Clinical trials: Monocytes
Advanced Cancer, Healthy
Laboratory Testing for Tie-2 Expressing Monocytes (TEMs) in Blood
Tie-2 expressing monocytes (TEMs) are a specific type of blood cell that are present in healthy individuals and in people with cancer.
- Trial name
- NCT01543841
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Exercise Training
Effect of Aronia Supplementation on the LPS-CD14-TLR2/4 Axis in Football Players
This randomized, double-blind, placebo-controlled trial will investigate the effects of 8-week Aronia melanocarpa supplementation on exercise-induced activation of the LPS-LBP-CD14-TLR2/TLR4 axis in trained male football players.
- Trial name
- ARONIA-TLR (NCT07829523)
- Testing
- Aronia melanocarpa Extract
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hanna Dziewiecka
Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
Endothelial Dysfunction, Monocyte Activation, and Vasculopathy in Patients With Obstructive Sleep Apnea (OSA) and Effect of 6-month CPAP Treatment
This purpose of this study is to 1. Determine the change in endothelial dependent vascular reactivity and vascular properties 2. Determine the changes in monocytes activation 3. Determine the change in pro-inflammatory status 4.
- Conditions
- Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Endothelium, Inflammation
- Trial name
- NCT01312168
- Testing
- Therapeutic CPAP, Subtherapeutic CPAP
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Atherosclerosis
A Human In Vivo Feeding Study Of The Blood Monocyte Response To Dietary Lipid Intake
The aim of the present study is to identify the effects of different dietary fats on the body's immune system and how different types of cells respond.
- Trial name
- Lipophage14 (NCT02101346)
- Testing
- Mixed High Fat Diet, Saturated fat diet, Monounsaturated fat diet
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Pregnancy, Infections in, Covid19
Perinatal Outcomes and Hematologic Parameters in COVID-19 Pregnancies
Complete blood count parameters are routinely evaluated cost-effective markers in diagnosis and clinical follow-up of infectious diseases.There is increasing number of studies to report the course of COVID-19 in pregnancy.
- Trial name
- NCT04515108
- Testing
- Clinical assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Gram Positive Infection
Effect of Linezolid on Ex Vivo Neutrophil and Monocyte Function in Healthy Males
Results from previous studies have been inconclusive and the effect of linezolid on cytokines remains unclear. This study is designed to evaluate the effect of linezolid on the functionality of white blood cells (neutrophils and…
- Trial name
- NCT01544673
- Testing
- linezolid
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Atherosclerosis
Monocyte Activation in Preclinical Atherosclerosis
The study of proinflammatory and anti-inflammatory cytokines and chemokines expression profiles in human monocytes to identify new effective biomarkers that have the best diagnostic potential in asymptomatic atherosclerosis.
- Trial name
- MAPA (NCT02126280)
- Testing
- In vitro estimation of individual reactivity of monocytes
- Where
- Russia
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Institute for Atherosclerosis Research, Russia
Thyroid Cancer
Myeloid Cell Reprogramming in Thyroid Carcinoma
This study investigates the reprogramming of myeloid cells in patients with thyroid carcinoma. The investigators hypothesize that tumor-derived factors change the function of myeloid cells (peripheral blood and bone…
- Trial name
- NCT03397238
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Aggressive Periodontitis
Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein-1
The aim of this study is to estimate GCF MCP-1 levels of healthy and Aggressive periodontitis (AgP) subjects and to compare MCP-1 levels between Localized AgP (LAgP) and Generalized AgP (GAgP) to establish its predictive…
- Trial name
- MCP-1 (NCT02927704)
- Testing
- Gingival crevicular fluid (GCF) sample
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Atherosclerosis
Macrophage Polarization in Response to Macronutrient Intake in Healthy Humans: A Randomized Clinical Study
Macrophages can exhibit distinct phenotypes and functions in response to stimuli and can polarize into one of three distinct phenotypes: a pro-inflammatory (M1), an anti-inflammatory pro-tissue (M2) and metabolically-activated…
- Trial name
- NCT03173677
- Testing
- Lipid Intake, Glucose intake, Protein intake
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Saud Bin Abdulaziz University for Health Sciences
Immune System, Nutrition
Postprandial Monocyte Study
The purpose of this research is to determine the role of a type of immune cell in blood, called a non-classical monocytes (NCMs), following consumption of a high-fat meal.
- Conditions
- Immune System, Nutrition, Inflammation
- Trial name
- PPMS (NCT05792137)
- Testing
- High saturated fat challenge meal, High mono unsaturated fat challenge meal
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
COPD, Emphysema
Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)
The aim of this study is to investigate the mechanisms whereby leukocytes are recruited to the lung in chronic obstructive pulmonary disease (COPD) and cause tissue destruction.
- Conditions
- COPD, Emphysema, Chronic Bronchitis
- Trial name
- NCT00147082
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Multiple Sclerosis
Novel Immune Markers in Patients With Multiple Sclerosis
The investigators hypothesize that the endogenous cannabinoid signalling system has lost homeostasis in the disease multiple sclerosis (MS).
- Trial name
- NIMMS (NCT01026272)
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
Atherosclerosis
Characterizing PAI-1 Modulation on Monocyte Adhesion
To determine how altering the expression of a gene known as PAI-1 may affect the adhesive capacity of cells that play a critical role in the developement of human atherosclerosis.
- Trial name
- NCT00512031
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Venous Thromboembolism, Pulmonary Embolism
IgG Dependent Monocyte Activation in Proximal Venous Thromboembolism
The primary objective of this study is to search for, in vitro, elements associated with IgG-dependent monocyte activation (signaling pathway activation, expression of pro-coagulant and pro-inflammatory factors) and to describe…
- Trial name
- ActiMon (NCT02713581)
- Testing
- Blood sampling
- Where
- 2 sites in France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Healthy
Pizza Meal Challenge and Immunometabolism (PIMETA)
High salt intake is a major risk factor for cardiovascular events, including stroke, heart disease and kidney failure. Pizza is a popular salty food.
- Trial name
- PIMETA (NCT04175249)
- Testing
- Pizza meal challenge
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Age-Related Macular Degeneration
Genetic Study of Age-Related Macular Degeneration
This study will examine skin and blood cells for genetic changes related to the development of age-related macular degeneration, an eye disease that can significantly impair the ability to read, drive, and carry out daily…
- Trial name
- NCT00357578
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Inflammation
Strength Training Induced Alterations in Markers of Immune Function
Exercise has been used to help prevent or slow the progression of inflammation-related disease; however, the mechanism by which this activity may lower concentrations of inflammatory markers remains unclear.
- Trial name
- NCT01450852
- Testing
- Strength Training
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Atherosclerosis
Leucine, mTOR and Athero
High protein low carbohydrate diets have become popular in recent years to help facilitate weight loss. It is controversial if these diets are associated with an increased risk of cardiovascular disease.
- Trial name
- HPL (NCT05470218)
- Testing
- Meal
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Healthy, HIV Infection
Immune Responses to HIV in Blood Cells in HIV-Infected and HIV-Uninfected Volunteers
This study will explore the responses of the immune system to infection with HIV and other pathogens and the changes in these responses over time.
- Trial name
- NCT00027482
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)