Clinical trials: Modification
Coronary Artery Disease, Myocardial Infarction
Impact of a Corrie Cardiac Rehabilitation Program
In this randomized clinical trial, the researchers are investigating whether a multi-component virtual/hybrid cardiac rehabilitation program will improve functional status, cholesterol level, overall cardiovascular health…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Myocardial Ischemia, Coronary Artery Occlusion
- Trial name
- mTECH-Rehab (NCT05238103)
- Testing
- Corrie Hybrid Cardiac Rehabilitation Program
- Where
- United States
- Volunteers
- 259 people
- Sponsor
- Johns Hopkins University
Platelet Changes in Cases of Iron Overload
Platelet Changes in Cases of Chronic Iron Over Load
Iron demand: The average daily demand to fit the cell biological metabolism is balanced between intake and lost which about 1-2 mg.
- Trial name
- NCT04329286
- Volunteers
- 50 people
- Sponsor
- Assiut University
Parkinson Disease
Ambroxol in Disease Modification in Parkinson Disease
This study will evaluate the safety, tolerability and pharmacodynamics of ambroxol in participants with Parkinson Disease. Participants will administer ambroxol at five dose levels and will undergo clinical assessments, lumbar…
- Trial name
- AiM-PD (NCT02941822)
- Testing
- Ambroxol
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University College, London
Heart Failure
CHANges iN skEletal muscLe in Heart Failure
The mechanisms behind heart failure are largely unknown. Despite an increasing arsenal of pharmacological therapies, cardiovascular disease is still the most common cause of death in the western world, which demonstrates a…
- Trial name
- Channel-HF (NCT03401151)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
End Stage Renal Failure on Dialysis
Impact of Cold Dialysis in Combination With Intradialytic Exercise in Aspects Related to Quality of Life and Health
Despite the tremendous advances in dialysis technology, hemodialysis (HD) is a significant challenge for dialysis patients and quality of their lives[2].
- Trial name
- REACD (NCT03905551)
- Testing
- Cold Dialysis, Typical Dialysis, Exercise
- Where
- 3 sites in Greece
- Volunteers
- 72 people
- Sponsor
- University of Thessaly
Crohn's Disease
Role of Capsule Endoscopy in the Evaluation of Mucosal Changes During Treatment of Patients With Active Crohn's Disease
The utility of capsule endoscopy in diagnosing small bowel (SB) Crohn's disease has been demonstrated in a number of studies. Mucosal healing is a good predictor of long term remission.
- Trial name
- CHANCE (NCT02193802)
- Testing
- PillCam® COLON 2 and PillCam Crohn's capsules
- Where
- 11 sites in France, Spain
- Volunteers
- 42 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Smallpox
Phase 2 Study of Safety, Tolerability, and Immunogenicity of Three Dose Levels of ACAM3000 Smallpox Vaccine
A phase 2 study to assess the MVA smallpox vaccine in previously vaccinated and vaccine- naive subjects at three dose levels.
- Trial name
- NCT00466245
- Testing
- MVA Smallpox vaccine
- Volunteers
- 590 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Breast Cancer, Neoadjuvant Therapy
Validation of the CPS+EG, Neo-Bioscore and Modified Neo-Bioscore Staging Systems After PST of BC in China
Prognostic assessment after preoperative systemic therapy (PST) plays a vital role in breast cancer patients. The clinical-pathologic staging system incorporating estrogen receptor (ER)-negative disease and nuclear grade 3 tumor…
- Conditions
- Breast Cancer, Neoadjuvant Therapy, Neoplasm Staging, Estrogen Receptor
- Trial name
- NCT03437837
- Where
- 12 sites in China
- Volunteers
- 1,077 people
- Sponsor
- Peking University First Hospital
Chronic Low-back Pain
Does the Therapist's Assessment of Movement Control in Low Back Pain Patients Correspond to an Objective Kinematic Modification
Exercise-based treatment is part of the recommendations for good practice in the treatment of low back pain (acute, sub-acute and chronic). The low back pain population is heterogeneous.
- Trial name
- LOBACOM (NCT05511012)
- Testing
- motion control fault tests
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Brest
Opioid-Related Disorders, Parent-Child Relations
Modified ABC: A Home-based Parenting Program for Opioid-dependent Mothers and Their Infants
This study will assess the efficacy of the modified Attachment and Biobehavioral Catch-Up Intervention, adapted for use with peripartum mothers receiving medication-assisted treatment for opioid use disorder.
- Conditions
- Opioid-Related Disorders, Parent-Child Relations, Infant Development, Parenting
- Trial name
- mABC (NCT03891628)
- Testing
- Modified Attachment and Biobehavioral Catch-up, Modified Developmental Education for Families
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Delaware
Chronic Kidney Disease - Stage V
Adipose Tissue & Uremia
Many metabolic disturbances, such as protein-energy wasting, inulin resistance, and dyslipidemia are common features of chronic kidney disease (CKD).
- Trial name
- MODAIR (NCT02902705)
- Testing
- Biopsy of abdominal subcutaneous white adipose tissue (2-3 g)
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Hospices Civils de Lyon
Pediatric Obesity
Factors Associated With Changes in Weight-status in Danish School Children With Obesity
Childhood obesity is increasing worldwide and causes a major health concern. Only limited insight exists into the natural history of childhood obesity at children already classified as obese.
- Trial name
- NCT06077266
- Testing
- Change of weight class to normal weight
- Where
- Denmark
- Volunteers
- 467 people
- Sponsor
- University of Aarhus
Fever
Comparative Efficacy of Single-dose Doxycycline Versus Standard 5- Day Amoxicillin Treatment
Abstract: Background The current practice in Senegal is to use broad-spectrum antibiotics including amoxicillin and/or cotrimoxazole in case of non-malarial fevers. First-line treatment with doxycycline has cured such patients.
- Trial name
- NCT03765931
- Testing
- Doxycycline, Amoxicillin
- Where
- Senegal
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Osteoporosis
CR9112792, a Follow-up of Study CR9108963
The purpose of this study is to determine whether bone mineral density has increased in a subgroup of postmenopausal osteoporotic women from study CR9108963, between 6 and 12 months following cessation of ronacaleret therapy.
- Trial name
- NCT00891553
- Testing
- DXA
- Where
- 3 sites in Denmark, Norway
- Volunteers
- 171 people
- Sponsor
- GlaxoSmithKline
Periodontal Pocket
Gingival Crevicular Fluid Bone Morphogenetic Protein - 2 Release Profile Following the Use of Perforated Membrane
One of the most important elements suggested to be provided through membrane perforations to augment regeneration are cell released growth factors from the overlying periosteal and gingival cells.
- Trial name
- MPM (NCT01860495)
- Testing
- perforated membrane, G2
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Insomnia, Digestive Endoscopy
Changes in Etomidate Dosage in Patients With Insomnia Undergoing Intravenous Anesthesia
To compare the dosage requirement of etomidate under intravenous anesthesia between patients with insomnia and those with normal sleep pattern.
- Trial name
- NCT07028177
- Testing
- No interventions, it is a observational study
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Beijing Tiantan Hospital
Traumatic Brain Injury (TBI) Patients, Neuroinflammation
Vitamin D3 for Moderate to Mild Traumatic Brain Injury: A Randomized Trial on Inflammation and Recovery (VIMOT)
This study is a Phase II, randomized, quadruple-blinded, placebo-controlled clinical trial designed to test whether vitamin D₃ supplementation can improve recovery after mild-to-moderate traumatic brain injury (TBI) in adults.
- Trial name
- VIMOT (NCT07269457)
- Testing
- Vitamin D3 (Cholecalciferol)
- Where
- Nigeria
- Volunteers
- 240 people
- Sponsor
- Lagos State University
Anxiety State, Efficacy, Self
Video-based Climate Change Program
Climate change represents a global crisis with far-reaching implications for health, including mental health. Among vulnerable populations, such as nursing students, climate change anxiety is emerging as a noteworthy concern.
- Trial name
- NCT06223412
- Testing
- video-based climate change program
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Sleep Apnoea, Obesity & Overweight
Tirzepatide Versus Positive Airway Pressure for the Treatment of Obstructive Sleep Apnoea
When used, continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea (OSA), a condition that is mainly caused by overweight and obesity.
- Conditions
- Sleep Apnoea, Obesity & Overweight, Sleep Apnea Syndrome, Obstructive
- Trial name
- TIRZE-PAP (NCT07846865)
- Testing
- Continuous Positive Airway Pressure, Tirzepatide
- Where
- Australia
- Volunteers
- 256 people
- Sponsor
- Woolcock Institute of Medical Research
Parastomal Hernia
Evaluation of the Parietex TM Parastomal No Hole Mesh for Repair of Parastomal Hernias in End-colostomies
Short Title: PHARAOH study: LAPAROSCOPIC PARASTOMAL HERNIA REPAIR WITH A NO HOLE MESH. Objectives: Evaluation of operative complications, colostomy function, Quality of Life and recurrence rate after laparoscopic repair of…
- Trial name
- PHARAO (NCT04966065)
- Testing
- Parietex Parastomal mesh
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
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