Clinical trials: Mother-to-Child Transmission
Mother-to-child HIV Transmission
The Kabeho Study: Kigali Antiretroviral and Breastfeeding Assessment for the Elimination of HIV
The study design includes an observational prospective cohort of HIV-positive pregnant/postpartum women and their infants enrolled during antenatal clinics (or immediately postpartum) from prevention of mother-to-child…
- Trial name
- Kabeho (NCT02295800)
- Testing
- Standard of care, Semi-structured interviews
- Where
- Rwanda
- Volunteers
- 1,216 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV Infections
Nevirapine Resistance Study: Nevirapine Resistance Among HIV-Infected Mothers
The purpose of this study is to determine whether the addition of zidovudine (ZDV) and lamivudine (3TC) at the onset of labor and for up to seven days postpartum to single-dose nevirapine (NVP) is associated with a lower…
- Trial name
- NCT00164762
- Where
- Malawi
- Volunteers
- 126 people
- Sponsor
- Centers for Disease Control and Prevention
Human Immunodeficiency Virus
A Multidisciplinary "Integrated Management Team to Improve Maternal-Child Outcomes (IMPROVE)" Intervention to Improve Maternal and Child Outcomes in Lesotho
This study aims to improve maternal and child health (MCH) outcomes by implementing and evaluating a multidisciplinary "Integrated Management Team to Improve Maternal-Child Outcomes (IMPROVE)" intervention to increase MCH…
- Trial name
- IMPROVE (NCT04598958)
- Testing
- IMPROVE
- Volunteers
- 1,004 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV, HIV Infections
Mobile Phone Technology for Prevention of Mother-to-Child Transmission of HIV: Acceptability, Effectiveness, and Cost (Kenya)
Although gains have been made in achieving the health-related Millennium Development Goals (MDG), much is still needed in countries affected by high levels of HIV/AIDS.
- Conditions
- HIV, HIV Infections, AIDS, Antiretroviral Therapy
- Trial name
- NCT01645865
- Testing
- Control, Intervention
- Where
- Kenya
- Volunteers
- 600 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
HIV-1
Prevention of Mother-to-child Transmission of HIV-1 Using a Responsive Intervention
The second visit of the Expanded Programme of Immunization when the child is 2 months old (EPI-2) represents a unique opportunity to link the EPI and PMTCT programmes and to introduce preventive and therapeutic rescue…
- Trial name
- PROMISE-EPI (NCT03870438)
- Testing
- Lamivudine Oral Solution
- Where
- 6 sites in Burkina Faso, Zambia
- Volunteers
- 1,506 people
- Sponsor
- ANRS, Emerging Infectious Diseases
HIV Infection
Effects of Facility-based Mother Support Groups on Prevention of mother-to Child Transmission Outcomes in Zimbabwe
The investigators hypothesize that a strategy of establishing facility-based mother support groups (MSGs) for HIV-positive mothers will result in increased retention rates of HIV-exposed infants in clinic-based PMTCT follow-up…
- Trial name
- EPAZ (NCT02216734)
- Testing
- Mother support groups for HIV+ mothers
- Where
- 2 sites in Zimbabwe
- Volunteers
- 300 people
- Sponsor
- Family AIDS Caring Trust
HIV Infections
NNRTI vs PI Regimens for HIV Infected Women After They Have Taken Nevirapine to Prevent Mother-To-Child HIV Transmission
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are commonly included in anti-HIV drug regimens. However, HIV infected women who have previously taken the single dose NNRTI nevirapine (SD NVP) for the prevention of…
- Trial name
- OCTANE (NCT00089505)
- Testing
- Emtricitabine, Emtricitabine/Tenofovir disoproxil fumarate, Lopinavir/Ritonavir
- Where
- 11 sites in Botswana, Kenya and 5 more
- Volunteers
- 745 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Maternal and Child Health
Evaluation of the Effectiveness of a Quality Improvement Intervention
This rigorous evaluation demonstrated that implementation of a time-limited quality improvement strategy effectively improved coverage of some components of an integrated maternal and child health service in a complex health…
- Trial name
- NCT04278612
- Testing
- Quality improvement intervention to strengthen health service provision
- Volunteers
- 1,438 people
- Sponsor
- University of KwaZulu
HIV-infection, Pregnancy
The Effect of Phenytoin on the Pharmacokinetics of Nevirapine and the Development of Nevirapine Resistance
The primary objective of this two-phase trial is as follows: To determine the elimination half-life of NVP in HIV positive pregnant women receiving it as a single dose in labour in addition to the ZDV and 3TC with or without…
- Conditions
- HIV-infection, Pregnancy, Mother to Child Transmission
- Trial name
- VITA 2 (NCT01187719)
- Testing
- phenytoin
- Where
- 2 sites in Tanzania, Zambia
- Volunteers
- 66 people
- Sponsor
- Radboud University Medical Center
HIV Infections
Evaluation of the Population-level Impact of PMTCT Option B+ in Zimbabwe
This study evaluates the impact of Zimbabwe's program for the prevention of mother-to-child HIV transmission (PMTCT) on vertical transmission of HIV infection and HIV-free survival among infants exposed to HIV.
- Trial name
- NCT03388398
- Volunteers
- 30,642 people
- Sponsor
- University of California, Berkeley
Mortality
Lufwanyama Neonatal Survival Project
We seek to determine whether we can reduce day 28 mortality in Zambian newborns by training traditional birth attendants a modified version of the neonatal resuscitation protocol (NRP) and by improving their abiltiy to identify…
- Trial name
- LUNESP (NCT00518856)
- Testing
- Neonatal resuscitation protocol, Standard of care
- Volunteers
- 3,559 people, healthy volunteers welcome
- Sponsor
- Boston University
Partner Abuse, Depression
Addressing Intimate Partner Violence, Mental Health, and HIV in Antenatal Care
This quasi-experimental feasibility study recruit n=40 participants from each of two public antenatal clinics in Johannesburg, South Africa. Using the Bowen et al.
- Conditions
- Partner Abuse, Depression, Adherence, Medication
- Trial name
- NCT05389358
- Testing
- Asiphephe health worker training, Asiphephe therapeutic sessions, IPV assessment
- Where
- 2 sites in South Africa
- Volunteers
- 80 people
- Sponsor
- University of Witwatersrand, South Africa
Human Immunodeficiency Virus, Mental Disorder
Integrated Mental Health Care for Pregnant Women With HIV in Kenya: The Tunawiri Study
This study seeks to improve mental health, pregnancy, and HIV outcomes among pregnant and postpartum women living with HIV with common mental health disorders in Kenya.
- Trial name
- NCT06117163
- Testing
- Collaborative Care Model
- Where
- Kenya
- Volunteers
- 900 people
- Sponsor
- University of Colorado, Denver
Hepatitis B, Pregnancy
Antiviral Prophylaxis and Infant Vaccination to Prevent Perinatal Hepatitis B Infection
Most new hepatitis B virus (HBV) infections are acquired perinatally. In this study, pregnant women with HBsAg and HBeAg will receive tenofovir disoproxil fumarate during the last trimester of pregnancy and for two months…
- Trial name
- NCT03343431
- Testing
- Anti-HBV antiviral prophylaxis
- Where
- 20 sites in Laos, Thailand
- Volunteers
- 504 people
- Sponsor
- Institut de Recherche pour le Developpement
Early Childhood Development (ECD)
Evaluation of an Early Childhood Development Intervention Among Children Born to HIV-Infected Women in Eswatini
With increased use of effective strategies to prevent HIV transmission from women to their infants, the number of HIV infected children has dramatically decreased.
- Trial name
- NCT04114305
- Testing
- ECD Intervention
- Volunteers
- 431 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
HIV Infection, Pregnancy
An Intervention to Improve Antenatal Access to CD4 Testing and HAART in Botswana
Access to highly active antiretroviral therapy can improve maternal health outcomes for the 4000 HIV- infected women who give birth daily and nearly eliminate transmission of HIV to their infants.
- Trial name
- NCT01836003
- Testing
- Tokafatso programmatic intervention
- Where
- Botswana
- Volunteers
- 422 people
- Sponsor
- Harvard School of Public Health (HSPH)
Syphilis, HIV Infections
Spotting Syphilis: A Dual Point-of-Care Syphilis Screening Initiative in a Low-Resource Healthcare Setting
The purpose of this study is to determine if a strategy utilizing the Chembio HIV/syphilis rapid point-of-care (POC) test for diagnosis of HIV and syphilis in pregnant women attending prenatal clinics in Guatemala will increase…
- Trial name
- NCT07498153
- Testing
- Chembio HIV/Syphilis rapid POC test
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- The University of Texas Health Science Center, Houston
HIV Infections
Feasibility and Pilot Efficacy of Flash-heated Breast Milk to Reduce Maternal-to-Child-Transmission of HIV in Tanzania
This study will investigate the feasibility of HIV positive mothers in Tanzania to correctly use the Flash-heat method to pasteurize their breast milk and for how long they are able to do so.
- Trial name
- Flash-heat (NCT00523510)
- Testing
- Infant feeding counseling that includes Flash-heat
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
HIV Infections
Reducing the Incidence of Nevirapine Resistance Mutations in Pregnant HIV Infected Women Who Receive Anti-HIV Drugs Prior to and After Giving Birth
The purpose of this study is to determine which of 3 different anti-HIV drug regimens given to HIV infected pregnant women during and after their pregnancies is most effective in reducing the incidence of nevirapine (NVP)…
- Trial name
- NCT00109590
- Testing
- Didanosine, enteric-coated, Lopinavir/ritonavir, Nevirapine
- Where
- 7 sites in Thailand
- Volunteers
- 175 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatitis B Chronic Infection, Pregnancy
Tenofovir As Prevention Of Hepatitis b Mother-to-child Transmission
The World Health Organization recommends that all high endemic countries for HBV infection based their mother to child transmission prevention strategies on vaccination of all children and administration of immunoglobulins (HBIG)…
- Trial name
- TA-PROHM (NCT02937779)
- Testing
- Tenofovir disoproxil fumarate, Rapid tests HBe Ag
- Where
- 3 sites in Cambodia
- Volunteers
- 933 people
- Sponsor
- ANRS, Emerging Infectious Diseases