Clinical trials: Modification
Asthma
Pilot of Lifestyle and Asthma Intervention
This is to pilot test a weight loss intervention in obese patients with poorly controlled asthma. Obesity is a risk factor for the development of asthma (approximately 250,000 cases per year of asthma in the U.S.
- Trial name
- PLAN (NCT03291808)
- Testing
- Weight loss intervention
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Johns Hopkins University
Obesity
fMRI and Appetite-Related Hormones Pre and Post Obesity Surgery
The investigators are looking at the differences in appetite and obesity between weight loss participants and patients undergoing bariatric surgery.
- Trial name
- NCT01583725
- Testing
- Liquid meal responses, fMRI responses to food-cues
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- New York Obesity and Nutrition Research Center
Pregnancy, Labor Pain
Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes
Fetal heart rate patterns are an important parameter in the diagnosis of non-reassuring fetal status. Combined-spinal epidural analgesia is a method of initiating labor analgesia used by approximately 90% of the parturients at…
- Trial name
- NCT02121184
- Testing
- Routine oxytocin, Half-dose oxytocin
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Overweight and Obesity, Metabolic Syndrome
Changes in the Hypotalamic-pituitary Region of Patients With Metabolic Syndrome and Obesity
This study aims to identify new morphological and quantitative magnetic imaging parameters of pituitary gland and sellar region in overweight and obese patient at baseline and after 3 years, dividing patients in 3 groups (weight…
- Trial name
- CHIASM (NCT03458533)
- Testing
- Bariatric surgery, Diet and lifestyle changes
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- University of Roma La Sapienza
Childhood Obesity, Overweight and Obese Children
Development and Evaluation of a Web-based Parental Role Modeling Program for Childhood Obesity Management
The goal of this clinical trial is to learn whether an online family health education program can help Vietnamese children aged 7-9 years with overweight or obesity develop healthier habits.
- Conditions
- Childhood Obesity, Overweight and Obese Children, Pediatric Obesity, Overweight and Obesity in Schoolchildren
- Trial name
- NCT07641452
- Testing
- Web-based parental role modeling program, Standard health education materials
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Do Thi Thu Huyen
Diabetic Retinopathy (DR)
Using Implementation Science to Adapt a Targeted Transportation Intervention for Patients With Diabetic Retinopathy (PRONTO-EYE)
This is a a type 3 hybrid effectiveness-implementation pilot study to evaluate the PRONTO-EYE intervention, a rideshare transportation program, in patients with diabetic retinopathy with Medicaid insurance on adherence to…
- Trial name
- PRONTO-EYE (NCT07296952)
- Testing
- PRONTO-EYE
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Arteriovenous Fistula, Arteriovenous Graft
Access Creation for Hemodialysis: Association With Structural Changes of the Heart
The purpose of this study is to determine if the creation of a fistula or a graft plays a role in the development of heart disease for patients undergoing hemodialysis
- Conditions
- Arteriovenous Fistula, Arteriovenous Graft, Left Ventricular Hypertrophy, Brain Natriuretic Peptide
- Trial name
- NCT00368147
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Kidney Disease
Behavioral Intervention and Adherence in Dialysis
The aim of the proposed work is to conduct a randomized controlled trial (RCT) evaluation of a behavior change intervention designed to enhance fluid-intake adherence (compliance) among hemodialysis patients.
- Trial name
- NCT01066949
- Testing
- Behavioral self mangement, Support and discussion
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- University of Iowa
Implant Site Reaction
Effect of Static Magnetic Field on Dental Implant Stability.
To evaluate the effect of static magnetic field on dental implant to bone integration.
- Trial name
- NCT06226038
- Testing
- Magnet disc, Stainless steel
- Where
- Thailand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Neuromuscular Diseases, Sarcopenia
Soft-robotic Glove Support of High-demand Tasks
The hand is important to perform activities of daily living (ADL). However, many people experience a loss of hand function as result of a traumatic brain injury, spinal cord injury, stroke or orthopedic problems, or due to…
- Trial name
- NCT05318638
- Testing
- Soft robotic glove
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Roessingh Research and Development
Dietary Change, Obesity & Overweight
Dietary Peanuts and Nutrition-Related Outcomes
This study will look at how eating peanuts every day might affect participants weight, how healthy their diet is, and how they feel when eating.
- Conditions
- Dietary Change, Obesity & Overweight, Food Acceptance
- Trial name
- NCT07244458
- Testing
- Peanuts, Dual-energy X-ray absorptiometry (DEXA) scans
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ian J. Neeland, MD
Depression
The Early Medication Change (EMC) Trial
The EMC trial investigates for the first time prospectively whether Major Depression Disorder patients with non-improvement after 14 days of antidepressive treatment with EMC are more likely to become remitters compared to…
- Trial name
- EMC (NCT00974155)
- Testing
- Escitalopram, venlafaxine, lithium, Escitalopram, venlafaxine
- Where
- Germany
- Volunteers
- 889 people
- Sponsor
- K. Lieb
Autism Spectrum Disorder
Gaze Modification Strategies for Toddlers With Autism Spectrum Disorder
This project seeks to understand how the gaze behavior of infants and children with or at high risk for autism spectrum disorder (ASD) may be manipulated in the contexts of dynamic social and non-social scenes.
- Trial name
- ASD (NCT02488226)
- Testing
- Gaze-contingent eye-tracking technology
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Yale University
Relapsing-remitting Multiple Sclerosis
A Proof-of-Concept Study to Correlate Retinal Nerve Fiber Layer Changes in Patients With Multiple Sclerosis Treated With Natalizumab or Interferon Beta 1-a
Phase IV, proof-of-concept, randomized, open-label, multi-center, two-arm, 9-month study to evaluate the neuroprotective effects of Natalizumab (TYSABRI®) or Interferon beta-1a (AVONEX®) treatments initiated at the time of…
- Trial name
- PRTOECT (NCT00771043)
- Testing
- TYSABRI and AVONEX
- Sponsor
- Biogen
Stage II Rectal Cancer, Stage III Rectal Cancer
Quicksilver II Pilot Study
This pilot study is being done to answer the following question: Will patients with margin-clear Stage 2 or 3 rectal cancer who don't require a colostomy agree to be randomized to 'surgery only' or 'chemotherapy and then…
- Trial name
- NCT07688135
- Testing
- Direct-to-surgery (i.e., no neoadjuvant chemotherapy), Control Group
- Volunteers
- 18 people
- Sponsor
- Mount Sinai Hospital, Canada
Obesity, Overweight
A Study to Investigate the Efficacy and Safety of Elecoglipron in Asian Participants With Obesity or Overweight With or Without Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy and safety of elecoglipron compared with placebo adjunct to diet and exercise for weight management, in adult participants living with obesity or overweight with or without…
- Trial name
- Elecoglipron (NCT07775404)
- Testing
- Elecoglipron
- Where
- 49 sites in China, Hong Kong and 3 more
- Volunteers
- 351 people
- Sponsor
- AstraZeneca
Oncology
PEWS Implementation in an LMIC Setting
The PEWS implementation study will be undertaken with the following objectives: 1. Assess the effectiveness of implementation of PEWS and resuscitation training to identify patients at risk for clinical deterioration and to…
- Trial name
- PEWSPAL (NCT04180306)
- Testing
- pediatric early warning scoring system and resuscitation curriculum
- Where
- 2 sites in Palestinian Territories
- Volunteers
- 1,850 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Autism Spectrum Disorder, Restricted Behavior
Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth
The purpose of this open label trial is to examine the preliminary feasibility, acceptability, and effectiveness of a 12-week behavioral intervention program (1 hour/week) to treat insistence on sameness (e.g., difficulty…
- Conditions
- Autism Spectrum Disorder, Restricted Behavior, Autism
- Trial name
- M-PRT-IS (NCT06362733)
- Testing
- Modified Pivotal Response Treatment for Insistence on Sameness in Autistic Youth
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Stanford University
Borderline Intellectual Functioning (BIF)
A Comparative Study of Virtual Reality and Sensory-Adapted Dental Environments for Dental Anxiety Reduction in Individuals With Borderline Intellectual Functioning
A randomized clinical trial was conducted with 100 participants with borderline intellectual functioning (BIF) and moderate dental anxiety (DAS: 9-12).
- Trial name
- NCT07503249
- Testing
- immersive VR software delivered through Meta Quest 3® headset during dental procedure, Sensory adapted dentist environment
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Oasi Research Institute-IRCCS
Behavior, Child, Cognitive Change
Effects of Lemon Verbena Extract Supplementation in Sub-ADHD Children
The aim of this study is to investigate the effects of 15 mg/kg lemon verbena, in comparison to placebo, on the attention deficit hyperactivity disorder (ADHD) type behaviour and cognitive function of children who do not have a…
- Trial name
- NCT05476549
- Testing
- Lemon verbena
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Northumbria University
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