Clinical trials: Mosquito-Borne Diseases
Fever, Malaria
Use of Malaria Rapid Diagnostic Tests as a Decision Aid for the Management of Fever by International Travelers
This study is part of a larger prospective cohort study (JOKA), designed to study the incidence and etiological spectrum of febrile illness occurring during a travel to the tropics, as well as clinical course, care, treatment and…
- Trial name
- JOKA-I (NCT02900079)
- Testing
- rapid diagnostic test for malaria antigen
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Malaria
Artemisinin Resistance in Bangladesh
A randomized, controlled clinical trial conducted in Southeastern Bangladesh using artesunate monotherapy to determine the baseline sensitivity of P. falciparum to artemisinins.
- Trial name
- NCT00639873
- Testing
- Artesunate, quinine-doxycycline
- Where
- Bangladesh
- Volunteers
- 126 people
- Sponsor
- Medical University of Vienna
Malaria
Dihydroartemisinin (DHA)-Piperaquine for IPT to Prevent Malaria in Children in Burkina Faso
The aim of the study is to determine whether piperaquine plus dihydroartemisinin (DHA-PQ) is as effective, and better tolerated, than sulfadoxine-pyrimethamine plus amodiaquine (SP+AQ), when used for seasonal Intermittent…
- Trial name
- NCT00941785
- Testing
- DHA-PQ, SP-AQ
- Where
- Burkina Faso
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria,Falciparum, Malaria
Efficacy, Effect on Gametocytes and Tolerability of the Addition of Artesunate to Amodiaquine in Colombia
The primary goal of this study is to quantify the benefit of adding artesunate to amodiaquine in treating patients with uncomplicated P. falciparum malaria, in a low transmission area in Colombia.
- Conditions
- Malaria,Falciparum, Malaria, Antimalarials
- Trial name
- NCT00378625
- Testing
- Artesunate
- Where
- Colombia
- Volunteers
- 360 people
- Sponsor
- Centro Internacional de Entrenamiento e Investigaciones Médicas
Lymphatic Filariasis
Efficacy of Higher Albendazole and Ivermectin Doses on Wuchereria Bancrofti Microfilarial Clearance in Malawi
Albendazole and ivermectin are currently used in combination for annual mass treatment of lymphatic filariasis in Africa. Although the drugs have been donated, the cost of such programmes is very high and has proven to be a major…
- Trial name
- FED (NCT01213576)
- Testing
- Albendazole 400mg and ivermectin 200mcg/kg, Albendazole and ivermectin, albendazole 800mg and ivermectin 400mcg/kg bi-annually
- Where
- Malawi
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections, Malaria
The Effect of Malaria on Disease Progression of HIV/AIDS
The purpose of this study is to find out whether malaria affects how HIV/AIDS disease progresses in an infected patient, and to determine the effect of reducing malaria infection on HIV disease progression in Kumasi
- Trial name
- NCT00499876
- Testing
- mefloquine
- Where
- Ghana
- Volunteers
- 197 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Evaluation of Vector and Chemoprevention-based Interventions to Reduce Malaria Burden in Urban Daaras of Touba, Senegal
This study aims to evaluate the effectiveness of the use of adapted insecticide-treated mosquito nets combined with extended DHA-PQ-based seasonal chemoprevention for all ages and behavior change communication in reducing the…
- Trial name
- NCT06225297
- Testing
- Intervention package
- Where
- Senegal
- Volunteers
- 4,600 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria
A Trial on Supervised Primaquine Use in Ethiopia
This is a randomized, controlled, open label trial to assess the effectiveness of unsupervised versus supervised primaquine treatment in patients with uncomplicated malaria. In co-endemic regions, the risk of P.
- Trial name
- SPRUE (NCT02793388)
- Testing
- Supervised primaquine treatment, Unsupervised primaquine treatment
- Sponsor
- Menzies School of Health Research
Plasmodium Falciparum, Plasmodium Vivax
The Malaria Heart Disease Study
The Malaria Heart Disease Study is a prospective longitudinal cohort study of a random sample of approximately 1200 individuals from the state of Acre in Brazil.
- Conditions
- Plasmodium Falciparum, Plasmodium Vivax, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT04445103
- Testing
- Assessment of cardiac function
- Where
- Brazil
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Malaria
Pfs230D1M-EPA/AS01 Vaccine, a Transmission Blocking Vaccine Against Plasmodium Falciparum, in an Age De-Escalation Trial of Children and a Family Compound Trial in Mali
Background: Malaria affects many people in Mali and other parts of Africa. It is spread by mosquito bites. Malaria can make people sick or can lead to death.
- Trial name
- NCT03917654
- Testing
- Pfs230D1M-EPA/AS01, HAVRIX, TYPHIM Vi (Salmonella typhi vaccine)
- Where
- Mali
- Volunteers
- 1,301 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
ATAQ EASY: Artesunate + Amodiaquine Fixed Dose Combination in the Treatment of Uncomplicated Plasmodium Falciparum Malaria
Primary Objective: To demonstrate the non-inferiority, in terms of clinical and parasitological efficacy on D28 of administration of Coarsucam™ (artesunate+amodiaquine fixed-dose combination), as a single daily dose, in…
- Trial name
- NCT00316329
- Testing
- Artesunate + Amodiaquine
- Where
- 5 sites in Cameroon, Madagascar and 2 more
- Volunteers
- 1,032 people
- Sponsor
- Sanofi
Malaria
Safety, Tolerability and Efficacy of PfSPZ Vaccine in Healthy Children and Infants 5 Months - 9 Years Living in Kenya
This study will be conducted in Siaya County in Nyanza Province, western Kenya. Healthy children aged 5 months through 9 years of age living within approximately 10 km of the study clinic(s) (Siaya County Referral Hospital, or…
- Trial name
- NCT02687373
- Testing
- PfSPZ Vaccine, Normal Saline
- Where
- Kenya
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Plasmodium Falciparum Infection
PfSPZ Challenge in Non-immune Adults in Baltimore, USA
This is a single center, randomized and controlled human study to optimize controlled human malaria infection (CHMI) administered by direct venous inoculation (DVI).
- Trial name
- NCT02780154
- Testing
- PfSPZ (7G8) Challenge, PfSPZ (NF54) Challenge
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malnutrition, Malaria
Effectiveness of Nutritional Supplementation in Preventing Malnutrition in Children With Infection
The purpose of this study is to determine whether 14 days nutritional supplementation with Ready to use therapeutic Food (RUTF) or micronutrients alone to children having an infection will prevent malnutrition and reduce the…
- Conditions
- Malnutrition, Malaria, Lower Respiratory Tract Infection, Diarrhoea
- Trial name
- NCT01154803
- Testing
- Ready to Use Therapeutic Food (RUTF), Micronutrient Powder (MNP)
- Where
- Nigeria
- Volunteers
- 2,213 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Malaria, Falciparum, Plasmodium Falciparum
Clinical Practices for Treating Severe Malaria Caused by P. Falciparum
This study looks at how doctors in three hospitals in France treat patients with a serious form of malaria caused by Plasmodium falciparum. It focuses on cases where the level of malaria parasites in the blood is 4% or higher.
- Conditions
- Malaria, Falciparum, Plasmodium Falciparum, Antimalarials, Artemisinins
- Trial name
- NCT07027722
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Healthy
DSM265 Prophylaxis of Plasmodium Falciparum Malaria
The study is a single centre, randomised, placebo-controlled, double-blind study with DSM265 including up to two cohorts of healthy male and female volunteers aged 18 to 45 years.
- Trial name
- NCT02562872
- Testing
- DSM265, Sporozoites, Infective mosquito bite
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Modifying Immunity in Children With DihydROartemisinin-Piperaquine (MIC-DroP)
The MIC-DroP trial will test the hypothesis that preventing early life blood-stage malaria antigenic exposure with intermittent preventive therapy (IPT) enhances protective immunity to malaria.
- Trial name
- MIC-DroP (NCT04978272)
- Testing
- Dihydroartemisinin-piperaquine (DP)
- Where
- Uganda
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Grant Dorsey, M.D, Ph.D.
Malaria,Falciparum, Anemia in Children
Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine (IPT-DP).
- Trial name
- NCT06083688
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine, Sulfadoxine-pyrimethamine-amodiaquine
- Where
- Malawi
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Malaria, Vivax
Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malaria
Tafenoquine (TQ) is an 8-aminoquinoline anti-malarial drug which is in development as a single-dose treatment for the radical cure of P.vivax malaria when given with standard doses of chloroquine.
- Trial name
- NCT02802501
- Testing
- Tafenoquine, Primaquine, Dihydroartemisinin-piperaquine (DHA-PQP)
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- GlaxoSmithKline
Malaria, Pyelonephritis
Contrast-Enhanced US of Spleen, Liver and Kidney
To evaluate the changes in the microcirculation of the liver, kidney and spleen during acute infection in patients with malaria (cohorts 1 and 3) and other infectious diseases such as acute pyelonephritis at day 0 (within 8 hours…
- Conditions
- Malaria, Pyelonephritis, Bacterial Infections
- Trial name
- NCT00190281
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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