Clinical trials: Morbidity, Multiple
Thoracic Aorta Dilatation, Marfan Syndrome
Thoracic Aortic Dilatation Syndromes
Aortic dilatation syndromes are comprised by a group of different syndromes, of which Marfan syndrome is the best described. Many of the aorta dilatation associated syndromes are heritable connective tissue disorders but some…
- Trial name
- NCT02111668
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Morbidity;Newborn, Morality
Improving Outcome of Very Preterm Infants Using Collaborative Quality Improvement
A multicenter interventional study using evidence-based collaborative quality improvement to reduce mortality and major morbidities of very preterm infants in six neonatal centers in Shanghai
- Trial name
- NCT04531839
- Testing
- Evidence-based collaborative quality improvement
- Where
- 6 sites in China
- Sponsor
- Children's Hospital of Fudan University
Acute Cholecystitis, Pain
Comparison of Morbidity After Laparoscopic Cholecystectomy for Acutely Inflamed Gall Bladder With and Without Drain
The purpose of this study was to compare the frequency of pain and mean hospital stay in patients with and without drain insertion, following laparoscopic cholecystectomy for acutely inflamed gallbladder.
- Conditions
- Acute Cholecystitis, Pain, Morbidity, Multiple, Surgery
- Trial name
- NCT04346550
- Testing
- Suction drain
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shifa International Hospital
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Coronary; Ischemic, Arrhythmias, Cardiac
Influence of a Multi-parametric Optimization Strategy for General Anesthesia on Postoperative Morbidity and Mortality
With the increasing aging population demographics and life expectancies, the number of very elderly patients undergoing surgery is rising.
- Conditions
- Coronary; Ischemic, Arrhythmias, Cardiac, Heart Failure, Peripheral Vascular Diseases
- Trial name
- OPTI-AGED (NCT02668250)
- Testing
- OPTI-AGED, Usual Care
- Where
- 29 sites in France
- Volunteers
- 2,495 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Coronary Artery Disease
TEAM-Project: Trial on the Effect of Anesthetics on Morbidity and Mortality
Volatile anesthetics may provide some protection from myocardial ischemia, an effect called anesthetic preconditioning. In patients undergoing coronary artery bypass surgery, this preconditioning effect resulted in better cardiac…
- Trial name
- NCT00286585
- Testing
- Inhalational anesthetic, Intravenous anesthetic, propofol
- Where
- 3 sites in Switzerland
- Volunteers
- 385 people
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Pain, Morbidity, Multiple
Registry of Coronavirus Complications - CORRELATION WITH GLYCOMIC PROFILE in COVID-19 Patients
COVID infection has resulted in multi-organ injury and may result in cardiovascular, pulmonary, neurological, and muscular damage.
- Conditions
- Chronic Pain, Morbidity, Multiple, Covid19
- Trial name
- ROCCO (NCT04788433)
- Testing
- glycomic analysis, Phone interview
- Where
- Italy
- Volunteers
- 374 people
- Sponsor
- Papa Giovanni XXIII Hospital
Asthma, Multi Morbidity
LIving BEtteR With asThma studY:: A Multimodal Intervention to Address Multimorbidity in Difficult Asthma
Multimorbidity is a significant issue for many patients with difficult asthma. With patients, we have co-designed a multimodal intervention comprising prescribed exercise, dietary support, breathing pattern retraining and…
- Trial name
- LIBERTY (NCT06513117)
- Testing
- Behaviour change, Dietary support, Breathing pattern retraining
- Volunteers
- 30 people
- Sponsor
- University of Southampton
Dementia, Postoperative Delirium (POD)
Prediction and Prevention of Postoperative Mortality and Morbidity
This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive…
- Conditions
- Dementia, Postoperative Delirium (POD), Postoperative Neurocognitive Disorder, Major Adverse Cardiac and Cerebrovascular Events
- Trial name
- NCT06042413
- Testing
- Personalized CPC Prehabilitation, Cognitive Training, Meditation
- Where
- 5 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pittsburgh
Obesity, Bariatric Surgery Candidate
Multi-Strategy Intervention for Anesthesia Care of Obese Patients A Factorial Randomized Controlled Trial
The main objective of this study is to investigate the optimal anesthesia for obese patients undergoing bariatric surgery in the strategies of positive pulmonary ventilation, tracheal intubation technique, hemodynamic monitoring…
- Conditions
- Obesity, Bariatric Surgery Candidate, Tracheal Intubation Morbidity, Nausea and Vomiting, Postoperative
- Trial name
- NCT05016076
- Testing
- Dexamethasone 8 mg, Applied inspiratory pressure (10, 15, 20, or 25 cmH2O), Tracheal intubation using video intubating stylet, video laryngoscopy, or direct laryngoscopy
- Where
- Taiwan
- Sponsor
- YingHsuanTai
Multimorbidity
Navigation for Elderly People With Multiple Morbidity After Hospital Discharge.
This research aims to create and test a tracking (navigation) model to assist in providing care guidance to elderly people (60 years or older) who have two or more chronic diseases at the same time (multimorbidity) immediately…
- Trial name
- NAVIM (NCT07546006)
- Testing
- Navigation for elderly people after hospital discharge., Routine care.
- Where
- Brazil
- Volunteers
- 148 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Frailty, Morbidity, Multiple
Low-volume Cycling Training in Older People With Multimorbidity
INTRODUCTION: Physical exercise, when practiced regularly and in adequate doses, is a proven nonpharmacological measure that helps to prevent and reverse noncommunicable diseases, as well as reduce mortality rates from any cause.
- Trial name
- NCT04842396
- Testing
- Experimental:Motorized cycle ergometer
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Universidade da Coruña
Multiple Sclerosis
Reducing Sedentary Behaviour: A Novel Opportunity for Managing Comorbidity in MS?
Activity recommendations for the general population and those with multiple sclerosis (MS) focus on the promotion of activity that has a moderate intensity - in other words, activity intense enough to breathe heavily and sweat.
- Trial name
- NCT03136744
- Testing
- Sit Less with MS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Multiple Co-morbidities
Computer Assisted Symptom Evaluation of Complex Patients
Patients who have advanced or multiple chronic illnesses present management difficulties for primary care providers. Acute medical issues and limited time for patient evaluation can complicate complete assessment of physical…
- Trial name
- CASE (NCT01391026)
- Testing
- Enhanced patient-centered care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Cook County Health
Diet, Healthy, HbA1c
MTM2MTG Pilot Ancillary Study
The investigators will conduct an ancillary study of participants in a completed RCT of medically tailored meals to determine whether transitioning these participants to a medically tailored groceries (MTG) program is a feasible…
- Conditions
- Diet, Healthy, HbA1c, Blood Pressure
- Trial name
- MTM2MTG (NCT07620808)
- Testing
- Medically Tailored Groceries
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Columbia University
Chronic Obstructive Pulmonary Disease (COPD), Asthma
Mitigating Chronic Respiratory Disease Through the Lens of Multi-Morbidity
The investigators aim to make it easier to find people with undiagnosed long-term lung health problems (such as asthma, and chronic obstructive pulmonary disease, COPD, collectively called 'Chronic Respiratory Diseases', CRDs)…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma, Preserved Ratio Impaired Spirometry
- Trial name
- MARES1 (NCT07050823)
- Where
- 2 sites in Brazil
- Volunteers
- 859 people
- Sponsor
- University College, London
Old Age, Family Members
The Chit-Chat Educational Intervention to Promote Advance Care Planning in the Community
The purpose of this study is to estimate the effect size of the Chit-Chat intervention on ACP engagement among family members of older adults with multi-morbidity.
- Trial name
- NCT06296719
- Testing
- Chit-Chat
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Perioperative/Postoperative Complications, Morbidity, Multiple
Machine Learning Modeling of Intraoperative Hemodynamic Predictors of Postoperative Outcomes
With population aging and limited resources, strategies to improve outcomes after surgery are ever more important. There is a limited understanding of what ranges of hemodynamic variables under anesthesia are associated with…
- Conditions
- Perioperative/Postoperative Complications, Morbidity, Multiple, Surgery, Anesthesia
- Trial name
- NCT04014010
- Testing
- Blood pressure, Heart rate, Use of hemodynamic medications (i.e. special medications for blood pressure)
- Volunteers
- 35,000 people
- Sponsor
- Janny Xue Chen Ke
Hypertension, Diabetes Mellitus, Type 2
Enhancing Community Health Through Patient Navigation, Advocacy and Social Support
Some patients who have multiple long-term health conditions have significant challenges accessing needed services despite available primary care and social services resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT03077386)
- Testing
- ENCOMPASS Intervention
- Where
- Canada
- Volunteers
- 176 people
- Sponsor
- University of Calgary
Obesity
Efficacy and Safety of Liraglutide on Body Weight in Obese Subjects or Overweight Subjects With Co-morbidities
We performed a multicenter, randomized, double-blind, placebo-controlled 28-week trial. 300 non-diabetic obese subjects or overweight subjects with co-morbidities were randomly assigned.
- Trial name
- NCT04487743
- Testing
- Liraglutide
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xiangya Hospital of Central South University