Clinical trials: Monogenic Obesity
Monogenic Obesity
A Study Evaluating Mibavademab Treatment of Obesity Due to Leptin (LEP) Gene Mutations in Children, Adolescents and Adults
This study is researching an experimental drug called mibavademab. The study is focused on patients with a condition called monogenic obesity.
- Trial name
- NCT07220772
- Testing
- Mibavademab
- Where
- 3 sites in Germany, Turkey (Türkiye)
- Volunteers
- 4 people
- Sponsor
- Regeneron Pharmaceuticals
Monogenic Obesity
Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity
Obesity is a frequent disease mainly caused by environmental/polygenic factors and more rarely caused by the alteration of a single gene ("monogenic obesity").
- Trial name
- OBEGENE (NCT05362565)
- Testing
- Salivary Sampling
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Monogenic Obesity
A Multicenter Pharmacoepidemiological Cohort on Real Life Use of Semaglutide in Adolescents or Adults With Monogenic Obesity
Rare genetic forms of obesity, so called monogenic obesity are linked to alteration in energy balance involving hypothalamic pathways.
- Trial name
- ObGeSema (NCT06380426)
- Where
- 2 sites in France
- Volunteers
- 175 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Genetic Obesity
International Genetic Obesity Registry
Genetic obesity results from changes in specific genes that affect appetite regulation, metabolism, and fat storage. Its severity and associated health issues vary depending on the genetic cause.
- Trial name
- iGO Registry (NCT07296900)
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- University of Ulm
Monogenic Obesity
Efficacy of Semaglutide s.c. Once-weekly on Weight Loss and Management in Adolescents With Monogenic Obesity in Clinical Practice
This observational study aims to assess the effect of once-weekly s.c. semaglutide 2.4 mg as an adjunct to a calorie-reduced diet and increased physical activity on weight loss, change in hunger, body composition, depression, and…
- Trial name
- NCT07302802
- Testing
- Semaglutide (administered by PDS290 pen-injector)
- Where
- 7 sites in France, Germany and 3 more
- Volunteers
- 70 people
- Sponsor
- Prof. Dr. Martin Wabitsch
Bariatric Surgery Candidate
Abu Dhabi Diabetes and Obesity Study -2 Bariatric
Study on outcomes on bariatric surgery, particularly in terms of metabolic parameters in the UAE is scant. Also Genetic data from this population is limited and hence a study on genetic determinants of response to bariatric…
- Trial name
- ADOS-2B (NCT05140798)
- Where
- United Arab Emirates
- Volunteers
- 1,200 people
- Sponsor
- Imperial College London Diabetes Centre
Monogenic Obesity, Non Syndromic Obesity
Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity (GENOBE)
Non-syndromic monogenic obesity is a group of rare diseases characterized by severe and early onset obesity. Genetic characterization of these rare forms is important to target patients who may benefit from a personnalized care…
- Trial name
- GENOBE (NCT06113523)
- Testing
- monogenic obesity
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Lipodystrophy, Generalized Lipodystrophy (GLD)
Compassionate Use or Expanded Access of Mibavademab
Provide Expanded Access to REGN4461 for patients with diseases associated with deficient leptin signaling.
- Conditions
- Lipodystrophy, Generalized Lipodystrophy (GLD), Monogenic Obesity (MOB)
- Trial name
- NCT04710056
- Testing
- REGN4461
- Sponsor
- Regeneron Pharmaceuticals