Clinical trials: Monocytes
Diabetes Mellitus
Association Between Uric Acid / High Density Lipoprotein Ratio and Monocyte / High Density Lipoprotein Ratio With Diabetic Complications
Type 2 diabetes mellitus (T2DM) poses a formidable global health challenge, with complications arising in both the microvascular and macrovascular domains as glycemic control worsens.the aim of the study to evaluate uric acid /…
- Trial name
- NCT06754813
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis
Novel Immune Markers in Patients With Multiple Sclerosis
The investigators hypothesize that the endogenous cannabinoid signalling system has lost homeostasis in the disease multiple sclerosis (MS).
- Trial name
- NIMMS (NCT01026272)
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
Gram Positive Infection
Effect of Linezolid on Ex Vivo Neutrophil and Monocyte Function in Healthy Males
Results from previous studies have been inconclusive and the effect of linezolid on cytokines remains unclear. This study is designed to evaluate the effect of linezolid on the functionality of white blood cells (neutrophils and…
- Trial name
- NCT01544673
- Testing
- linezolid
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Sepsis
Algorithm for Predicting the Unfavorable Course of Sepsis in Children
A comprehensive strategy will be used to investigate the relationship and correlation between 4 diagnostically significant markers relevant for early diagnosis and prediction of complications and death in the development of…
- Trial name
- NCT05908162
- Testing
- Bood leukocyte subsets
- Where
- Belarus
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Cystic Fibrosis
Monocytes as Predictors of Cystic Fibrosis-related Bone Disease
Hypothesis: Circulating monocytes RANK and MCSF-R expression is predictive of Cystic Fibrosis-related Bone Disease. Study design: Single-center comparative cross-sectional study Population: Patients with a CFTR channel mutation…
- Trial name
- MucOs (NCT04877223)
- Testing
- No intervention
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Université de Reims Champagne-Ardenne
Sepsis, Endotoxemia, Immunosuppression
The Effects of Human Endotoxemia on Functional Capacity of Hematopoietic Stem and Progenitor Cells
We will investigate whether human endotoxemia induces changes in human bone marrow cells and their downstream effector cells. To comprehensively investigate underlying mechanisms behind functional and transcriptional changes in…
- Trial name
- LPS-BM (NCT05570643)
- Testing
- LPS
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
HIV Infections
Peripheral Reservoir of HIV DNA in Monocytes Pivotal to Cognition in HIV
Sixty HIV participants will be enrolled and stratified by PBMC HIV DNA levels, either high (greater than or equal to 5000 copies/106 cells) or low (less than 5000 copies/106 cells).
- Trial name
- NCT00782808
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- SEARCH Research Foundation
Abdominal Aortic Aneurysm, Coronary Artery Disease
White Blood Cell Counts and Onset of Cardiovascular Diseases: a CALIBER Study
The complete blood count is a commonly performed blood test, and previous small studies have suggested that the counts of some types of white blood cell in the complete blood count may be related to the onset of cardiovascular…
- Conditions
- Abdominal Aortic Aneurysm, Coronary Artery Disease, Stroke, Heart Failure
- Trial name
- CALIBER (NCT02014610)
- Volunteers
- 800,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Cardiovascular Risk Markers, Chronic Periodontitis
Non-surgical Peridontal Treatment on Cardiovascular Risk Markers
The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases
- Trial name
- NCT04540328
- Testing
- Non-surgical periodontal treatment
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Sepsis, Intensive Care (ICU)
Investigation of the Relationship Between MD, MLR and NLR With APRs in Sepsis in the ICU
The aim of this study is to investigate, in patients admitted to the intensive care unit either for reasons other than sepsis who subsequently develop sepsis or with a primary diagnosis of sepsis, whether monocyte distribution…
- Conditions
- Sepsis, Intensive Care (ICU), Acute Phase Biomarkers
- Trial name
- NCT07537179
- Testing
- Monocyte Distribution
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oguz Gundogdu
Sepsis Syndrome
Metabolism of Branched-chain Amino Acids in Monocyte/Macrophage During Sepsis
The current project was designed to examine the metabolic level of branched-chain amino acids in plasm and monocyte/macrophage, and its role in immune dysfunction during sepsis.
- Trial name
- NCT03842371
- Testing
- Metabolic level of BCAAs in monocytes and macrophages
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Diabetes Mellitus, Type 2, Atherosclerosis
The Gene Expression Patterns in the Peripheral White Blood Cells of Type 2 Diabetic Patients
The investigators hypothesize that macrophages play a crucial role in the pathogenesis of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT00155922
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Inflammation
Suppression of Postprandial Monocyte Activation by Blueberries or Docosahexaenoic Acid in Humans
The overall goal of the research study is to determine whether a high-fat meal causes postprandial (after meal) inflammation, and whether eating n-3 polyunsaturated fatty acids (PUFAs) or blueberries that are rich in…
- Trial name
- NCT02472171
- Testing
- High saturated fat meal, blueberry powder and sunflower oil
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Yellow Fever
Turnover of Antigen Specific Lymphocytes and Monocytes After Immunization With the 17D Yellow Fever Vaccine
The yellow fever vaccine is a live, attenuated virus that results in a robust immune response, especially in the T cell compartment.
- Trial name
- NCT01290055
- Testing
- Yellow fever vaccine, Deuterium (70% enriched 2H2O) labeled water
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Sri Edupuganti
Healthy, HIV Infection
Immune Responses to HIV in Blood Cells in HIV-Infected and HIV-Uninfected Volunteers
This study will explore the responses of the immune system to infection with HIV and other pathogens and the changes in these responses over time.
- Trial name
- NCT00027482
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Obstructive Pulmonary Disease
Apoptotic Cell (AC) Uptake by Human Alveolar Macrophages (AM)
The purpose of this study is to compare the ability of two types of white blood cells to eat dead host cells, and how this process affects their ability to protect the body from infection.
- Trial name
- NCT01099410
- Testing
- Fiberoptic bronchoscopy, blood draw, intravenous catheter
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Atrial Fibrillation, Arrhythmia
Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls
The study will analyze blood from volunteers to determine whether there is an underlying epigenetic cause of the inflammation of the heart associated with atrial fibrillation (AF) and its progression with age.
- Trial name
- NCT04766814
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tulane University
Sepsis, Severe Infection
Evaluation of Monocyte Volume Distribution Width (MDW) for Early Detection of Sepsis
The measurement of monocyte volume width distribution (MDW) is intended for use with adult patients presenting to the emergency department (ED), where a CBC with Differential has been ordered, as an aid in the early detection of…
- Trial name
- MDW (NCT03145428)
- Testing
- CBC-Diff Monocyte volume width distribution (MDW)
- Where
- 3 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beckman Coulter, Inc.
Erectile Dysfunction, Inflammation
Effects of Tadalafil on LMR and MHR in Patients With ED
The aim of the study was to investigate whether daily 5 mg tadalafil over eight weeks affects to Lymphocyte/Monocyte ratio (LMR) and Monocyte/High-Density Lipoprotein ratio (MHR) in patients with erectile dysfunction (ED).
- Trial name
- NCT03918993
- Testing
- Tadalafil 5mg tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Samsun Liv Hospital
Atherosclerosis
Characterizing PAI-1 Modulation on Monocyte Adhesion
To determine how altering the expression of a gene known as PAI-1 may affect the adhesive capacity of cells that play a critical role in the developement of human atherosclerosis.
- Trial name
- NCT00512031
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University