Clinical trials: Motor Disabilities
Hereditary Spastic Paraplegia, Adrenomyeloneuropathy
Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and Adrenomyeloneuropathy
Hereditary spastic paraplegia (HSP) is the group of inherited disorders, characterized by progressive gait disturbance. There is no established therapy. Adrenoleukodystrophy (AMN) is an x-linked hereditary disease.
- Trial name
- NCT03627416
- Testing
- rTMS
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- Jakub Antczak
X-linked Adrenoleukodystrophy
Exercise Study of Function and Pathology for Women With X-linked Adrenoleukodystrophy
The purpose is to see how X-linked adrenoleukodystrophy (X-ALD) is associated with strength and sensation using MRI, in women with X-ALD.
- Trial name
- NCT01594853
- Testing
- exercise training
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Impaired Glucose Tolerance, Obesity
Enhancing Fitness in Older Pre-diabetic Veterans
This study targets older adults (ages 60 and over) who are overweight (body mass index 25-40) with impaired fasting glucose (100 - 125).
- Conditions
- Impaired Glucose Tolerance, Obesity, Diabetes
- Trial name
- NCT00594399
- Testing
- Physical Activity Counseling
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- US Department of Veterans Affairs
Shoulder Impingement Syndrome
Exercise Application in the Treatment of Patients With Subacromial Pain Syndrome
This study evaluate the effectiveness of adding neuromuscular exercises with tactile, visual and auditory feedback to a scapula-focused treatment, both emphasizing the periscapular muscles on improvement of disability in patients…
- Trial name
- NCT02695524
- Testing
- Scapula-focused exercises, Motor control exercises
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Down Syndrome, Alzheimer Disease
The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome
The objectives of this study are to determine the feasibility and potential efficacy of remotely delivered group exercise sessions to increase daily moderate to vigorous physical activity in adults with Down syndrome, relative to…
- Trial name
- NCT04048759
- Testing
- Remote Low, Remote High, Personal Coach
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Kansas Medical Center
Down Syndrome
Blood Flow Regulation in Individuals With Down Syndrome - Training Study
Work capacity is an important predictor of declining health or physical function, and of mortality, and is commonly measured as peak oxygen consumption.
- Trial name
- NCT04854122
- Testing
- Combined exercise intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Mobility Limitation
Lower Extremity Muscle and Function in the Elderly: Study 2
This research study is looking to compare the effects of two uniquely different power training interventions (high force, lower velocity versus low force, high velocity) on changes in mobility status among older individuals at…
- Trial name
- NCT01614392
- Testing
- High velocity low force Power Training, Low velocity high force Power Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tufts University
Obesity
School-based Physical Activity Intervention for Obesity Among Adolescents With Intellectual Disability in Hong Kong
Considering that children with intellectual disability (ID) might be more vulnerable to obesity than their counterparts in the general population.
- Trial name
- NCT04463069
- Testing
- Adapted physical activity
- Where
- China
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Cerebrovascular Disease; Sequelae
Machines Assisting Recovery From Stroke
Locomotor disability remains a major obstacle to community function in stroke survivors. This disability is best characterized by the reduced gait speed and enhanced risk of falls that is observed in the majority of stroke…
- Trial name
- MARS (NCT02787694)
- Testing
- Factor Targeted Walking Training, treadmill
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham
Sedentary Lifestyle, Risk of Disability
The LIFE Study - Lifestyle Interventions and Independence for Elders
Based upon promising results from a pilot study among 424 sedentary older adults who were randomized to a physical activity intervention or a successful aging health education intervention, a Phase 3 multi-center randomized…
- Conditions
- Sedentary Lifestyle, Risk of Disability, Aging
- Trial name
- LIFE (NCT01072500)
- Testing
- Physical Activity, Successful Aging
- Where
- 8 sites in United States
- Volunteers
- 1,635 people
- Sponsor
- University of Florida
Mobility Limitation
Effect of Whey Protein Supplementation and Resistance Exercise on Muscle Parameters in Older Adults
This research study is looking at the effects of a whey protein nutritional supplement on changes in muscle mass, strength and physical function in response to a 6 month program of strength training exercise.
- Trial name
- NCT00635739
- Testing
- Whey protein
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tufts University
Physical Disability
Weight Loss Physical Disabilities
The objective of this study is to compare weight loss (6 mos.) and maintenance (18 mos.) between an individual home visit intervention (IH) and an intervention delivered remotely via video conferencing to groups of…
- Trial name
- NCT04046471
- Testing
- enhanced Stop Light Diet, Group Remote, Individual In-Person
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of Kansas Medical Center
Stroke, Cerebrovascular Accident
Combining Armodafinil With Neuro-rehabilitation to Improve Neurological Recovery and Reduce Disability Post-Stroke
Armodafinil is an FDA approved medication with wakefulness-promoting properties. It is a relatively safe agent with interesting neurochemical effects on the catecholamine system, producing an improvement in cognitive function…
- Conditions
- Stroke, Cerebrovascular Accident, Hemiparesis
- Trial name
- NCT01896128
- Testing
- Armodafinil
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Burke Rehabilitation Hospital
Cerebral Palsy, Child, Preschool
Effect of Power Wheelchairs on the Development and Function of Young Children With Severe Physical Disabilities
Self-produced locomotion often is limited in children with cerebral palsy and other conditions that cause severe motor impairments.
- Trial name
- NCT01115998
- Testing
- Power wheelchair, No power wheelchairs
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Oklahoma
Autism Spectrum Disorder, Developmental Disability
Propranolol for Challenging Behaviors in Autism
Severe challenging behaviors such as aggression and self-injury can cause significant morbidity and decrease the quality of life for individuals with Autism Spectrum Disorders (ASD).
- Conditions
- Autism Spectrum Disorder, Developmental Disability, Aggression, Self-Injurious Behavior
- Trial name
- NCT04047355
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Post-polio Syndrome, Physical Activity
Glutathione and Health With Post-Polio Syndrome
In this study, people who have symptoms of post polio will take oral glutathione supplements for three months. Their levels of fatigue, physical activity and sleep efficiency will be assessed.
- Conditions
- Post-polio Syndrome, Physical Activity, Depression, Pain
- Trial name
- NCT01402570
- Testing
- Glutathione
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Low Back Pain
The Back Exercises to Neutralize Disability Study
A pilot randomized control trial (RCT) to generate effect sizes on the effects of blood flow restricted exercise on trunk extensor cross-sectional area (primary outcome), strength and endurance, whole body and regional lean mass…
- Trial name
- BEND (NCT02308189)
- Testing
- Exercise with blood flow restriction, Exercise
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ohio University
Adolescent Behavior, Intellectual Disability
Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities
The objective of this study is to compare the effect of two strategies to increase MVPA in adolescents with intellectual and developmental disabilities (IDD): a single level intervention delivered to the adolescent only, and a…
- Conditions
- Adolescent Behavior, Intellectual Disability, Down Syndrome, Physical Activity
- Trial name
- NCT03684512
- Testing
- Group Exercise Sessions, Individual Support Sessions, Facebook Group
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- University of Kansas
Stroke, Physical Activity
Activating Behavior for Lasting Engagement After Stroke
Stroke survivors demonstrate high levels of sedentary behavior, placing them at risk for exacerbation of chronic health conditions. This may lead to recurrent stroke.
- Conditions
- Stroke, Physical Activity, Sedentary Lifestyle, Behavior, Health
- Trial name
- ABLE (NCT03305731)
- Testing
- Activating Behavior for Lasting Engagement
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Pittsburgh