Clinical trials: Mother
Breastfeeding, Bottle Feeding
Breast Versus Bottle Study
The objective of the proposed research is to conduct a within-subject experimental study that will assess the effect of feeding mode (breast- versus bottle-feeding) on the quality and outcome of infant feeding interactions.
- Trial name
- NCT03704051
- Testing
- Mode of Feeding (breastfeeding versus bottle-feeding)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- California Polytechnic State University-San Luis Obispo
Diabetes, Gestational
Gestational Diabetes Mellitus Trial (GDM)
Gestational diabetes mellitus (GDM) is a type of diabetes (high blood sugar) that occurs in pregnant women. This study will determine whether treating pregnant women who have mild GDM improves the health of their babies.
- Trial name
- GDM (NCT00069576)
- Testing
- nutritional counseling, self blood glucose monitoring
- Where
- 16 sites in United States
- Volunteers
- 7,381 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Postpartum Depression, Small for Gestational Age at Delivery
Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention
In the proposed study the investigators will develop an early prenatal preventive intervention targeting anxiety and conduct a randomized controlled trial in Pakistan to test its efficacy in reducing generalized anxiety disorder…
- Conditions
- Postpartum Depression, Small for Gestational Age at Delivery, Preterm Birth, Anxiety
- Trial name
- HMHB (NCT03880032)
- Testing
- Cognitive Behavioral Therapy Intervention for Anxiety
- Where
- Pakistan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Pregnancy
Optimizing Dose of Bupivacaine in Combined Spinal Epidurals To Reduce Side Effects
The purpose of this study is to determine what dose of medication administered through a combined spinal epidural (CSE) provides the optimal pain relief with the minimal amount of side effects.
- Trial name
- NCT02159807
- Testing
- Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Pregnancy, Child Development
Improving Maternal and Child Health Through Prenatal Fatty Acid Supplementation
The purpose of the study is to test whether nutritional supplementation during pregnancy is associated with 1) improved maternal health during pregnancy; 2) improved infant birth and neurodevelopmental outcomes, and 3) whether…
- Trial name
- NAPS (NCT02647723)
- Testing
- DHA, Sugar pill
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Fetal Monitoring, Patient Comfort
Evaluation of the Effects of Different Positions Given During Antenatal Electro-Fetal Monitoring
The objective of this study was to assess the effects of different maternal positions during electronic fetal monitoring (EFM) on maternal and fetal health outcomes.
- Conditions
- Fetal Monitoring, Patient Comfort, Maternal Health
- Trial name
- NCT05863156
- Testing
- Right side lying position, Semi Fowler, left side lying position
- Where
- Turkey (Türkiye)
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Hypertension
A Pharmacist Intervention to Improve Mother and Child Health
The goal of this clinical trial is to learn if a research pharmacist can improve the health of new mothers and their babies. The main questions it aims to answer are: Will postpartum women who had elevated blood pressure during…
- Trial name
- NCT06073054
- Testing
- Research Pharmacist
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Iowa
Postpartum Depression, Parenting
Social Media Intervention for Postpartum Depression
This study is intended to compare the acceptability and feasibility and explore outcomes related to two different formats of a parenting program for mothers with postpartum depressive symptoms.
- Trial name
- NCT02355067
- Testing
- Social Media Intervention, Traditional In-Person Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Depression
Maternal Depression Treatment in HIV
Cluster randomized controlled trial to compare the effects of task-shifted, evidence-based depression care vs. usual care on adherence to each step of the prevention of mother-to-child-transmission (PMTCT) care cascade at 8…
- Trial name
- M-DEPTH (NCT03892915)
- Testing
- evidence-based depression treatment
- Where
- Uganda
- Volunteers
- 391 people
- Sponsor
- RAND
Postpartum Depression
Behavioral Change in the Mother-Infant Dyad: Preventing Postpartum Depression
Postpartum depression (PPD) is undertreated and the consequences of this are substantial for women and children. Studies show that infant cry/fuss and sleep behavior are associated with PPD, and that parenting interventions can…
- Trial name
- NCT01379781
- Testing
- Behavioral Intervention for PPD
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
HIV Infections
Safety and Pharmacokinetics (PK) of Raltegravir in HIV (Human Immunodeficiency Virus)-Infected Children and Adolescents
Integrase is 1 of 3 HIV (Human Immunodeficiency Virus)-1 enzymes required for viral replication. Raltegravir is a drug that prevents integrase from working properly.
- Trial name
- NCT00485264
- Testing
- Raltegravir poloxamer film coated tablet, Raltegravir chewable tablet, Raltegravir oral granules for suspension (20 mg/mL)
- Where
- 42 sites in United States, Argentina and 4 more
- Volunteers
- 153 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Overweight, Obesity
Toddler Overweight Prevention Study Among Low-Income Families
The hypothesis is that toddlers with parents who are randomized to a parenting intervention and toddlers with parents who are randomized to the maternal intervention focused on maternal diet and physical activity will be more…
- Conditions
- Overweight, Obesity, Depression
- Trial name
- TOPS (NCT02615158)
- Testing
- Maternal Physical Activity and Nutrition, Parenting, Child Safety
- Where
- 2 sites in United States
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Meningomyelocele, Spinal Dysraphism
Management of Myelomeningocele Study (MOMS)
Spina bifida (myelomeningocele) is a complex birth defect in which a portion of the spinal cord is not fully developed. The overlying bones and skin are incompletely formed and the underdeveloped area of the spinal cord is…
- Trial name
- MOMS (NCT00060606)
- Testing
- Prenatal Myelomeningocele Repair Surgery, Postnatal Myelomeningocele Repair Surgery
- Where
- 3 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Sexually Transmitted Infection, Hiv
A Comprehensive HIV Prevention Package for South African Adolescent Girls and Young Women: IMARA SA
Programs which go beyond individual-level behavior change to reduce HIV and STI infections among adolescent girls and young women in sub-Saharan Africa are essential to meet global HIV targets.
- Trial name
- IMARA-SA pilot (NCT05504954)
- Testing
- IMARA-SA (intervention group), Health promotion control group
- Where
- South Africa
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Malignant Neoplasm
Haploidentical Donor Hematopoietic Stem Cell Transplant in Treating Patients With Hematologic Malignancies
This phase II trial studies how well haploidentical donor hematopoietic stem cell transplant works in treating patients with hematologic malignancies.
- Trial name
- NCT01871441
- Testing
- Total-body irradiation, Donor lymphocytes infusion (DLI), Cyclophosphamide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development
Maternal Adversity, Vulnerability and Neurodevelopment
Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project is a prospective community-based, pregnancy and birth cohort of Canadian mother-child dyads.
- Conditions
- Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development, Infant Behavior
- Trial name
- MAVAN (NCT03434457)
- Where
- Canada
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
HIV Infections, Herpes Simplex
HSV-2 Suppression to Reduce Maternal HIV-1 RNA Levels During Pregnancy and Breastfeeding
In this study, we will determine whether treating pregnant and breastfeeding women co-infected with human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 2 (HSV-2) with daily valacyclovir will reduce HIV-1…
- Trial name
- VIP (NCT00530777)
- Testing
- valacyclovir
- Where
- Kenya
- Volunteers
- 148 people
- Sponsor
- University of Washington
Mental Health Issue, Hiv
Healthy Mothers: an Intervention to Support Perinatal Women Living With HIV in Kenya
The investigators will recruit 40 pregnant women living with HIV divided into 2 groups (n=20 intervention group, n=20 control group).
- Conditions
- Mental Health Issue, Hiv, Breastfeeding, Exclusive
- Trial name
- NCT05219552
- Testing
- personalized lactation support
- Where
- 2 sites in Kenya
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Pregnancy, Labor Pain
Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes
Fetal heart rate patterns are an important parameter in the diagnosis of non-reassuring fetal status. Combined-spinal epidural analgesia is a method of initiating labor analgesia used by approximately 90% of the parturients at…
- Trial name
- NCT02121184
- Testing
- Routine oxytocin, Half-dose oxytocin
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Anxiety Disorders
Effects of Maternal Interpretation Biases on Child Anxiety and Related Responses
The purpose of this study is to expand our understanding of the intergenerational transmission of cognitive risk for childhood anxiety disorders by examining whether changes in maternal interpretations of situations result in…
- Trial name
- NCT02095340
- Testing
- Positive Interpretation Bias Training, Neutral Interpretation Bias Training
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Houston