterior cruciate ligament (ACL) tears are associated with concomitant lesions of the anterolateral ligament (ALL), which increase rotatory instability of the knee.
- Trial name
- ARAVET (NCT06147427)
- Testing
- ACL reconstruction with hamstrings combined with ALL plasty, ACL reconstruction with hamstrings combined with modified Lemaire's LET
- Where
- France
- Volunteers
- 248 people
- Sponsor
- Hospices Civils de Lyon
Health Behavior
My Health Coach Study
The "My Health Coach Study" seeks to determine if health coaching by a medical assistant can help patients have better sleep, a better diet, be more physically active or lose weight, according to the recommendation of their…
- Trial name
- NCT02201069
- Testing
- health coaching
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Palatal Expansion Technique
Evaluation of Hard and Soft Tissue Change During Maxillary Expansion Using a Computer-aided Design / Computer-aided Manufacturing Appliance.
Hard tissue changes during the transversal expansion of the maxilla using a CAD/CAM expansion appliance. Soft tissue changes during the transversal expansion of the maxilla using a CAD/CAM expansion appliance.
- Trial name
- NCT06246656
- Testing
- Maxillary Expansion
- Where
- Austria
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Non-Alcoholic Fatty Liver Disease, Dietary Modification
Chia Supplementation and Non Alcoholic Fatty Liver Disease
Parallel to epidemic obesity, non-alcoholic fatty liver disease (NAFLD) prevalence has markedly increased during the last years, and recent data point out that one of three adults courses with this disease.
- Trial name
- NCT03942822
- Testing
- Milled chia seeds
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Rheumatoid Arthritis
Clinically Important Changes in Rheumatoid Arthritis
This study will explore how patients with rheumatoid arthritis evaluate, or rate, symptom improvements. Physicians generally evaluate patients health and treatment benefits based on laboratory measures, such as the number of…
- Trial name
- NCT00056602
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
COPD Exacerbation
A Feasibility Study of Wearable Device in Assessing Respiratory Condition Change of Patients With Exacerbation of COPD
The study will include daily SenseGuard measurement of patients hospitalized with exacerbations of COPD. from admission to discharge.
- Trial name
- NCT05153122
- Testing
- SenseGuard
- Where
- 2 sites in Germany, Israel
- Volunteers
- 15 people
- Sponsor
- NanoVation
Cerebral Palsy, Spastic, Telemedicine
The Feasibility of Telehealth HEP for CP (HEP: Home Exercise Program), (CP: Cerebral Palsy)
This study will provide exercise videos and live consultation sessions for adolescents with spastic cerebral palsy. We will recruit 20 participants with 10-18 years old and will be randomized into an experimental or control…
- Trial name
- HEPCP (NCT04423653)
- Testing
- Telehealth home exercise program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Kansas Medical Center
Multiple Sclerosis (MS), Inflammatory Disease
The Inflammatory Process and the Medical Imaging in Patients With an Inflammatory Disease of the Central Nervous System.
While significant progress has been made on medical imagery in recent years in the individualization of different lesions in the nervous system for demyelination, axonal loss, atrophy, little progress has been made in the…
- Trial name
- USPIO-CIS (NCT01567553)
- Testing
- USPIO MRI - Gadolinium MRI
- Where
- 5 sites in France
- Volunteers
- 37 people
- Sponsor
- Rennes University Hospital
Bulimia Nervosa, Eating Disorder
Rapid Response to Day Hospital Treatment in Bulimia Nervosa and Purging Disorder
Treatments for bulimia nervosa (BN) have relatively high rates of nonremission and relapse, meaning that improving treatments is a high priority in this area.
- Trial name
- CBT-RR (NCT02444065)
- Testing
- Cognitive Behavior Therapy (CBT), Motivational Interviewing (MI)
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
Postoperative Pain, Postoperative Vomiting and Nausea
Efficacy Side-effect Score (ESS): Development and Evaluation of a New Tool for Patients After Surgery
We hypothesized that better control of postoperative pain treatment and its side effects by monitoring ESS might influence the degree of mobility and morbidity in surgical patients and consequently reduce LOS.
- Conditions
- Postoperative Pain, Postoperative Vomiting and Nausea, Postoperative Complications, Mental Status Changes Postoperative
- Trial name
- ESScore (NCT02143128)
- Testing
- Efficacy Safety Score, Verbal Numeric Rating Scale
- Where
- 2 sites in Kazakhstan, Russia
- Volunteers
- 1,152 people, healthy volunteers welcome
- Sponsor
- Vestre VikenHF Kongsberg Sykehus
Health Behavior
A Co-creational Intervention to Engage Preschoolers in Healthy Movement Behaviors
Previous research focusing on preschoolers' healthy behaviors looked at developing interventions for separate behaviors, such as physical activity and sedentary behavior.
- Trial name
- NCT06073236
- Testing
- The healthy day-project
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Ghent
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