Clinical trials: Mood Disorders
Postpartum Depression
Preventing Postpartum Depression in Immigrant Latinas
Postpartum depression (PPD) affects 10-20% of women, with immigrant Latinas disproportionately affected. PPD prevention and treatment is limited among immigrant Latinas due to an array of structural and cultural factors…
- Trial name
- NCT05873569
- Testing
- Mothers and Babies Virtual Group Intervention
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Major Depressive Disorder
Piloting a Novel, Mobile Cognitive Training Tool for Patients With Major Depressive Disorder (MDD)
To assess the efficacy of a mobile-device-deployed cognitive emotional treatment for depression (Moodify) versus an active control treatment (commercially available computer games).
- Trial name
- MDD (NCT02922556)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Cognitive Function and Mood, Cerebral Blood Flow
The Effects of Resveratrol Supplementation on Cognition, Cerebral Blood Flow, Microbiota and Systemic Inflammation.
Previous research shows that a diet high in fat has harmful effects on gut health. This increases the chance of developing obesity-related diseases (such as type 2 diabetes) and disrupts cognition and mood.
- Conditions
- Cognitive Function and Mood, Cerebral Blood Flow, Systemic Inflammation, Gut Microbiota
- Trial name
- NCT03448094
- Testing
- Resveratrol
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Postpartum Depression, Anxiety
Mothers and Babies Qatar (MB-Q): A Postpartum Depression Intervention
Qatar Mothers and Babies is a 4-year collaboration between Northwestern University Feinberg School of Medicine and Sidra Medicine in Doha, Qatar that will generate and evaluate a cultural and contextual adaptation of the Mothers…
- Conditions
- Postpartum Depression, Anxiety, Diabetes
- Trial name
- MB (NCT04442529)
- Testing
- Mothers and Babies (MB)
- Where
- Qatar
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sidra Medicine
Depression, Bipolar Disorder
Prevention of Mood Disorders by Folic Acid Supplementation
The purpose of this study is to determine whether daily folic acid supplements can prevent new episodes of mood disorder in young people (aged 14-24 years) of biological parents with current or past history of depression or…
- Trial name
- PRE-EMPT (NCT00459264)
- Testing
- Folic Acid
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Major Depressive Disorder
Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression
This study looks at the role of the Nociceptin/Orphanin FQ receptor system in the brain of individuals with current or past major depressive disorder (MDD).
- Trial name
- NCT05630963
- Testing
- Aversive stimuli, PET radiotracer
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression, Postpartum
The Impact of Creative Interventions on Symptoms of Postnatal Depression (Cohort Study)
Post-natal depression (PND) is anticipated to affect 12.9% of new mothers with at least 75,000 cases per year in the UK alone. However, despite this, there is currently a worrying lack of support for new mothers, with data…
- Trial name
- NCT02526433
- Where
- United Kingdom
- Volunteers
- 2,558 people, healthy volunteers welcome
- Sponsor
- Royal College of Music
Bipolar Disorder, Bipolar and Related Disorders
Targeted Alternating Current and Cognitive Training Intervention for Cognitive Control in Bipolar Disorders
This study is testing whether a type of gentle brain stimulation, combined with computer-based brain training exercises, can help improve thinking skills in Veterans with bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar and Related Disorders, Veterans, Suicide
- Trial name
- TACTIC-BD (NCT07845409)
- Testing
- Soterix 1x1 tES mini-CT
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Perinatal Depression
Early Detection of Perinatal Depression With Wearable Technology
The goal of this feasibility study is to learn whether wearable devices and self-report surveys can help researchers better understand changes in mood during pregnancy and after birth in young pregnant individuals with a history…
- Trial name
- BLUESMAPPED (NCT07784244)
- Testing
- Oura Ring (Photoplethysmography-based wearable ring), EmbracePlus Watch (Electrodermal activity wristband sensor)
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Major Depression
Serum Markers as a Bioassay for Unipolar Depression
The goal of the study is to validate a biomarker assay for unipolar depression based on serum proteins involved in inflammation, metabolism, and stress response.
- Trial name
- NCT00825799
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Bipolar, Depression
Adjunctive Lisdexamfetamine (LDX) in Bipolar Depression
The specific aim of this study is to evaluate the efficacy and tolerability of lisdexamfetamine in the adjunctive treatment of bipolar disorder.
- Trial name
- NCT01131559
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lindner Center of HOPE
Depressive Disorder, Major, Bipolar Disorder
Psychiatric Genotype/Phenotype Project Repository
The purpose of this project is to obtain DNA, brain imaging data, other biological samples (e.g., urine, serum), and a comprehensive clinical assessment on patients with schizophrenia and other psychotic disorders, bipolar…
- Conditions
- Depressive Disorder, Major, Bipolar Disorder, Psychotic Disorders
- Trial name
- PGPP (NCT00762866)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Depression, Mood Disorders
Functional MRI Before and After Treatment for Depression
The purpose of this study is to help us understand how depression changes brain activity and how this relates to mood, anxiety, and cognitive functions like memory.
- Conditions
- Depression, Mood Disorders, Depressive Disorder
- Trial name
- NCT00896441
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Stanford University
Major Depression, Bipolar Disorder
Longitudinal Study of People Presenting for First Treatment of a Mood Disorder
The goal of this project is to study the course and outcome of illness in individuals who present with a first episode of depression or mania, or who have a recurrent disorder but have never received treatment.
- Trial name
- NCT01529905
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postnatal Depression
Postnatal Depression, Attachment and Self-defining Memories
The specificity of postnatal depression (PND) was acted as full entity within the depressions, by B. Pitt in 1968, through the description of a specific nosography which describes "an atypical depression of the post-partum ".
- Trial name
- PNDattachMEMO (NCT03346551)
- Testing
- Evaluation of the quality attachment : "Adult Attachment Narratives" and "CaMir scale", Evaluation of the self-defining memories : "Specific Questionnaire during an interview"
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Bipolar Disorder, Caregiver Burden
Evaluation of Efficiency of One Day Patient/Caregiver Psychoeducation on the Caregiver's Burden
Bipolar disorder (BD) has a huge impact on the lives of patient and their relatives. Psychoeducation programs on BD has been shown to be effective on the burden of patients and their caregivers.
- Trial name
- BP ONEDAY (NCT05178966)
- Testing
- Bp OneDay psychoeducation program
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Major Depressive Disorder
Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression
This study will apply a comprehensive tools that integrates neuroimaging, psychological evaluation, and sleep monitoring through 18F-MPPF PET/MR, neuropsychological tests, and polysomnography (PSG) to explore the neurobiological…
- Trial name
- NCT06211140
- Testing
- tACS, Control
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Bipolar Disorder (BD)
Pramipexole vs Placebo Treatment in Bipolar Disorder With Anhedonic Depression
Among psychiatric disorders, bipolar disorder stands out due to its alarmingly high suicide rates. This condition presents unique management challenges, especially during its depressive phase, which carries the highest risk of…
- Trial name
- B-HAPPI (NCT07664852)
- Testing
- Pramipexole
- Where
- Sweden
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Daniel Lindqvist
Depressive Disorder, Fatigue Syndrome, Chronic
Glucocorticoid Effects on Cellular Cytokine Release
A variety of hormones and immune system processes are responsible for how the body responds to illness. This study concentrates on how the hormone cortisol effects the release of immune system factors called cytokines.
- Conditions
- Depressive Disorder, Fatigue Syndrome, Chronic, Fibromyalgia, Healthy
- Trial name
- NCT00001415
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Subthreshold Depression, Exercise
The Effect of Exercise on Cognition and Preventing Depression in Young People
It is estimated that approximately 30% of child and adolescents manifest subthreshold depression (including other specified depressive disorder and unspecified depressive disorder), which can further develop into major depression…
- Conditions
- Subthreshold Depression, Exercise, Clinically-well, Cognitive Change
- Trial name
- NCT04816617
- Testing
- Aerobic exercise intervention, Psycho-education
- Where
- China
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
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