Clinical trials: Mosquito-Borne Diseases
Malaria
Perennial Malaria Chemoprevention (PMC) Effect Study
The Malaria Consortium Nigeria (MC) will coordinate a trial of PMC in Osun State, Nigeria with strategic support from the National Malaria Elimination Programme of the Government of Nigeria (NMEP) and financial support from the…
- Trial name
- PMCEffect (NCT06155448)
- Testing
- Perennial Malaria Chemoprevention effect
- Where
- Nigeria
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium
Alpha and Beta Thalassemia, Sickle Cell Disease
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
Background: Blood disorders like sickle cell disease and malaria affect many people around the world. Researchers want to learn more about blood disorders.
- Conditions
- Alpha and Beta Thalassemia, Sickle Cell Disease, Malaria, Human Physiology
- Trial name
- NCT03937817
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Safety and Protective Efficacy of IV Immunization With Cryopreserved PfSPZ Under A/P Chemoprophylaxis
Single center, randomized, placebo-controlled, double-blinded trial using PfSPZ Challenge (NF54) under A/P chemoprophylaxis for immunization and PfSPZ Challenge (NF54) and PfSPZ Challenge (7G8) for repeat CHMI.
- Trial name
- NCT02858817
- Testing
- atovaquone/proguanil 250mg/100mg (A/P), PfSPZ Challenge (NF54), NaCl 0,9%
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Malaria
First-in-Human PfSPZ-LARC2 Vaccination/CHMI
This randomized, double-blind, placebo-controlled, Phase 1 trial will enroll up to 22 malaria-naïve, adult participants to test safety, tolerability, immunogenicity, and efficacy of the genetically attenuated Plasmodium…
- Trial name
- NCT06735209
- Testing
- PfSPZ Vaccine, PfSPZ (7G8) Challenge, Sodium Chloride, 0.9%
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dengue Fever, Dengue Hemorrhagic Fever
Immunogenicity and Safety of a Tetravalent Dengue Vaccine Booster Injection in Subjects Who Previously Completed a 3-dose Schedule
The aim of the study was to assess and describe the booster effect of a tetravalent CYD dengue vaccine dose administered about 5 years or more after the completion of a 3-dose vaccination schedule in Singapore.
- Trial name
- NCT02824198
- Testing
- CYD Dengue Vaccine (5 dose formulation)
- Where
- 3 sites in Singapore
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Malaria
Clinical Trial for Malaria Vaccines to Test for Safety, Immune Response and Protection Against Malaria
The purpose of this study is to test the safety and effectiveness of a new malaria vaccine, the DNA-Ad vaccine. The study is specifically looking at a vaccine regimen against Plasmodium falciparum, the most deadly form of malaria.
- Trial name
- DNA-Ad (NCT00870987)
- Testing
- DNA vaccine prime, adenovirus type 5 vaccine boost
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Fever, Malaria
Use of Malaria Rapid Diagnostic Tests as a Decision Aid for the Management of Fever by International Travelers
This study is part of a larger prospective cohort study (JOKA), designed to study the incidence and etiological spectrum of febrile illness occurring during a travel to the tropics, as well as clinical course, care, treatment and…
- Trial name
- JOKA-I (NCT02900079)
- Testing
- rapid diagnostic test for malaria antigen
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites in Healthy African Adults in Mali
Background: Malaria is still a health problem in Sub-Saharan Africa. Death rates are stable and have even increased in some areas. There are malaria vaccines.
- Trial name
- NCT02627456
- Testing
- PfSPZ Vaccine, PfSPZ Challenge Material, PBS and HSA Diluent
- Where
- Mali
- Volunteers
- 409 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Japanese Encephalitis
Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis
Japanese encephalitis is caused by a viral infection of the brain transmitted by the bite of an infected mosquito. Patients with Japanese encephalitis can rapidly develop worsening conscious level and seizures.
- Trial name
- NCT01856205
- Testing
- Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
- Where
- 2 sites in Nepal
- Volunteers
- 22 people
- Sponsor
- University of Liverpool
Malaria
Weekly Dosing of Malarone ® for Prevention of Malaria
The purpose of this study is to determine whether Malarone ®, which is a drug approved to prevent malaria when taken daily, will still effectively prevent malaria if taken weekly.
- Trial name
- MALWEEK (NCT00984256)
- Testing
- Atovaquone Proguanil, Procedure - malaria challenge
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria, Falciparum
Safety and Immunogenicity of Recombinant Pichia Pastoris AMA1-DiCo Candidate Malaria Vaccine With GLA-SE and Alhydrogel ® as Adjuvant in Healthy Malaria Non-Exposed European and Malaria Exposed African Adults
The primary objective is to evaluate the safety of 3 doses given at D0, W4, and W26 of 50 µg dosage of AMA1-DiCo adjuvanted either with GLA-SE or Alhydrogel® in healthy European adults not previously exposed to the parasite…
- Trial name
- AMA1-DiCo (NCT02014727)
- Testing
- Group A1 : 50µg AMA1-DiCo + Alhydrogel, Group A2 : 50 µg AMA1-DiCo+ GLA-SE
- Where
- 2 sites in Burkina Faso, France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Malaria
Stimulating Private Sector Malaria Control
Preliminary evidence from ongoing research provides strong indications that protecting farmers from malaria would be profitable for outgrowing agribusinesses in sub-Saharan Africa.
- Trial name
- Outgrowers (NCT01397851)
- Testing
- Insecticide-treated net (BASF Incerceptor)
- Where
- Zambia
- Volunteers
- 81,597 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria
Assessment of Biologic Parameters in Preparation for Future Malaria Vaccine Trials in Don gu Bougou, Mali
There are about 300-500 million cases of malaria worldwide each year, with 2-3 million deaths. Plasmodium falciparum, one of four types of malaria, is responsible for most of these deaths.
- Trial name
- NCT00341783
- Where
- United States
- Volunteers
- 515 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Severe Malaria
Monoclonal Antibodies in Children With Severe Anaemia or Severe Malaria to Prevent Malaria After Hospital Discharge
Background and rationale: Hospitalised children with severe anaemia remain at high risk of dying or requiring hospital readmission for at least 6 months after discharge.
- Conditions
- Malaria, Severe Malaria, Severe Anaemia, Post Discharge
- Trial name
- L9LS-pd (NCT07082205)
- Testing
- Antimalarial monoclonal antibodies, Dihydroartemisinin - Piperaquine (DP)
- Where
- 2 sites in Kenya
- Volunteers
- 398 people
- Sponsor
- Liverpool School of Tropical Medicine
Tropical Disease
A Pilot Study Examining for the Presence of Fecal Coliforms and Tropical Diseases in Peru
Tropical diseases are continuously on the rise throughout the world as they are spreading and manifesting in various locations globally.
- Trial name
- NCT03078894
- Testing
- Zika, Chikagunya, Dengue
- Where
- 4 sites in Peru
- Volunteers
- 100 people
- Sponsor
- BioRed LLC
Dengue, Dengue With Warning Signs
Effect of Montelukast in Preventing Dengue With Warning Signs in Dengue Patients
This study aims to determine the efficacy of montelukast in reducing the incidence of dengue warning signs in adult dengue patients.
- Conditions
- Dengue, Dengue With Warning Signs, Dengue Shock Syndrome
- Trial name
- NCT04673422
- Testing
- Montelukast
- Where
- 4 sites in Thailand
- Volunteers
- 358 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Malaria, Falciparum, Hookworm Infections
Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
- Conditions
- Malaria, Falciparum, Hookworm Infections, Schistosoma Haematobium
- Trial name
- NCT01163877
- Testing
- Fe-57 orally, Fe-58 intravenously
- Where
- Côte d’Ivoire
- Volunteers
- 43 people
- Sponsor
- Swiss Federal Institute of Technology
Malaria in Pregnancy, HIV Infections
Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine
The purpose of this study is to evaluate the efficacy of cotrimoxazole prophylaxis in prevention of malaria during pregnancy in HIV-infected women, compared to intermittent preventive treatment with mefloquine.
- Trial name
- PACOME (NCT00970879)
- Testing
- cotrimoxazole, mefloquine
- Where
- 5 sites in Benin
- Volunteers
- 430 people
- Sponsor
- Institut de Recherche pour le Developpement
Japanese Encephalitis
Treatment of Japanese Encephalitis
Japanese encephalitis is the single largest cause of viral encephalitis in the world today. It occurs in yearly post monsoon outbreaks in Uttar Pradesh and other parts of India and south east Asia.
- Trial name
- NCT00216268
- Testing
- Ribavirin
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Indian Council of Medical Research
Malaria, Malaria Prophylaxis
Boosting the Impact of SMC Through Simultaneous Screening and Treatment of Roommates
Malaria represents a major public health concern in sub-Sahara Africa. Seasonal malaria chemoprevention (SMC) is one of the largest preventive measures.
- Conditions
- Malaria, Malaria Prophylaxis, Mass Testing and Treatment
- Trial name
- SMC-RST (NCT04816461)
- Testing
- Amodiaquine Sulfadoxine-Pyrimethamin administration, Dihydroartemisinin-Piperaquine, Standard HRP2-RDT
- Where
- Burkina Faso
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso