Clinical trials: Monochorionic Diamniotic Placenta
Monochorionic Twins
Unequal Placental Sharing in Monochorionic Diamniotic Twins: an Observational Study
This is an observational study in 3 cohorts of monochorionic diamniotic (MCDA) twins. The aim of the study is to assess whether unequal placental sharing can be predicted in pregnancy and whether it is predictive of pregnancy…
- Trial name
- TWINSHARE (NCT03024918)
- Where
- Belgium
- Volunteers
- 393 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Twin; Pregnancy, Affecting Fetus or Newborn, Fetal Growth Retardation
Selective Fetal Growth Restriction in Monochorionic Twins - an International Investigation
Optimal diagnostic management and underlying pathophysiological mechanisms of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies have not been fully clarified.
- Conditions
- Twin; Pregnancy, Affecting Fetus or Newborn, Fetal Growth Retardation, Twin Monochorionic Diamniotic Placenta, Twin Diseases
- Trial name
- CONTRAST (NCT05952583)
- Testing
- Ultrasound
- Where
- 6 sites in United States, Belgium and 4 more
- Volunteers
- 274 people
- Sponsor
- Leiden University Medical Center
Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta
Database of Monochorionic Pregnancies
The purpose of this study is to collect and analyze data regarding natural history, indications for fetal interventions, and maternal and fetal/neonatal outcomes associated with complicated monochorionic twin pregnancy.
- Conditions
- Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta, Twin; Complicating Pregnancy, Twin to Twin Transfusion Syndrome
- Trial name
- NCT05543499
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Miami
Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China
Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China (ChiTwiMC) is supported by National Key Research and Development Program of China - Reproductive Health and Women's and Children's Health Protection…
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Twin to Twin Transfusion as Antepartum Condition, Pre-Term, Pre-Eclampsia
- Trial name
- ChiTwiMC (NCT06414655)
- Where
- 11 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Twin Monochorionic Diamniotic Placenta
Safety and Efficacy of Fetoscopes Used in Fetoscopic Selective Laser Photocoagulation
The purpose of this study is to evaluate the safety and efficacy of the investigational fetoscopes used in patients undergoing fetoscopic selective laser photocoagulation for complicated monochorionic-diamniotic pregnancies.
- Trial name
- NCT06022510
- Testing
- Fetoscopy Sets for Anterior and Posterior Placentas
- Where
- United States
- Sponsor
- Michael A Belfort
Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta
Austrian Registry on the Outcome of Monochorionic Pregnancies
About one third of twin pregnancies are resulting from a single fertilized oocyte. Two third of these monozygotic twins share a common placenta and are therefore called monochorionic.
- Conditions
- Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta, Twin-To-Twin Transfusion Syndrome, Twin Pregnancy With Antenatal Problem
- Trial name
- MonoReg (NCT03171909)
- Where
- 13 sites in Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Preterm Birth, Preterm Labor
Is the Vaginal Microbiome and Metabolome Associated With Spontaneous Preterm Birth (sPTB) in Multiple Pregnancies?
The aim of this study is to try and find links between the microscopic organisms (such as bacteria, yeasts and viruses) in the vagina, and twin pregnancies that deliver too early (preterm birth).
- Conditions
- Preterm Birth, Preterm Labor, Multiple; Pregnancy, Complicated, Twin Dichorionic Diamniotic Placenta
- Trial name
- SPRUCE (NCT06053697)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta
MoDi Twin Placental Imaging
Twin-twin transfusion syndrome (TTTS) can arise in monochorionic, diamniotic (MoDi), those identical twins arising from division of a single fertilized ovum at 4-8 days gestational age (GA) or monochorionic, monoamniotic (MoMo or…
- Conditions
- Monochorionic Diamniotic Placenta, Monochorial Monoamniotic Placenta, Monochorionic Twins, Ultrasound Doppler
- Trial name
- NCT07667647
- Testing
- Verasonics Vantage 256 Ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Carilion Clinic
Prenatal Disorder, Premature Birth
Develop a Multi-disciplinary Approach for a Personalized Prenatal Diagnostics and Care for Twin Pregnancies
Different screening modalities evaluation to develop algorithms to predict pregnancy complications in twin pregnancies, and evaluation of serologic response to BNT162b2 Pfeizer/BioNTech vaccination.
- Conditions
- Prenatal Disorder, Premature Birth, Twin Pregnancy With Antenatal Problem, Twin; Pregnancy, Affecting Fetus or Newborn
- Trial name
- PRETWINSCREN (NCT04595214)
- Testing
- TTTS cases are treated by intra-uterine laser for separation.
- Where
- 7 sites in Belgium, Canada and 4 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Twin to Twin Transfusion as Antepartum Condition, Monochorionic Diamniotic Placenta
Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome
The purpose of this study is to evaluate the use of diode laser photocoagulation of the communicating vessels in twin-to- twin transfusion syndrome (TTTS) with respect to maternal, fetal and neonatal outcomes.
- Trial name
- NCT05008744
- Testing
- Fetoscopic laser ablation
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Seattle Children's Hospital