Clinical trials: Morphologic Change
The Lamina Cribrosa and Optic Nerve Head Changes
The Lamina Cribrosa (LC) Changes in the Eyes After Laser-Assisted in Situ Keratomileusis (LASIK)
The burden of LASIK surgery on optic nerve head (ONH) has been controversial. Until now, the change of retinal nerve fiber layer (RNFL) thickness was used as the indicator of the study.
- Trial name
- NCT02676557
- Testing
- Exposed to the high pressure during the surgery
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Morphologic Change
IVUS Study for SV Graft: Y-composite vs Aortocoronary Conduit
Left internal thoracic artery (LITA) has been acknowledged as the first graft of choice for coronary artery bypass grafting (CABG).
- Trial name
- CONFIG (NCT04782492)
- Testing
- graft configuration in coronary artery bypass grafting
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Ho Young Hwang
Obesity, Obstructive Sleep Apnea
Changes in Body Fat and Morphologic Characteristics Associated With OSA Resolution After Bariatric Surgery
Prospective study with inclusion of bariatric surgery candidates with diagnosed Obstructive Sleep Apnea and requiring treatment with Continuous Positive Air Pressure, aiming to evaluate at 2-6-12 months after bariatric surgery…
- Trial name
- NCT05315752
- Testing
- Bariatric surgery
- Where
- 2 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Morphologic Change, Number of Roots
Assessment of the Relationship Between Mandibular Third Molars' Roots & the Covering Lingual Cortex Among Egyptian Population Using CBCT
A cross-sectional study to assess the Topographic Relationship between Mandibular Third Molars' Roots and the Covering Lingual Cortex in a Sample of Egyptian Population using CBCT through retrospective data analysis
- Trial name
- NCT04567654
- Volunteers
- 304 people
- Sponsor
- Cairo University
Congenital Cataract Surgery, IOL Implantation
Corneal Endothelial Changes Following Pediatric Cataract Surgery With IOL Implantation
Cataract surgery is known to cause loss of corneal endothelial cells. In adults, it is reported that anywhere between 2 to 15% loss of corneal endothelial cell density occurs following cataract surgery.
- Conditions
- Congenital Cataract Surgery, IOL Implantation, Change in Corneal Endothelial Cell Morphology
- Trial name
- NCT01504607
- Testing
- Congenital Cataract Surgery
- Volunteers
- 106 people
- Sponsor
- Iladevi Cataract and IOL Research Center
Mitral Valve Insufficiency, Heart Septal Defects, Atrial
MitraClip® and Hemodynamic Effects of Relevant Iatrogenic Atrial Septum Defect Closure
Aim of this prospective trial is to assess the hemodynamic effects of a MitraClip procedure caused iatrogenic arterial septal defect (iASD) and the functional changes after interventional iASD closure in a randomized setting.
- Trial name
- NCT03024268
- Testing
- Figulla Flex Occluder (Occlutech)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Heart Center Leipzig - University Hospital
Epiretinal Membrane, Macular Pucker
Morphologic Changes After Membrane Peeling With Air Tamponade and Balanced Salt Solution
During the last decade optical coherence tomography (OCT) extended the possibilities for in vivo macula diagnostic and was increasingly used for pre- and post-operative imaging of retinal diseases.
- Trial name
- NCT02319655
- Testing
- Air tamponade, Balanced salt solution filling
- Where
- Austria
- Volunteers
- 85 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Gender Dysphoria, Hormone Therapy Induced Morphologic Change
Gender-Affirming Hormone Therapy and Its Impact on Myocardial Mass and Cardiac Function, Heart, Liver and Pancreatic Fat Content
Background: Gender affirming hormone therapy (GAHT) leads to profound changes in sex hormone levels, carrying a wide range of implications for major physiological processes in the body.
- Trial name
- NCT06291675
- Testing
- gender-affirming hormone therapy
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 1 Diabetes, Cardiovascular Risk Factor
Determinants of Cardiovascular Disease Risk Factors Among Youth With Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is the most common form of diabetes among children and youth, and it is increasing around the world, particularly among children under 5 years.
- Trial name
- CARDEA (NCT04304729)
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Endometrial Adenocarcinoma, Endometrial Adenosquamous Carcinoma
Medroxyprogesterone in Treating Patients With Endometrioid Adenocarcinoma of the Uterine Corpus
This phase II trial is studying how well medroxyprogesterone works in treating patients with endometrioid adenocarcinoma (cancer) of the uterine corpus (the body of the uterus, not including the cervix).
- Conditions
- Endometrial Adenocarcinoma, Endometrial Adenosquamous Carcinoma, Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation, Recurrent Uterine Corpus Carcinoma
- Trial name
- NCT00064025
- Testing
- Laboratory Biomarker Analysis, Medroxyprogesterone, Therapeutic Conventional Surgery
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Gynecologic Oncology Group
Subacromial Impingement Syndrome, Morphologic Change
Conservative Physiotherapy and Acromion Morphology
In this study, we aimed to evaluate the short-term effects of conservative physiotherapy in the subacromial impingement syndrome (SIS) and its relation to the acromion morphology.
- Trial name
- NCT04392934
- Testing
- a conservative physiotherapy protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hasan Kalyoncu University
Tooth Discoloration, Morphologic Change
Influence of Polishing After Bleaching on Color Change and Enamel Morphology
This trial evaluated the influence of polishing on enamel color change after in-office bleaching treatment. It also evaluated the influence of polishing on tooth morphology and sensitivity.
- Conditions
- Tooth Discoloration, Morphologic Change, Tooth Sensitivity
- Trial name
- NCT05635253
- Testing
- Hydrogen Peroxide 35%, Hydrogen Peroxide 35% + Polishing whitened teeth
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma
Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer
This randomized surgical window trial evaluates the effect of adding entinostat to medroxyprogesterone acetate before surgery works on progesterone receptors on endometrioid endometrial tumors.
- Conditions
- FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma, FIGO Grade 3 Endometrial Endometrioid Adenocarcinoma
- Trial name
- NCT03018249
- Testing
- Entinostat, Hysterectomy, Laboratory Biomarker Analysis
- Where
- 234 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes Mellitus, Type 2, Nutritional and Metabolic Diseases
Efficacy and Safety of Nutraceuticals in Patients With Diabetes Mellitus Type II and Dyslipidemia.
The presence of dyslipidemia, is a significant cardiovascular risk factor. This factor, however, determines the three-fold increase in cardiometabolic risk when an isolated or mixed dyslipidemia is associated with the presence of…
- Conditions
- Diabetes Mellitus, Type 2, Nutritional and Metabolic Diseases, Vascular System Injury, Therapy-Related Morphologic Change
- Trial name
- NCT03676309
- Testing
- Nutriceutical Oral Capsule,
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Villa dei Gerani
Hormone Therapy Induced Morphologic Change, Surgical Menopause
Hormone Therapy on Serum Ischemia Modified Albumin in Menopausal Women
Women suffer from cardiovascular diseases 10 years later than men, therefore female sex has been considered as a 'protective factor'.
- Trial name
- NCT04424108
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University