Clinical trials: Mother
Maternal-Fetal KIR-HLA-C Compatibility
PREDICTIVE IMMUNOLOGICAL STUDY OF RECURRENT ABORTIONS AND IMPLANTATION FAILURE
The involvement of the immune system in the process of implantation and its modulation as a therapeutic line in these alterations, failure of implantation and repetition abortion are controversial and make it necessary to conduct…
- Trial name
- NCT04052438
- Testing
- HLA-C and KIR determination for patients, couples, oocyte or semen donors, abortive tissue and newborn.
- Volunteers
- 200 people
- Sponsor
- IVI Madrid
Obesity
The Effect of Obesity on Pregnancy and Fetal Outcome in Glucose Tolerant Mothers
The participants are divided into subjects or controls based on the BMI taken during the first trimester of pregnancy upon recruitment.
- Trial name
- NCT04116268
- Where
- Malaysia
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University Malaysia Sarawak
HIV Infections
Reducing the Incidence of Nevirapine Resistance Mutations in Pregnant HIV Infected Women Who Receive Anti-HIV Drugs Prior to and After Giving Birth
The purpose of this study is to determine which of 3 different anti-HIV drug regimens given to HIV infected pregnant women during and after their pregnancies is most effective in reducing the incidence of nevirapine (NVP)…
- Trial name
- NCT00109590
- Testing
- Didanosine, enteric-coated, Lopinavir/ritonavir, Nevirapine
- Where
- 7 sites in Thailand
- Volunteers
- 175 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Low-Birth-Weight
Formative Research to Develop an Intervention Package to Promote Practice of Kangaroo Mother Care for Low Birth Weight and Preterm Infants in a Community (CKMC)
The study is being conducted to develop an intervention to assess the feasibility of implementing Kangaroo Mother Care (KMC) for low birth weight (LBW) and preterm babies in a community setting.
- Trial name
- CKMC (NCT02613624)
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Infertility
Mitochondrial Activity of Cumulus Cells From the Cumulus-oocyte Complex and Oocyte Competence
The need for non-invasive biomarkers of oocyte competency has become urgent as women increasingly delay attempts at childbearing.
- Trial name
- NCT02793752
- Testing
- Age
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
High Risk for HIV
Zambia SiVET MMR Tdap-IPV
Participants will receive vaccination for measles, mumps, and rubella (MMR) and tetanus, diphtheria, pertussis, and inactivated polio (Tdap-IPV).
- Trial name
- SiVET (NCT02589678)
- Testing
- Tdap - IPV Vaccine, MMR Vaccine
- Where
- 2 sites in Zambia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Emory University
Environmental Enteric Dysfunction (EED)
Maternal Probiotic Intervention to Improve Gut Health - Trial II - Burkina Faso (MPIGH-II)
Burden: Environmental Enteric Dysfunction (EED) is an enteropathic condition characterized by altered gut permeability, infiltration of immune cells and changes in villous architecture and cell differentiation.
- Trial name
- MPIGH-II (NCT07134790)
- Testing
- VE818, Oral Vancomycin
- Where
- Burkina Faso
- Volunteers
- 144 people
- Sponsor
- University Ghent
Hypertension
Congenital Malformations and Maternal Use of Anti-hypertensive Medication in the United Kingdom
Assess Fetal Mortality and Malformations in Women treated with antihypertensive medication during preganancy. Mother - Child pairs will be analysed in a cohort selected from the UK in the CPRD database.
- Trial name
- NCT02459990
- Where
- United Kingdom
- Volunteers
- 22,000 people
- Sponsor
- AstraZeneca
Cytomegalovirus Infection
Efficacy Study of Human Cytomegalovirus (HCMV) Hyperimmune Globulin to Prevent Congenital HCMV Infection
The aim of this trial is to verify, under controlled conditions, the reported efficacy of human cytomegalovirus (HCMV)-specific hyperimmune globulin administration to pregnant women suffering from primary HCMV infection for the…
- Trial name
- CHIP (NCT00881517)
- Testing
- HCMV-specific hyperimmune globulin (Cytotect®)
- Where
- 11 sites in Italy
- Volunteers
- 124 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Food Insecurity, Maternal Psychological Distress
Relationship Between Food Insecurity and Child Dental Behavior
identifying children with dental uncooperative behavior among those who suffered from food insecurity will enable to implement preventive strategies and early intervention.
- Conditions
- Food Insecurity, Maternal Psychological Distress, Child Dental Behavior
- Trial name
- FI (NCT04186689)
- Testing
- Routine Dental Examination
- Where
- Egypt
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- dina darwish
Acquired Immunodeficiency Syndrome, Disease Transmission, Vertical
Anti-HIV Immunoglobulin (HIVIG) in Prevention of Maternal-Fetal HIV Transmission (Pediatric ACTG Protocol 185)
To determine if HIV hyperimmune globulin (HIVIG) given to HIV-positive pregnant women during the second and third trimester of pregnancy reduced the likelihood of maternal-fetal HIV transmission.
- Conditions
- Acquired Immunodeficiency Syndrome, Disease Transmission, Vertical, HIV Infections
- Trial name
- NCT00000590
- Testing
- immunoglobulins
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aneuploidy, NIPT
A Safer Pre-Natal Diagnosis Using Free DNA in Maternal Blood
A diagnostic peripheral maternal blood test taken and the free foetal DNA is analysed and the presence of trisomies using a novel method.
- Trial name
- IONA (NCT01472523)
- Where
- United Kingdom
- Volunteers
- 1,632 people
- Sponsor
- Premaitha Health
Placenta Accreta Spectrum, Placenta Previa
Maternal Serum Adropin in Placenta Accreta Spectrum
Aim: To compare maternal serum adropin levels in pregnancies complicated by placenta previa and/or placenta accreta spectrum (PAS) with those of healthy pregnant women and to evaluate the diagnostic value of adropin for…
- Trial name
- Adropin (NCT07421180)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Adana City Training and Research Hospital
Obesity, Water; Lack of
Preventing Early Childhood Obesity, Part 1: Family Spirit Nurture, 3-9 Months
This study aims to assess the impact of a brief home-visiting module, called "Family Spirit Nurture" (FSN), on American Indian (AI) parent feeding practices associated with increased risk for early childhood obesity, with a…
- Conditions
- Obesity, Water; Lack of, Breast Feeding, Tooth Erosion
- Trial name
- NCT03101943
- Testing
- Family Spirit Nurture (FSN), Control Program, Water Delivery
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Post Partum Depression
Sensing Technologies for Maternal Depression Treatment in Low-Resource Settings
In certain low- and middle- income country settings, there is a disproportionate level of untreated postpartum depression that presents both acute and long-term risks to a mother's well-being.
- Trial name
- StandStrong (NCT06253676)
- Testing
- Problem Management Plus (PM+)
- Where
- Nepal
- Volunteers
- 121 people
- Sponsor
- George Washington University
Maternal Health
The Impact of Non-monetary Incentives on Facility Delivery in Rural Zambia
This study measured the impact and cost-effectiveness of a low-cost, non-monetary incentive ("mama kit") on rural facility delivery rates in Zambia.
- Trial name
- NCT02517008
- Testing
- Mama kit
- Volunteers
- 2,159 people, healthy volunteers welcome
- Sponsor
- IDinsight
Post Partum Depression
Video-Feedback Interaction Guidance for Improving Interactions Between Depressed Mothers and Their Infants ("VID-KIDS")
Postpartum depression (PPD) is a major public health issue. Known as "the thief that steals motherhood" since symptoms obstruct a mother's capacity for understanding and enjoying her baby, PPD affects approximately 1 in 5 moms.
- Trial name
- VID-KIDS (NCT03052374)
- Testing
- VID-KIDS Intervention Program
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University of Calgary
Trisomy 21, Trisomy 18
Prenatal Screening for Down Syndrome With DNAFirst
This study will explore how maternal plasma circulating cell free DNA (ccfDNA) can be used as a primary screening test for Down syndrome as part of routine clinical care in the general pregnancy population.
- Conditions
- Trisomy 21, Trisomy 18, Trisomy 13, Monosomy X
- Trial name
- DNAFirst (NCT01966991)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Breastfeeding, Attachment
Promoting Mother-baby Bonding Through Sustainable Breastfeeding Practices
This research aimed to identify sustainable breastfeeding practices and green mothers' initiatives to develop a strong mother-child bond.
- Trial name
- NCT06781190
- Testing
- Green motherhood education
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Maternal Sepsis, Infections
EnCoRe MoMS: Engaging Communities to Reduce Morbidity From Maternal Sepsis (Aim 2)
Sepsis is the second leading cause of maternal death in the U.S. For racial and ethnic minoritized birthing people, especially those who are Black, living in poverty, and from underserved communities, labor and postpartum are…
- Trial name
- NCT06148532
- Where
- United States
- Volunteers
- 400,000 people
- Sponsor
- Columbia University
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