Clinical trials: Mood Change
Mood Lability, PTSD
FamilyLive Feasibility and Effectiveness Study
Children who have been exposed to trauma (defined as physical, sexual or emotional abuse, neglect, exposure to life threatening events, domestic and community violence, parental mental health disorders, substance abuse, and/or…
- Conditions
- Mood Lability, PTSD, Anxiety
- Trial name
- NCT01524185
- Testing
- FamilyLive, Standard Mental Health Treatment
- Where
- United States
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Depressive Disorder, Anxiety Disorders
Research of Unified Protocol for the Treatment of Common Mental Disorders in Adolescents in Hong Kong
The Unified Protocol (UP) is an emotion-focused, cognitive-behavioural intervention that is developed to target core temperamental characteristics underlying anxiety and depressive disorders.
- Trial name
- NCT04091139
- Testing
- Unified protocol for adolescents (UP-A), Treatment as usual (TAU)
- Where
- Hong Kong
- Volunteers
- 27 people
- Sponsor
- Chinese University of Hong Kong
Microbiome, Glucose Metabolism
Westlake Sailing Cohort
Little is known about the dynamic change of human microbiome in different body sites including skin, mouth and gut during sailing.
- Conditions
- Microbiome, Glucose Metabolism, Mood, Environment
- Trial name
- NCT04611945
- Where
- China
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Westlake University
Schizophreniform Disorder, Bipolar I Disorder
Prevention of Weight Gain in Early Psychoses
The purpose of this study is to determine whether individuals with psychotic spectrum disorders ( Schizophrenia, Schizoaffective disorder,Schizophreniform Disorder, Bipolar Disorder (Type I),Bipolar Disorder (Type II),Major…
- Conditions
- Schizophreniform Disorder, Bipolar I Disorder, Bipolar II Disorder, Major Depressive Disorder
- Trial name
- NCT01075295
- Testing
- Behavioural Intervention for the Prevention of Weight Gain, TAU
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Prediction of Antidepressant Treatment Response Using Machine Learning Classification Analysis
Despite significant advances in pharmacological treatment, the global burden of depression is increasing worldwide. The major challenge in antidepressant treatment is the clinicians' inability to predict the variability in…
- Trial name
- NCT02330679
- Testing
- Desvenlafaxine
- Where
- 2 sites in Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Depression, Obesity
Research Aimed at Improving Both Mood and Weight
The RAINBOW study is an NIH R01-funded randomized controlled trial to evaluate the clinical and cost effectiveness and implementation potential of a primary care integrated multicondition intervention program to help improve mood…
- Trial name
- RAINBOW-ENGAGE (NCT02246413)
- Testing
- RAINBOW Intervention Program
- Where
- 2 sites in United States
- Volunteers
- 409 people
- Sponsor
- Palo Alto Medical Foundation
Major Depressive Disorder
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and physical symptoms such as…
- Trial name
- NCT07276997
- Testing
- Icalcaprant
- Where
- 33 sites in United States
- Volunteers
- 195 people
- Sponsor
- AbbVie
Physiological Effects of Drugs
Memantine for Corticosteroid-Induced Mood and Declarative Memory Changes
The purpose of this research is to determine if patients on corticosteroids who are given memantine will show improvement in memory compared to those receiving placebo (an inactive substance).
- Trial name
- NCT00280774
- Testing
- Memantine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Bereavement, Depressive Disorder
Consequences of Conjugal Bereavement in Adults
Bereavement refers to the expected reactions and sadness associated with the loss of a loved one. It has been reported that the loss of a spouse is rated as the major life stressor among survivors of varying ages and diverse…
- Conditions
- Bereavement, Depressive Disorder, Immunologic Disease, Mental Disorder
- Trial name
- NCT00001659
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Irritability
Attention Bias Modification, Attention Control and Psychoeducation for Irritability in Children and Adolescents
The aim of this project is to evaluate the efficacy of an attention bias modification training if compared to an attention control and psychoeducation to reduce the symptoms of irritability among children with high levels of…
- Trial name
- NCT03238118
- Testing
- Attention bias modification training, Attention Control Training, Psychoeducation
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Major Depression
Changes of Functional Connectivity After rTMS in Depression
In order to explore the effect of repetitive TMS, which has shown to be effective in intractable depression, we will examine resting-state, default-mode network functional connectivity in patients with major depression.
- Trial name
- NCT01325831
- Testing
- repetitive transcranial magnetic stimulation(rTMS)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Major Depressive Disorder
Supportive and Supportive-Expressive Treatment for Depression
This study will assign patients to two types of psychotherapies in treating people with a major depression disorder, expressive versus supportive techniques, and will examine their ability to benefit from treatment based on their…
- Trial name
- SSETD (NCT02728557)
- Testing
- Supportive-Expressive Therapy, Supportive Therapy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- University of Haifa
Bipolar Disorder
N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder
We propose to conduct a double-blind placebo-controlled trial with a widely available and prototypical non-steroidal anti-inflammatory agent, aspirin, and an antioxidant agent, NAC, involving symptomatic Bipolar Disorder type I…
- Trial name
- SMRI-Bipolar (NCT01797575)
- Testing
- Aspirin, N-acetyl-cysteine (NAC), Sugar Pill
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- The University of Texas Health Science Center, Houston
Borderline Personality Disorder, Emotional Instability
Using Smartphones for Selfmonitoring of Skill-use i Dialectical Behavior Therapy
BACKGROUND: Borderline Personality Disorder (BPD) is a serious and debilitating mental disease characterized by difficulties with emotion regulation that leads to unstable and self- destructive behavior and relationships.
- Conditions
- Borderline Personality Disorder, Emotional Instability, Skill, Coping
- Trial name
- mDIARY (NCT03191565)
- Testing
- Paper diary sheet, Monsenso DBT-app and IT monitoring program
- Where
- 5 sites in Denmark
- Volunteers
- 78 people
- Sponsor
- Region of Southern Denmark
Nutrient Deficiency, Happiness
Alii Supplement Study
The goal of this clinical trial is to learn if the Alii Supplement can be used to reduce symptoms related to nutritional depletion in hormonal birth control pill users.
- Conditions
- Nutrient Deficiency, Happiness, Digestive Health, Vulnerability to Disease
- Trial name
- NCT07271316
- Testing
- Alii Supplement
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Texas Christian University
Mood, Cognitive Change
Hypo-hydration Mood and Cognition
Recently changes in mood and cognition have been reported following minor reductions in hydration status. The aim is to explore that such changes in part at least reflect placebo response; therefore the consumption of plain or…
- Trial name
- NCT03948230
- Testing
- Salt with / without water
- Where
- 2 sites in United Kingdom
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Swansea University
Schizophrenia, Bipolar Disorder
Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI
The goal of this project, which has not changed, is to evaluate the statewide implementation of a two-component intervention (health promotion plus academic detailing) with respect to consumer outcomes and changes in provider…
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT02334280
- Testing
- In SHAPE
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Schizophrenia, Schizoaffective Disorder
An Open-label Trial of Metformin for Weight Control of Pediatric Patients on Antipsychotic Medications.
The aim of this study is to evaluate the effectiveness, safety, and tolerability of metformin treatment in children and adolescents suffering from weight gain secondary to use of atypical antipsychotic medications.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Bipolar Disorder
- Trial name
- NCT00391261
- Testing
- Metformin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cambridge Health Alliance
Sleep, Diet Modification
Diet and Sleep Monitoring
This study will investigate the effect of two dietary patterns on sleep outcomes and measures of reported appetite. Participants will be given two different diets on two separate stays.
- Trial name
- NCT03257137
- Testing
- Diet Quality
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Alzheimer Disease
REXULTI General Use Results Survey in Patients With Hyperactivity, or Aggressive Behavior Associated With Alzheimer's Dementia
The purpose of this study is to evaluate safety of REXULTI in patients under daily clinical settings. In addition, information on efficacy will be collected.
- Trial name
- NCT06875986
- Testing
- Brexpiprazole (Rexulti)
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.