Clinical trials: Mortality
Cardiovascular Disease, Diabetic Nephropathy
Effect of a Vitamin D Analogue vs Placebo on p-NT-proBNP in Patients With Type 1 DM and Diabetic Nephropathy
The primary objective is to assess the impact of three months of treatment with an active vitamin D analogue on a risk marker for excess overall mortality and cardiovascular morbidity/mortality in Type 1 diabetic patients with…
- Trial name
- NCT01331317
- Testing
- Paricalcitol
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Peter Rossing
Aging, Aging Well
100-Year Human Aging Study
The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo…
- Conditions
- Aging, Aging Well, All-Cause Mortality, Mortality
- Trial name
- NCT07563777
- Testing
- Comprehensive Multi-System Clinical Screening
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Percutaneous Coronary Intervention (PCI), Acute Myocardial Infarction
Aerobic Exercise-induced Effect on Endothelial Function in Patients With Ischaemic Heart Disease
Endothelial dysfunction is one of the aetiological factors in ischaemic heart disease (IHD). Aerobic exercise is effective in improving endothelial function, as measured by flow-mediated dilation (FMD), in patients with IHD.
- Conditions
- Percutaneous Coronary Intervention (PCI), Acute Myocardial Infarction, Angina (Stable), Unstable Angina Pectoris
- Trial name
- ENDO-R (NCT06788275)
- Testing
- Aerobic exercise (MIT), Aerobic exercise (Short HIIT), Aerobic exercise (Long HIIT)
- Where
- 2 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante
Heart Failure
A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines
In an earlier study, eplerenone was shown to improve survival in patients who had heart failure immediately following a heart attack.
- Trial name
- EMPHASIS-HF (NCT00232180)
- Testing
- Eplerenone
- Where
- 307 sites in United States, Argentina and 27 more
- Volunteers
- 2,743 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Sepsis
Urine Interleukin-37 as a Biomarker of Mortality Risk in Patients With Sepsis
This study aims to evaluate the efficacy of IL-37 as a biomarker to predict mortality risk in adults with sepsis.
- Trial name
- NCT05640037
- Where
- China
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Subarachnoid Hemorrhage, Aneurysmal
Predicting 28-Day Mortality in Subarachnoid Hemorrhage
The investigators investigated the predictive ability of clinical and radiological scores, including the Glasgow coma scale (GCS), Hunt-Hess, World Federation of Neurological Surgeons (WFNS), and modified Fisher scales, as well…
- Trial name
- SAHstdy (NCT06563219)
- Testing
- Glasgow coma scale, Hunt-Hess scale, World Federation of Neurological Surgeons (WFNS) scale
- Where
- Turkey (Türkiye)
- Volunteers
- 451 people
- Sponsor
- Haseki Training and Research Hospital
Carcinoma, Hepatocellular, Cirrhosis
Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI
The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver.
- Trial name
- PREMIUM (NCT05486572)
- Testing
- Abbreviated Magnetic Resonance Imaging with serum AFP, Abdominal Ultrasound Screening with serum AFP
- Where
- 34 sites in United States
- Volunteers
- 4,700 people
- Sponsor
- VA Office of Research and Development
Uric Acid
Uric Acid and Surgical Prognosis
Preoperative serum uric acid significantly impacted mortality and morbidity in non-cardiac surgery.
- Trial name
- NCT06837545
- Testing
- No Intervention (Observational Study)
- Where
- South Korea
- Volunteers
- 309,353 people
- Sponsor
- Asan Medical Center
Severe Burns, Acute Kidney Injury
Association of Continuous Renal Replacement Therapy With Mortality and Length of Stay in Critically Burned Patients
This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT).
- Conditions
- Severe Burns, Acute Kidney Injury, Critical Illness
- Trial name
- CRRT-BURN (NCT07195565)
- Where
- Turkey (Türkiye)
- Volunteers
- 238 people
- Sponsor
- Pinar Timur Tasci
Fragility, Cancer
Frailty Evaluation in Elderly Population With Cancer
The Comprehensive Geriatric Assessment (CGA) is, still today, barely established in the standard practice. Although the different scientific societies recommend a CGA in elderly population affected with cancer at first visit, the…
- Trial name
- ELDERLY (NCT03101631)
- Testing
- Comprehensive Geriatric Assessment (CGA)
- Volunteers
- 62 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Infection
MDR Bacilli Surveillance and Clinical Feature in China
Objective 1. To evaluate the impact of MDR pathogen on prognosis and therapy cost; 2. To compare the efficacy of different antibiotics in treatment of infection caused by MDR pathogens; 3.
- Trial name
- MDR (NCT02140853)
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Sun Yat-sen University
Mortality, Malaria
Improved Management and in-Hospital Mortality
The study intend to evaluate whether the use of standardised malaria case management protocol plus financial incentives added to the availability of free drugs reduce the case-fatality at the paediatric ward.
- Trial name
- MTV (NCT00465777)
- Testing
- Guideline adherence and financial incentive
- Where
- Guinea-Bissau
- Volunteers
- 950 people
- Sponsor
- Bandim Health Project
Atherosclerosis, Intermittent Claudication
Does the Reduction of Total Body Iron Storage (TBIS) Alter Mortality in a Population of Patients With Advanced PVD?
Veterans Affairs Cooperative Study #410, The Iron and Atherosclerosis Trial, FeAST, a 24-hospital prospective randomized single-blinded clinical trial of graded iron reduction was conducted between May 1, 1999 and April 30, 2005…
- Conditions
- Atherosclerosis, Intermittent Claudication, Peripheral Vascular Diseases
- Trial name
- FeAST (NCT00032357)
- Testing
- Ferritin reduction to 25 ng/ml by phlebotomy
- Where
- 24 sites in United States, Puerto Rico
- Volunteers
- 1,277 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Postoperative Complications After Gastrointestinal Operations
Randomized Clinical Trial: Nasoenteric Catheter or Jejunostomy
Curative treatment of upper gastrointestinal tract neoplasms is complex and associated with high morbidity and mortality. In general, the patients are already malnourished, and early postoperative enteral nutrition is…
- Trial name
- NCT01894490
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of Minas Gerais
Acute Myocardial Infarction
Mortality Analysis of ST Elevation Myocardial Infarction (STEMI) Patients in Belgium
The purpose of this observational study is to assess predictors of in-hospital mortality in patients with acute myocardial infarction admitted to Belgian hospitals.
- Trial name
- NCT00727623
- Where
- Belgium
- Volunteers
- 20,000 people
- Sponsor
- Universiteit Antwerpen
Atherosclerosis, Chronic Kidney Diseases
The ILERVAS Project: Assessing the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease
BACKGROUND AND OBJECTIVES: Cardiovascular disease is the leading cause of death despite huge primary and secondary prevention policies with a strong economic burden.
- Conditions
- Atherosclerosis, Chronic Kidney Diseases, Metabolic Syndrome, PreDiabetes
- Trial name
- ILERVAS (NCT03228459)
- Testing
- Dried blood spot test, Urine test, Artery ultrasound
- Where
- 3 sites in Spain
- Volunteers
- 16,660 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Tricuspid Regurgitation
Tricuspid RegurgitAtion rIsk modeL Study (TRAIL Study)
This study is a multicenter cohort study including patients diagnosed with tricuspid regurgitation during hospitalization. The primary outcome of the study is all-cause death, and the secondary outcome is cardiovascular events.
- Trial name
- NCT06926959
- Where
- 7 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-sen University
Telehealth Services, Telehealth
Impact of Telehealth Care
Heart failure is associated with high incidence and mortality rates, limited physical activity, decreased quality of life, and increased healthcare expenses.
- Trial name
- NCT06656520
- Sponsor
- Pei-Hung Liao
Postoperative Complications
Predictive Model for Postoperative Mortality
Surgery has risk of morbidity and mortality. Risk factors include: patient factors; surgical factors; and anesthetic factors. The risk is much higher in emergency cases.
- Trial name
- NCT02947789
- Testing
- Emergency surgery
- Where
- Thailand
- Volunteers
- 740 people
- Sponsor
- Khon Kaen University
Apparently Healthy Elderly People, (Between 60-92 Years of Age)
Association Between Mortality and Diabetes in Elderly Koreans: the South-West Seoul (SWS) Study
Diabetes mellitus is known to increase the risk of premature death in the general population. In this study, the investigators examine the impact of body mass index (BMI) levels, waist circumference, and presence/absence of…
- Trial name
- NCT01977391
- Where
- South Korea
- Volunteers
- 2,263 people, healthy volunteers welcome
- Sponsor
- Korea University