Clinical trials: Motion Sickness
Motion Sickness
A Comparative Bioavailability and Adhesion Performance Study, Comparing a New Scopolamine Transdermal Delivery System Formulation to the Currently Established Reference Transdermal Delivery System in Healthy Adult Participants.
In this comparative bioavailability and in vivo skin adhesion study, the impact of minor changes in qualitative composition of polyiso-Butylenes (PIB) from a different supplier and change of the manufacturing line of the micro…
- Trial name
- NCT02839135
- Testing
- Reformulated scopolamine patch, Marketed scopolamine patch
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Motion Sickness, Space, Motion Simulation
Combination of Intranasal Scopolamine and Sensory Augmentation to Mitigate G-transition Induced Motion Sickness and Enhance Sensorimotor Performance
The primary specific aim of this Field Test aim is to evaluate the feasibility and efficacy of administering the intranasal scopolamine gel in operational field settings using both astronaut and ground-control subjects that are…
- Conditions
- Motion Sickness, Space, Motion Simulation, Parabolic Flight
- Trial name
- NCT05852730
- Testing
- DPI-386 Nasal Gel, Other (e.g., promethazine, meclizine)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Repurposed Therapeutics, Inc.
Motion Sickness
Preliminary Evaluation of an Osteopathic Manipulative Treatment (OMT) to Prevent Motion Sickness Symptoms
Motion sickness directly impacts the readiness of the Army's aviation units. Severe motion sickness results in the dismissal of pilot and air crew candidates during initial training, while minor to moderate symptoms can be…
- Trial name
- NCT05611814
- Testing
- Osteopathic Manipulative Treatment
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Aeromedical Research Laboratory
Motion Sickness
Virtual Reality Sickness Questionnaire: Psychometrics in Stroke Patients
The aim of this study is to examine the effects of virtual reality on physiological factors (heart rate, blood pressure) in stroke patients and the psychometric properties of the Virtual Reality Sickness Questionnaire in…
- Trial name
- NCT07297862
- Testing
- Roller Coaster application
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Motion Sickness
Pharmacokinetic and Efficacy Profile Intranasal Scopolamine Spray
Part 1, the pharmacokinetic (PK) phase, will expand upon the pilot study conducted at Naval Medical Research Laboratory (NAMRL) and has the goal of determining bioavailability and time to Cmax in a larger representative sample.
- Trial name
- NCT02155309
- Testing
- Scopolamine
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Repurposed Therapeutics, Inc.
Motion Sickness, Vertigo
Sensory Training for Orientation and Balance
This is a preliminary study of how human beings control balance and how symptoms of visually-induced dizziness may result in falls.
- Conditions
- Motion Sickness, Vertigo, Dizziness, Fall
- Trial name
- NCT04331561
- Testing
- sensory re-weighting
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Visually Induced Motion Sickness in Healthy Volunteers
Effect of Transcutaneous Vagal Nerve Stimulation on Reducing Visually Induced Motion Sickness in Healthy Volunteers
Nausea is a common and distressing experience that often precedes vomiting. Amongst symptoms emanating from the gastrointestinal (GI) tract nausea can be considered somewhat unique, as on one hand it represents a normal, highly…
- Trial name
- NCT02177890
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wingate Institute of Neurogastroenterology
Elderly People, Living Alone in a Residence With Care Giver
Comparative Study of QuietCare
The objective of the study is to examine the efficacy and safety of QuietCare in a randomized, open study in elderly subjects living in assisted/ independent living facilities for 6 months.
- Trial name
- NCT01839825
- Testing
- QuietCare
- Where
- Japan
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- National Center for Geriatrics and Gerontology, Japan
Seasickness, Meclizine
Meclizine Plasma Levels in Responders and Non-responders
Motion sickness is a debilitating condition that can effect many crew members. Meclizine has long been known as an effective anti motion sickness drug.
- Trial name
- NCT04482985
- Testing
- Meclizine Hydrochloride
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Motion Sickness
Effects of Transdermal Scopolamine on Occupational Performance
The purpose of this study is to determine the effects of Transdermal scopolamine vs. placebo on ship navigation performance under simulated heavy sea conditions.
- Trial name
- NCT00374478
- Testing
- Scopolamine
- Where
- Sweden
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Boston University
Motion Sickness, Seasickness
Galvanic Vestibular Stimulation as a Novel Treatment for Seasickness
subjects with severe seasickness, who failed to habituate to sea conditions after at least six month of active sailing, were enrolled to the single-blind randomized control study.
- Conditions
- Motion Sickness, Seasickness, Habituation, Vestibular Time Constant
- Trial name
- NCT05004818
- Testing
- GVS stimulation coupled with inverse phase rotatory chair stimulation at sinusoidal harmonic acceleration protocol
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Drug Mechanism, Metabolism Medication Toxicity
Pharmacology Space Kit (PSK) - Dried Blood Spot for Caffeine Pharmacokinetics Under Microgravity Conditions
The PSK study is preliminary to the study of drug metabolism in space flight conditions. The investigators propose to use simplified blood sampling methods that can be applied in microgravity.
- Conditions
- Drug Mechanism, Metabolism Medication Toxicity, Space Motion Sickness
- Trial name
- PSK (NCT06431984)
- Testing
- prick test
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Motion Sickness
Three-Axis Wearable Adaptive Vestibular Stimulator
The purpose of this study is to improve current galvanic vestibular stimulation (GVS) technology to ease the motion sickness often associated with virtual reality (VR) simulation.
- Trial name
- NCT06106256
- Testing
- Galvanic Vestibular Stimulation (GVS), Flight simulations in virtual reality (VR), 3-DOF Bertec Portable Essential's dual-balance force plate system
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Motion Sickness
Nasal Gel for the Prevention and Treatment of Nausea Associated With Motion Sickness
Phase 3 clinical trial is a randomized, double-blind, placebo-controlled study to identify the safety, efficacy and pharmacokinetics of a repeated-dose regimen of DPI 386 nasal gel (intranasal scopolamine gel) for the prevention…
- Trial name
- NCT04184115
- Testing
- DPI-386 Nasal Gel
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Repurposed Therapeutics, Inc.
Motion Sickness, Postoperative Nausea and Vomiting
Gynecologic Endoscopic Surgery of Female Motion Sickness Patients
The goal of this clinical trial is to compare the analgesic effect of sufentanil and ibuprofen and the incidence of vomiting, and to choose better postoperative analgesic drugs for motion sickness patients.in describe participant…
- Conditions
- Motion Sickness, Postoperative Nausea and Vomiting, Ibuprofen
- Trial name
- NCT06232785
- Testing
- Ibuprofen, sufentanil
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Jilin University
Migraine, Vestibular Migraine
Analysis of Vestibular Compensation Following Clinical Intervention for Vestibular Schwannoma
Multiple sensory cues are typically generated by discrete events, and while they do not reach the cerebrum simultaneously, the brain can bind them temporally if they are interpreted as corresponding to a single event.
- Conditions
- Migraine, Vestibular Migraine, Vestibular Schwannoma, Motion Sickness
- Trial name
- NCT04196933
- Testing
- Temporal Binding Adaptation - PSS training, Temporal Binding Adaptation - PSS adaptation with VI stimulation, Chronic Motion-modulated Stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Prevention of Nausea Associated With Motion Sickness, Treatment of Nausea Associated With Motion Sickness
Study of the Safety and Efficacy of DPI-386 Nasal Gel on Ocean-Going Vessels
This multi-site Phase 3 clinical trial is a randomized, double-blind, placebo-controlled study to identify the safety and efficacy of DPI 386 nasal gel (intranasal scopolamine gel) for the prevention and treatment of nausea…
- Trial name
- INSCOP (NCT03920644)
- Testing
- Scopolamine Transdermal Patch [Transderm Scop], Scopolamine
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Naval Aeromedical Research Unit, Dayton
Stress, Psychological, Motion Sickness
Research on Quantification of VR(Virtual Reality) Related Stress and Relaxation
Current virtual reality device makes motion sickness and visual fatigue having limitation for recreation and other clinical approaches.
- Conditions
- Stress, Psychological, Motion Sickness, Visual Fatigue
- Trial name
- NCT02986555
- Testing
- Existing Biofeedback, Biofeedback accompanied with virtual reality
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Vestibular
Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels
The investigators will study adaptation of motion perception and manual control in altered gravity, including the effects of a drug (promethazine).
- Trial name
- NCT02136420
- Testing
- Promethazine, Hyper gravity training, No hypergravity training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Faisal_Karmali@MEEI.HARVARD.EDU
Motion Sickness
Prevention and Treatment of Nausea Associated With Motion Sickness in Senior Subjects
A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of the Safety, Efficacy and Pharmacokinetics of DPI 386 Nasal Gel for the Prevention and Treatment of Nausea Associated with Motion Sickness in Senior Subjects With…
- Trial name
- NCT03988530
- Testing
- Scopolamine
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Repurposed Therapeutics, Inc.