Clinical trials: Mood Disorders
Mental Health, Cultural Adaptation
Digital Mental Health for Asian Americans
Aim 1: Assess clinicians' receptiveness and potential use of Anise's online platform digital tools for managing sociocultural stressors and revise the tools for implementation.
- Conditions
- Mental Health, Cultural Adaptation, Psychotherapy, Mood Disorders
- Trial name
- NCT07771322
- Testing
- Culturally-attuned digital tools
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Premenstrual Syndrome, Menstrual Pain
A Clinical Study to Assess the Effect of a Dietary Supplement on Menstrual Cycle Symptoms
This is a single-group, virtual clinical trial evaluating the effects of a daily dietary supplement (DITTO Cycle Supplement) on menstrual cycle symptoms across three menstrual cycles.
- Trial name
- NCT07267728
- Testing
- DITTO Cycle Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Muse Nutrition Ltd
Major Depressive Disorder, Post-Traumatic Stress Disorder
Examination of Glutamate and mGluR5 in Psychiatric Disorders
This research study is designed to look at the involvement of the glutamate system in depression. Each subject will undergo a screening appointment to determine study eligibility.
- Conditions
- Major Depressive Disorder, Post-Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT02727972
- Testing
- Cognitive Testing, MRI, PET
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Cognitive Performance, Memory
Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health
Previous studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive…
- Conditions
- Cognitive Performance, Memory, Mood, Anxiety
- Trial name
- NCT05541887
- Testing
- Muscadine Wine Polyphenol
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Florida
Gastrointestinal Symptoms, Bloating
A Clinical Trial to Evaluate the Effects of Super Liver Liquid Drops on Gut Health, Digestive Comfort, and Daily Energy Levels
This is a decentralized (fully virtual), single-group, open-label, prospective clinical trial evaluating the effects of Super Liver Liquid Drops, a liquid botanical dietary supplement, on gut health, digestive comfort, energy…
- Conditions
- Gastrointestinal Symptoms, Bloating, Digestive Discomfort, Low Energy Levels
- Trial name
- NCT07742657
- Testing
- Super Liver
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- SuperBonsai Inc.
Perinatal Depression, Affective Disorder
Validation of the French Version of the Perinatal Assessment of Paternal Affectivity (PAPA)
The transition to parenthood is a critical period for both the woman and her partner, and this can affect the mental health of the parents.
- Conditions
- Perinatal Depression, Affective Disorder, Fathers
- Trial name
- French-Papa (NCT06594263)
- Where
- France
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Sleep Quality, Mood
A Clinical Trial to Evaluate the Effects of the Edge+Ease PM+AM System on Mood, Mental Clarity, Sleep Quality, and Digestive Wellbeing
This is a decentralized, single-arm, open-label clinical trial evaluating the effects of the Edge+Ease PM+AM dietary supplement system on sleep quality, mood, mental clarity, focus, and digestive comfort in 35 generally healthy…
- Conditions
- Sleep Quality, Mood, Mental Clarity, Brain Fog
- Trial name
- NCT07721506
- Testing
- Edge+ease PM
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Edge+Ease
Well-Being, Psychological, Mood
Mushrooms, Mood and Mental Wellbeing in Gen Z Women
The aim of the study is to investigate the effects of 28 days supplementation of Lions mane mushroom and mushroom blend of Lions mane and reishi mushroom, on wellbeing in stressed or anxious women.
- Conditions
- Well-Being, Psychological, Mood, Anxiety, Stress
- Trial name
- NCT06406946
- Testing
- Lion's mane blend, Lion's mane and reishi blend
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Mood Disorders, Depressive Disorder
An Innovative Master Platform for Clinical Trials in Mood Disorders
Mood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person.
- Conditions
- Mood Disorders, Depressive Disorder, Bipolar and Related Disorders
- Trial name
- ENABLE (NCT06408012)
- Where
- 9 sites in Canada
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Depression / Major Depressive Disorder, Mood
Intern Health Study 2026
The aim of this study is to evaluate the efficacy of using a reinforcement learning algorithm to determine the optimal content of a mobile health intervention (message delivered via smartphone) for improving the mood, physical…
- Conditions
- Depression / Major Depressive Disorder, Mood, Sleep, Physical Activity
- Trial name
- IHS 2026 (NCT07685925)
- Testing
- Intern Health Study behavioral change mobile notification
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sleep, Circadian Rhythm
Morning Bright Light Therapy and Daytime Functioning in University Students
This study tests whether a week of morning bright light therapy changes how well healthy young adults sleep and how alert, positive, and mentally sharp they feel during the day.
- Conditions
- Sleep, Circadian Rhythm, Daytime Sleepiness, Mood
- Trial name
- BLIGHT (NCT07685262)
- Testing
- Bright light therapy (10,000 lux light box)
- Where
- Hong Kong
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Emotion Management Skills, Lifestyle, Healthy
The Impact of Enhanced Music & Natural Visuals on Emotional Health
The investigators are conducting research on factors related to the self-regulation of mood and arousal states across a range of everyday activities as well as different levels of stress.
- Conditions
- Emotion Management Skills, Lifestyle, Healthy, Lifestyle Intervention, Recovery
- Trial name
- NCT07676110
- Testing
- soundBrilliance software application - Emotional Health
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- soundBrilliance LLC
Postpartum Depression, Mood Disorders
Whole-Body Hyperthermia for Mood and Anxiety Disorders
This study aims to examine the scientific mechanisms of whole-body hyperthermia (WBH), a novel, rapidly acting, single session antidepressant and anxiolytic therapy.
- Conditions
- Postpartum Depression, Mood Disorders, Anxiety Disorders, Postpartum Anxiety
- Trial name
- NCT06144294
- Testing
- Whole-Body Hyperthermia, fMRI
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Insomina, Mood Change
Integrating Smart Wearable Device Into Digital Insomnia Treatment Application: Exploration of Combining Emotional and Lifestyle Records
Emotions, behavior, and cognition are the main factors contributing to insomnia. Insomnia not only affects sleep quality but also harms health, quality of life, and daytime functioning.
- Trial name
- NCT07600840
- Testing
- Personalized Experience Sampling Method, Non-personalized Experience Sampling Method
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Technology
Mood Disorders, Major Depressive Disorder
Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)
Mood disorders are associated with significant financial and health costs for the United States, partially due to cognitive problems in these patients that can worsen disease course and impair treatment response.
- Conditions
- Mood Disorders, Major Depressive Disorder, Bipolar Disorder I, Bipolar Disorder II
- Trial name
- UnMASCK (NCT04358900)
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Mood Disorders, Anxiety Disorders
Reconnecting to Ourselves and Others in Virtual Meetings (ROOM)
This study aimed to determine the feasibility and acceptability of delivering Resilience Training in multi-user virtual reality.
- Conditions
- Mood Disorders, Anxiety Disorders, Psychotic Disorders
- Trial name
- NCT06360562
- Testing
- Resilience Training
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression, Anxiety
Mental Health Impact of the COVID-19 Pandemic on Amish and Mennonite Participants in AMBiGen
People have had to make a lot of changes to their lives due to the COVID-19 health crisis. Most experts agree that social distancing and other safety measures have taken a toll on people s mental health.
- Conditions
- Depression, Anxiety, Bipolar Disorder
- Trial name
- NCT04684615
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Anxiety Disorders
Focused Ultrasound Amygdala Neuromodulation
The purpose of the study is to examine the feasibility and potential efficacy of low-intensity focused ultrasound as a method of modulating amygdala function to promote improvements in symptoms of an affective disorder.
- Conditions
- Depression, Anxiety Disorders, Bipolar Depression, Ptsd
- Trial name
- NCT05228964
- Testing
- Focused ultrasound
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Anxiety, Panic Disorder
Investigation of Pathogenic Gut Microbiota Patterns in Anxiety, Depression and Panic Disorders
This study aims to investigate the etiology of anxiety, depression, and panic disorders, providing new evidence and insights into the root causes and effective treatments, potentially offering a novel approach to achieving…
- Conditions
- Anxiety, Panic Disorder, Mood Disorders, Depression
- Trial name
- NCT07268729
- Testing
- H pylori stool test, Bacterial stool analysis
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Psychiatric Disorders Mood, Anhedonia
Pramipexole for Anhedonic Depression
The heterogeneity of depression suggests that several different neurocircuits and pathophysiological mechanisms are involved. Anhedonia - the inability to experience pleasure from, or the lack of motivation to carry out, usually…
- Conditions
- Psychiatric Disorders Mood, Anhedonia, Depression
- Trial name
- PRIME-PRAXOL (NCT05355337)
- Testing
- Pramipexole
- Where
- Sweden
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Region Skane