Clinical trials: Mosquito-Borne Diseases
HIV Infection, Lymphatic Filariasis
Interaction Between HIV and Lymphatic Filariasis
The impact of lymphatic filariasis (LF) on HIV is assessed by measuring HIV viral load before and after DEC treatment of filariasis in double-infected individuals.
- Trial name
- NCT00295698
- Testing
- Diethylcarbamazine
- Sponsor
- DBL -Institute for Health Research and Development
Malaria
Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated Malaria
This is a bi-centric phase IIIb, randomized, open label, 3-arm clinical trial performed to investigate the impact of retreatment with an Artemisinin-Based Combination (ACT), for example Arthemeter-Lumefantrine (AL) in Uganda (Ug)…
- Trial name
- QuinAct (NCT01374581)
- Testing
- Artemether/Lumefantrine, Artesunate/Amodiaquine, Quinine + Clindamycin
- Where
- 2 sites in Republic of the Congo, Uganda
- Volunteers
- 2,117 people
- Sponsor
- Universiteit Antwerpen
Malaria
Bioavailability Study of Oral OZ439 Prototype Formulations Administered With Piperaquine Phosphate (PQP)
A single dose study to investigate how different formulations of OZ439 co-administered with PQP tablest are processed by the body when taken without food
- Trial name
- NCT02083406
- Testing
- 800mg OZ439 prototype formulation 1, 800mg OZ439 prototype formulation 2, 800mg OZ439 prototype formulation 3
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Initial Study of Malaria Vaccine Pfs25-EPA/Alhydrogel(Registered Trademark)
Background: The malaria vaccine Pfs25-EPA/Alhydrogel may help block malaria parasites from developing in mosquitoes. When a mosquito bites a vaccinated person, the vaccine should prevent parasites from developing in the mosquito.
- Trial name
- NCT01434381
- Testing
- Pfs25-EPA/Alhydrogel
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chikungunya Virus Infection
Antibody Persistence And Long Term Safety Of A Chikungunya Virus Vaccine (VLA1553)
In this open-label Phase 3b, single arm trial, persistence of antibodies and long term safety will be evaluated in up to 375 participants rolled over from trial VLA1553-301 (NCT number: NCT04546724).
- Trial name
- NCT04838444
- Testing
- VLA1553
- Where
- 10 sites in United States
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Malaria
A Study to Evaluate the Pharmacokinetics of Oral Formulations of MMV390048 Administered Fasted to Healthy Volunteers
This study will be conducted in a single centre, as an open single dose two parallel cohorts design with oral doses of MMV390048 administered in healthy male and female subjects between 18 to 55 years of age.
- Trial name
- NCT02554799
- Testing
- MMV390048 formulation A, MMV390048 formulation B
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Rift Valley Fever
Rift Valley Fever in Kenya
The purpose of this study is to find out how, why, and when Rift Valley Fever (RVF) spreads. Participants will be 250 adults and children, aged 1 year and older, from the Ijara District, Kenya.
- Trial name
- NCT00287014
- Where
- Kenya
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Improved Clinical and Microscopy Diagnosis at Primary Health Care in Tanzania
General objective: To improve the quality of fever case management in children in government health facilities in Tanzania Hypothesis:The training of health workers, as well as provision, training and use of microscopes for…
- Trial name
- NCT00687895
- Testing
- Clinical algorithm and microscopy diagnosis of malaria
- Where
- Tanzania
- Volunteers
- 3,131 people
- Sponsor
- Muhimbili University of Health and Allied Sciences
Malaria,Falciparum, Chemoprevention
Seasonal Malaria Chemoprevention Rapid Assessment Study Mozambique
Seasonal malaria chemoprevention (SMC) is a highly effective community-based intervention to prevent malaria infections caused by Plasmodium falciparum in areas where the burden of malaria is high and malaria transmission is…
- Trial name
- NCT06337253
- Testing
- Sulfadoxine/pyrimethamine plus amodiaquine
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Congenital Zika Syndrome
Impacts of a Physical Therapy Protocol on Motor Function in Children With Congenital Zika Syndrome
The study aims to evaluate the effects of a specialized physiotherapy protocol aimed at the motor function of children with Congenital Zika Virus Syndrome.
- Trial name
- NCT06900322
- Testing
- Experimental Group (stimuli and handling; physical therapy [PediaSuit]), control group (conventional physical therapy)
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Gabriela Lopes Gama
Malaria, Malaria Vaccines
A Study Assessing the Safety, Efficacy, and Impact of GlaxoSmithKline Biologicals' RTS, S/AS01E Malaria Vaccine in Young Children Across Sub-Saharan Africa
The RTS, S/AS01E vaccine was developed to protect children in sub-Saharan Africa from malaria as part of routine immunization programs. This study aims to check the vaccine's safety after it has been introduced.
- Trial name
- EPI-MAL-003 (NCT03855995)
- Testing
- Whole blood sample
- Where
- 6 sites in Ghana, Kenya and 1 more
- Volunteers
- 77,953 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
P. Falciparum
Pregnant Women for Malaria Surveillance
Close monitoring of malaria in pregnancy can help to quickly identify changes in malaria burden and related adverse outcomes, especially in areas embarking in malaria elimination activities.
- Trial name
- MiPMon (NCT04412005)
- Testing
- No intervention
- Volunteers
- 16,958 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Malaria
Primaquine's Gametocytocidal Efficacy in Malaria Asymptomatic Carriers
In this study, the investigators are interested to know if lower doses of Primaquine together with dihydroartemisinin-piperaquine can produce a similar effect of clearing both sexual and asexual parasites in asymptomatic carriers…
- Trial name
- PRINOGAM (NCT01838902)
- Testing
- DHA-PPQ, PQ (0.75), PQ (0.4)
- Where
- The Gambia
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Plasmodium Falciparum Malaria
Efficacy of Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria.
Artemether-lumefantrine has been used in Tanzania as first-line treatment for uncomplicated malaria since 2007. Nonetheless, a report of increased proportion of patients with parasitaemia on day 1 following treatment with…
- Trial name
- ALE (NCT02089841)
- Testing
- Artemether-lumefantrine
- Where
- Tanzania
- Volunteers
- 140 people
- Sponsor
- Richard Mwaiswelo
Malaria Infection, Malaria Vaccines
Comparison of Two Strategies for Administering the R21-Matrix M Vaccine in a Context of Seasonal Malaria Transmission in Chad
This is a two-arm, cluster-randomised, phase IV trial conducted in Chad to assess the protective efficacy and impact in real-life conditions of a new strategy for administering the R21/MM malaria vaccine, synchronized within a…
- Trial name
- COSAV-R21 (NCT07038837)
- Testing
- "Synchronised" arm (intervention)
- Where
- Chad
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Epicentre
Japanese Encephalitis
Longterm Immunogenicity of the Japanese Encephalitis Vaccine IC51
The study investigates the long term safety and immunogenicity of the Japanese Encephalitis vaccine IC51 up to month 60.
- Trial name
- NCT00596102
- Testing
- Japanese Encephalitis purified inactivated vaccine
- Volunteers
- 3,258 people, healthy volunteers welcome
- Sponsor
- Valneva Austria GmbH
Dengue Fever
Bridging Economics and Public Trust: A Study of Dengue Vaccine Cost-effectiveness and Acceptance in Thais Visiting Hospital
Study 1: Cost-effectiveness of TAK-003 Dengue Vaccination in Thailand This study aims to evaluate the cost-effectiveness of introducing the live-attenuated tetravalent dengue vaccine (TAK-003) into Thailand's national…
- Trial name
- NCT07759596
- Testing
- Objective 1- economic evaluation of Thai children with dengue vaccine
- Where
- Thailand
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dengue Fever
A Study of 2 Doses of Tetravalent Dengue Vaccine (TDV) in Infants and Toddlers
Dengue fever is caused by an infection with the dengue virus. Vaccination with Dengue Tetravalent Vaccine (TDV) can help prevent dengue fever.
- Trial name
- NCT06665035
- Testing
- TDV
- Where
- 4 sites in Colombia, Thailand
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Takeda
Vivax Malaria
Study of ACTs Plus Primaquine for Uncomplicated Plasmodium Vivax Malaria
This randomized clinical trial will be conducted in subjects with uncomplicated Plasmodium vivax malaria during November 2010 to March 2012.
- Trial name
- ACTPQ (NCT01288820)
- Testing
- Dihydroartemisinin/piperaquine + primaquine, Artesunate-amodiaquine + primaquine
- Where
- Indonesia
- Volunteers
- 331 people
- Sponsor
- University of Oxford
Malaria, Cerebral
DON in Pediatric Cerebral Malaria
The goal of this clinical trial is to evaluate the safety of a single intravenous dose of DON in healthy adults, adults with uncomplicated malaria, and children 12 months-14 years old with clinically defined Cerebral Malaria.
- Trial name
- NCT05478720
- Testing
- 6-diazo-5-oxo-L-norleucine (DON)
- Where
- 2 sites in Malawi
- Volunteers
- 152 people
- Sponsor
- Douglas Postels, MD, MS
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.