Clinical trials: Monocytes
Enhanced Recovery After Thoracic Surgery Protocol, C-reactive Protein
Enhanced Recovery After Thoracic Surgery
Despite significant advances in perioperative care, major complications continue to be seen in patients undergoing major surgery.
- Conditions
- Enhanced Recovery After Thoracic Surgery Protocol, C-reactive Protein, White Blood Cell Count, Neutrophil/Lymphocyte Ratio
- Trial name
- NCT05329311
- Testing
- ERATS protocol applied, ERATS protocol not applied
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
HIV Dementia
Modulation of Monocyte Activation by Atorvastatin in HIV Infection
Activated monocytes play a key role in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Individuals with HAND have expanded populations of activated monocytes.
- Trial name
- NCT01263938
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Obesity, Metabolic Syndrome
The Monocyte Subsets in Obese Patients With and Without Metabolic Syndrome
Obesity is associated with a chronic low-grade inflammation characterized by macrophage infiltration in adipose tissue that induces insulin resistance and the appearance of metabolic syndrome (MS).
- Trial name
- NCT03241394
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ioannina
Psoriatic Arthritis
Monocyte Chemoattractant Protein-1 in Psoriatic Arthritis Patients
1. Evaluate serum levels of (MCP-1) in PsA with or without cardiovascular affaction . 2. Detect subclinical cardiovascular affaction in patients with PsA for early diagnosis and management .
- Trial name
- NCT05637905
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Assiut University
Childhood Acute Basophilic Leukemia, Childhood Acute Eosinophilic Leukemia
Biomarkers in Bone Marrow Samples From Pediatric Patients With High-Risk Acute Myeloid Leukemia
This pilot research trial studies biomarkers in bone marrow samples from pediatric patients with high risk acute myeloid leukemia.
- Conditions
- Childhood Acute Basophilic Leukemia, Childhood Acute Eosinophilic Leukemia, Childhood Acute Erythroleukemia (M6), Childhood Acute Megakaryocytic Leukemia (M7)
- Trial name
- NCT01076569
- Testing
- laboratory biomarker analysis
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Children's Oncology Group
Immune System
Evaluation of Monocyte Expression of HLA-DR (mHLA-DR) in Geriatric Service
The acceleration of population aging and the improved management of comorbidities lead to an increase in the number of multi-pathological elderly patients admitted to geriatric services.
- Trial name
- SENIOR HLA DR (NCT06513520)
- Testing
- Blood sampling
- Where
- 2 sites in France
- Volunteers
- 81 people
- Sponsor
- Hospices Civils de Lyon
Psoriasis
TL1A Expression in Psoriatic Skin
TL1A is a newly discovered signal molecule that may be crucially involved in the maintenance of chronic inflammatory disorders. TL1A has also been demonstrated in psoriatic skin but the importance of TL1A in psoriasis is still…
- Trial name
- NCT01744327
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia
This phase II trial is studying the side effects and best dose of bortezomib and to see how well it works when given together with combination chemotherapy in treating younger patients with recurrent, refractory, or secondary…
- Conditions
- Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b), Adult Acute Myeloblastic Leukemia With Maturation (M2), Adult Acute Myeloblastic Leukemia Without Maturation (M1)
- Trial name
- NCT00666588
- Testing
- idarubicin, cytarabine, bortezomib
- Where
- 82 sites in United States, Australia and 1 more
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2
CPX-351 Versus Immediate Stem Cell Transplantation for the Treatment of High-Grade Myeloid Cancers With Measurable Residual Disease
This phase II trial studies the effect of CPX-351 followed by donor stem cell transplantation versus immediate donor stem cell transplantation in treating patients with high-grade myeloid cancers with measurable residual disease.
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndrome With Excess Blasts-2, Myeloid Neoplasm
- Trial name
- NCT04526288
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Liposome-encapsulated Daunorubicin-Cytarabine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Fred Hutchinson Cancer Center
Leukemia
A Phase I/II Study of Induction Chemotherapy With Daunorubicin, Cytarabine, Topotecan and Etoposide
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00005793
- Testing
- Cytarabine, Daunorubicin, Etoposide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Oral Squamous Cell Carcinoma (OSCC), Premalignant Lesion
Comparison of TLC (Total Leucocyte Count), Neutrophils and Monocytes in Oral Squamous Cell Carcinoma and Pre-malignant Disorders
Oral squamous cell carcinoma is one of the significant public health concerns and the most prevalent malignancies affecting the head and neck region globally.
- Trial name
- NCT07899255
- Testing
- CBC will be required to assess the level of TLC (Total Leucocyte Count), Neutrophils and Monocytes in patient of oral squamous cell carcinoma and oral pre malignant conditions, using different stains
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Dow University of Health Sciences
Drug-induced Disorder of Liver, Adverse Reaction to Drug
Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity
Drug metabolism in the liver is subject to large fluctuations (differences between women and men, people of different ethnic backgrounds, children and adults).
- Trial name
- NCT02353455
- Testing
- Blood sampling
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Andreas Benesic, MD
Acute Ischemic Stroke
Phase I Clinical Safety Study About Human Umbilical Cord Blood Monocyte in the Acute Ischemic Stroke
The objective of the study is to determine the safely of Human Umbilical Cord Blood mononuclear cells by Intravenous injection in acute ischemic stroke patients.
- Trial name
- NCT02433509
- Testing
- hUCB
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- China Medical University Hospital
Sepsis, Septic Shock
Esomeprazole to Reduce Organ Failure in Sepsis
Sepsis is a severe disease with a high mortality rate and lack of efficacious therapies. Proton pump inhibitors (PPI) are drugs widely used to inhibit acid secretion by gastric cells and with a high safety profile.
- Trial name
- PPI-SEPSIS (NCT03452865)
- Testing
- Esomeprazole
- Where
- 17 sites in Italy, Kazakhstan and 1 more
- Volunteers
- 300 people
- Sponsor
- Università Vita-Salute San Raffaele
Acute Coronary Syndrome
GALNT4 in Patients With Acute Coronary Syndrome
The expression of GALNT4 in blood with acute coronary syndrome
- Trial name
- NCT03335514
- Testing
- expression of GALNT4
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Acute Kidney Injury
Real-time Early Detection of Nephrotoxicity by Urinary Biomarker Analysis With SeroFlow Technology
The study aims to perform real-time validation of the RenaFAST kit (a point-of-care test kit that quantifies three urinary proteins) in predicting acute kidney injury(AKI) among patients prescribed drug therapies of nephrotoxic…
- Trial name
- RenaFAST (NCT06124885)
- Testing
- AKI risk screening using RenaFAST POCT test kits
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
Clofarabine, Cytarabine, and Filgrastim Followed by Infusion of Non-HLA Matched Ex Vivo Expanded Cord Blood Progenitors in Treating Patients With Acute Myeloid Leukemia
This phase I trial is studying the safety and potential efficacy of infusing non-human leukocyte antigen (HLA) matched ex vivo expanded cord blood progenitors following treatment with clofarabine and cytarabine for patients with…
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT01031368
- Testing
- cytarabine, clofarabine, filgrastim
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Nohla Therapeutics, Inc.
Leukemia, Myelodysplastic Syndromes
Busulfan and Cyclophosphamide Followed by Bone Marrow Transplantation in Treating Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with donor bone marrow transplantation may allow the doctor to give higher doses of…
- Conditions
- Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
- Trial name
- NCT00004896
- Testing
- busulfan, cyclophosphamide, allogeneic bone marrow transplantation
- Where
- United States
- Sponsor
- Northwestern University
Leukemia
S0301 Cyclosporine, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy, such as cyclosporine, daunorubicin, and cytarabine, use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00066794
- Testing
- filgrastim, sargramostim, cyclosporine
- Where
- 97 sites in United States
- Volunteers
- 69 people
- Sponsor
- SWOG Cancer Research Network
Leukemia
Pilot Trial of a WT-1 Analog Peptide Vaccine in Patients With Myeloid Neoplasms
The purpose of this study is to determine whether the WT-1 vaccine causes an immune response and is safe. The WT-1 vaccine is made up of protein pieces that the patient's immune system can recognize as abnormal.
- Trial name
- NCT00665002
- Testing
- WT-1, Montanide, Sargramostim (GM-CSF)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute