Clinical trials: Mosquito-Borne Diseases
Lymphatic Filariasis
Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa
This study will determine if a combination of 3 drugs used to treat the infection that cause lymphatic filariasis (LF) due to Wuchereria bancrofti infection are more effective in killing or sterilizing the adult worms compared to…
- Trial name
- NCT01975441
- Testing
- Diethylcarbamazine, Albendazole, Ivermectin
- Where
- Papua New Guinea
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Malaria,Falciparum
Pharmacokinetics of Antimalarials in Breastfeeding Ugandan Mother-infant Pairs
Lactating women requiring treatment for uncomplicated malaria will be identified and invited for sampling. The decision to treat them with first-line treatment will have been made by the clinician, not by a member of the study…
- Trial name
- MILK Malaria (NCT05676645)
- Testing
- Artemether-lumefantrine
- Where
- Uganda
- Volunteers
- 30 people
- Sponsor
- University of Liverpool
Plasmodium Falciparum Malaria
Human Immunity to MSP-1 in Western Kenya
This is a study of 125 healthy male and female Kenyan adults aged 18 years and above, and 300 healthy male and female Kenyan infants enrolled at 1 month of age and followed to 3 years of age.
- Trial name
- NCT00138372
- Where
- Kenya
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Malaria, Falciparum
Drug-Interaction Assessment of GSK3772701 in Healthy Male and Female Participants Aged 18 to 55 Years
This study aims to evaluate whether GSK3772701 alters the pharmacokinetics (PK) of midazolam (MDZ), a standard probe substrate for the CYP3A4 enzyme.
- Trial name
- NCT07670377
- Testing
- Midazolam (MDZ), GSK3772701
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Plasmodium Falciparum
Comparison of Arterolane-piperaquine Versus Arterolane-piperaquine+Mefloquine Versus Artemether-lumefantrine in Kenyan Children
This open-label randomised controlled clinical trial will compare the safety, tolerability, therapeutic efficacy and pharmacokinetics and pharmacodynamics of arterolane-piperaquine, arterolane-piperaquine plus mefloquine versus…
- Trial name
- TACTKenya (NCT03452475)
- Testing
- Arterolane-piperaquine, Arterolane-piperaquine+mefloquine, Artemether-lumefantrine
- Where
- Kenya
- Volunteers
- 219 people
- Sponsor
- University of Oxford
Falciparum Malaria
Tracking Resistance to Artemisinin (TRAC)
Because the artemisinins are the most potent antimalarial drugs, the reduction in parasite numbers is rapid. Therefore, early measures of reducing parasite counts are needed.
- Trial name
- TRAC (NCT01350856)
- Testing
- Artesunate 2, Artesunate 4
- Where
- 19 sites in Bangladesh, Burma and 8 more
- Volunteers
- 1,700 people
- Sponsor
- University of Oxford
Malaria, Bacterial Infections
Trial of Rapid Diagnostic Tests in Rural Ghana
1) To compare in a setting where microscopy for malaria is available whether introducing rapid diagnostic tests (RDTs) improves targetting of antimalarial drugs and antibiotics (RDT v microscopy).
- Trial name
- RDT (NCT00493922)
- Testing
- Rapid diagnostic test, Microscopy, Clinical diagnosis for malaria
- Where
- Ghana
- Volunteers
- 7,263 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
MMV390048 POC in Patients With P. Vivax and P. Falciparum Malaria
The present proof-of-concept Phase IIa study aims to confirm, in patients, the observed activity of MMV390048 against P. falciparum in pre-clinical models and the human Induced Blood-Stage Malaria (IBSM) challenge model, and to…
- Trial name
- NCT02880241
- Testing
- MMV390048
- Where
- 2 sites in Ethiopia
- Volunteers
- 8 people
- Sponsor
- Medicines for Malaria Venture
Dengue
ADVP005; Dengue CVD 12000 - Dengue-1-Virus Live Virus Human Challenge (DENV-1-LVHC)
The purpose of this research study is to test the protection of volunteers previously vaccinated with Tetravalent Dengue Virus (TDEN) Purified Inactivated Vaccine (PIV) with alum and boosted with TDEN live attenuated vaccine…
- Trial name
- NCT04786457
- Testing
- Dengue 1 Live Virus Human Challenge (DENV-1-LVHC)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Day-3 Positive of Parasitaemia, Prevalence of Drug Resistance Gene Mutation
Molecular Assessment of Artemisinin Resistance Markers in Eastern and Western Border Areas of Myanmar
Artemisinin resistance have been documented in Myanmar and Myanmar artemisinin resistance containment measures have been launched since 2009-2010.
- Trial name
- NCT02198573
- Where
- Burma
- Volunteers
- 91 people
- Sponsor
- Myat Htut Nyunt
Malaria, Diabetes Mellitus
Diabetes, Metabolic Syndrome and Risk of Malaria in Cameroon
Non-communicable diseases (NCDs) such as diabetes are increasing in countries where malaria transmission is common. This study aims to investigate the relationship between NCDs and parasitic infections in Cameroon.
- Conditions
- Malaria, Diabetes Mellitus, Metabolic Syndrome, Endemic
- Trial name
- NCT06278181
- Where
- Cameroon
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Malaria
Trial of Artemether-Lumefantrine Alone and in Combination With Ivermectin to Reduce Post-Treatment Malaria Transmission
The purpose of this study is to determine the safety and impact of ivermectin, administered as single or repeated dose, in combination with artemether-lumefantrine in reducing the proportion of mosquitoes that survive and become…
- Trial name
- ACTIVE (NCT01603251)
- Testing
- Artemether-lumefantrine combination, Artemether-lumefantrine combination + single dose Ivermectin, Artemether-lumefantrine combination + repeated dose Ivermectin
- Where
- Burkina Faso
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Fever
Cluster Randomised Trial of Malaria RDTs Used by CHWs in Afghanistan
Malaria is a common, but decreasing, cause of fever in endemic areas. The use of rapid diagnostic tests could improve treatment of malaria at the local community level. Deployment of these tests is, however, a considerable cost.
- Conditions
- Malaria, Fever, Acute Febrile Illness, Pneumonia
- Trial name
- NCT01403350
- Testing
- Malaria Rapid Diagnostic test
- Where
- 3 sites in Afghanistan
- Volunteers
- 2,421 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
A Trial of Intermittent Treatment in the Prevention of Malaria in Senegalese Children
In countries of the Sahel and sub-Sahel, malaria transmission is highly seasonal with nearly all infections occurring during a few months of the year.
- Trial name
- NCT00132561
- Testing
- Sulfadoxine/pyrimethamine and artesunate
- Where
- Senegal
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Effectiveness of Artemether-Lumefantrine for Malaria Treatment of Children at Community Level in Tanzania
The purpose of this clinical trial is to assess the effectiveness of artemether-lumefantrine (Coartem®) treatment provided by community health workers against uncomplicated malaria in children under 5 years of age in Kibaha…
- Trial name
- C3 (NCT00454961)
- Testing
- artemether-lumefantrine
- Where
- Tanzania
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital
Malaria
LLIN Evaluation in Uganda Project
In Uganda, the National Malaria Control Division (NMCD) and implementing partners plan to deliver long-lasting insecticidal nets (LLINs) nationwide in 2020-21, through a mass distribution campaign supported by generous…
- Trial name
- LLINEUP2 (NCT04566510)
- Testing
- long lasting insecticidal nets with alpha-cypermethrin + pyriproxyfen (PPF LLIN, Royal Guard)), long lasting insecticidal nets with deltamethrin + piperonyl butoxide (PBO LLIN, PermaNet 3.0)), Social behaviour change communication
- Where
- Uganda
- Volunteers
- 32,895 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
EaveTubes for Vector Control
The goal of this clinical trial is to test whether In2Care EaveTubes (ETs) as a stand-alone tool can reduce malaria in an area where transmission is driven by insecticide-resistant Anopheles gambiae.
- Trial name
- NCT05736679
- Testing
- In2Care EaveTube
- Where
- Côte d’Ivoire
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Dengue, Severe Dengue
Dengue Effectiveness Study in the Philippines
This is an observational study that aims to determine the effectiveness of a tetravalent dengue vaccine (CYD-TDV) when given through a community-based immunization program against hospitalized and /or severe virologically…
- Conditions
- Dengue, Severe Dengue, Virologically Confirmed Dengue
- Trial name
- NCT03803618
- Where
- 4 sites in Philippines
- Volunteers
- 2,081 people, healthy volunteers welcome
- Sponsor
- University of the Philippines
Malaria
Evaluation of Rapid Diagnosis Tests in Imported Malaria
The annual number of cases of clinical malaria worldwide is estimated to be 300-500 million leading to 1.5 million deaths. Delayed care and frequent drug resistance of Plasmodium falciparum (Pf), the most frequent form of…
- Trial name
- TDR-PALU (NCT00451269)
- Testing
- Rapid diagnosis test for malaria
- Where
- France
- Volunteers
- 1,297 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Malaria
Efficacy, Safety, Tolerability and Pharmacokinetics of KAF156 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection
This study will assess efficacy, safety , tolerability and PK in uncomplicated adult malaria patients with P. vivax or P. falciparum infection after 3 day dosing with KAF156 at 400 mg/day (Part 1) and single dosing with KAF156 at…
- Trial name
- NCT01753323
- Testing
- KAF156
- Where
- 5 sites in Thailand, Vietnam
- Volunteers
- 43 people
- Sponsor
- Novartis Pharmaceuticals
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