Clinical trials: Motor Disability
Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
Motor Asymmetry in Progressive Multiple Sclerosis Patients
Project Rational A better understanding of the causes of physical disability is an important unmet need in progressive Multiple Sclerosis patients.
- Trial name
- MAP-MS (NCT04918225)
- Testing
- Magnetic Resonance Imaging, Neurological examination, Multiple Sclerosis Functional Composite
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
AMN, AMN Gene Mutation
Study of Disease Progression in Adults With Inherited Forms of Spastic Paraplegia
The course of AMN-related disabilities over time is poorly or incompletely understood due to a limited number of patients and lack of treatments.
- Conditions
- AMN, AMN Gene Mutation, X-ALD
- Trial name
- CYGNET (NCT05008874)
- Testing
- Natural History Observation
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 65 people
- Sponsor
- SwanBio Therapeutics, Inc.
Lumbar Disc Herniation
Telerehabilitation After Lumbar Disc Herniation Surgery
This randomized controlled trial evaluated the effectiveness of a telerehabilitation-based exercise program in individuals who had undergone surgery for lumbar disc herniation.
- Trial name
- NCT07889817
- Testing
- Home Exercise Program, Telerehabilitation-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Hasan Kalyoncu University
Down Syndrome
Comparative Effects of Dual Task Training and Embodied Learning on Dual Task Performance in Children With Down Syndrome
This study aims to compare the effectiveness of embodied learning and dual-task training in improving coordination and cognitive function in children with Down syndrome.
- Trial name
- NCT06943144
- Testing
- Dual task Training, Embodied Learning
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Physical Disability
Weight Loss Physical Disabilities
The objective of this study is to compare weight loss (6 mos.) and maintenance (18 mos.) between an individual home visit intervention (IH) and an intervention delivered remotely via video conferencing to groups of…
- Trial name
- NCT04046471
- Testing
- enhanced Stop Light Diet, Group Remote, Individual In-Person
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- University of Kansas Medical Center
Cerebrovascular Disorders
Treatment for Movement Problems in Elderly Stroke Patients
After a stroke, many patients are left with an impaired arm. Restricting the use of the good arm may improve the use of the bad arm.
- Trial name
- NCT00059696
- Testing
- Constraint-Induced Movement Therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Down Syndrome
Effects of (tDCS) Combined With Virtual Reality Versus CPT on Brain, Cognitive, and GMS in Children With DS.
This randomized controlled trial aims to compare the effects of transcranial direct current stimulation (tDCS) combined with virtual reality-based training versus conventional physical therapy on brain activity, cognitive…
- Trial name
- NCT07385066
- Testing
- Conventional Physical Therapy, Experimental group (tDCS + Virtual Reality)
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Superior University
Obesity
A Family-Based Weight Loss Intervention for Youth With Intellectual Disability
The purpose of this randomized controlled trial is twofold. First, to examine the efficacy of a 24-session, 6-month family-based behavioral intervention (FBBI) - as compared to a waitlist FBBI group, which later receives the same…
- Trial name
- HealthU (NCT02033642)
- Testing
- Family Based Behavioral Intervention, Maintenance
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Cerebral Palsy
Motor Disability of Children With Cerebral Palsy Using Motor Transcranial Magnetic Stimulation
Transcranial magnetic stimulation (TMS) has opened new potential avenues for the treatment of neuropsychiatric diseases via the effects of modulation on neuroplasticity.
- Trial name
- NCT02518867
- Testing
- high intensity iTBS, low intensity iTBS
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Rotator Cuff Related Shoulder Pain
Implementation of Shoulder School in Albania
Shoulder pain is a common musculoskeletal condition that can cause pain, movement limitations, disability, and difficulties performing daily and occupational activities.
- Trial name
- NCT07885878
- Testing
- Shoulder school, Standard Care (in control arm)
- Volunteers
- 50 people
- Sponsor
- University of Valladolid
Impaired Glucose Tolerance, Obesity
Enhancing Fitness in Older Pre-diabetic Veterans
This study targets older adults (ages 60 and over) who are overweight (body mass index 25-40) with impaired fasting glucose (100 - 125).
- Conditions
- Impaired Glucose Tolerance, Obesity, Diabetes
- Trial name
- NCT00594399
- Testing
- Physical Activity Counseling
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- US Department of Veterans Affairs
Chronic Renal Failure
Efficacy of an Intradialysis Combined Training Program on Disability Level and Physical Performance.
The patient subjected to hemodialysis has a low physical capacity due to being advanced in years and the complexity of the process, which is encouraged by family members and caregivers who lead them to a total dependence.
- Trial name
- PTH-CKD0113 (NCT02883309)
- Testing
- intradialytic physical training program
- Sponsor
- Universidad Austral de Chile
Physical Disability
Virtual Reality in Children With Hemiparesis
children with cerebral palsy have impaired selective motor control and upper limb functions that affect their performance
- Trial name
- NCT04679779
- Testing
- designed occupational therapy program, Wii virtual reality games
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Multiple Disabilities
Efficacy of Passive Oral Motor Therapy on Drooling in Children With Multiple Disabilities
This study was formulated to determine the efficacy of passive oral motor regimen for drooling in children with multiple disabilities. Seven subjects aged 7-19yrs were taken in the study.
- Trial name
- NCT02333981
- Testing
- passive oral motor therapy for drooling
- Volunteers
- 7 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Leukodystrophy, White Matter Disease
The Myelin Disorders Biorepository Project
The Myelin Disorders Biorepository Project (MDBP) seeks to collect and analyze clinical data and biological samples from leukodystrophy patients worldwide to support ongoing and future research projects.
- Conditions
- Leukodystrophy, White Matter Disease, Leukoencephalopathies, 4H Syndrome
- Trial name
- MDBP (NCT03047369)
- Where
- 23 sites in United States
- Volunteers
- 12,000 people
- Sponsor
- Children's Hospital of Philadelphia
Rare Diseases, Autism or Autistic Traits
Baker Gordon Syndrome Natural History Study
The goal of this study is to conduct a prospective, longitudinal assessment of the natural clinical progression of children and adults with Synaptotagmin1-Associated Neurodevelopmental Disorder also known as Baker Gordon Syndrome…
- Conditions
- Rare Diseases, Autism or Autistic Traits, Development Delay, SYT-SSX Fusion Protein Expression
- Trial name
- BAGOS (NCT06399952)
- Testing
- Brain Magnetic Resonance Imaging (MRI), Whole Genome Sequencing, Induced Pluripotential Stem Cells
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Missouri-Columbia
Severe Intellectual Disability
Gross Motor Skills Predict Adaptive Behavior in Institutionalized Children With Severe Intellectual Disability: A Cross-Sectional Study
This study examines whether gross motor skills are linked to everyday functioning (adaptive behavior) in children with severe intellectual disability (ID) living in social welfare institutions.
- Trial name
- TGMD-ADQ (NCT07358143)
- Testing
- Test of Gross Motor Development-Second Edition (TGMD-2) Assessment, Adaptive Behavior Questionnaire for Children (ADQ) Assessment
- Where
- China
- Volunteers
- 227 people
- Sponsor
- Xili Wen
Critical Illness, Sepsis
Measuring Outcomes of Activity in Intensive Care
Millions of older adults are hospitalized for a critical illness each year and although they are more likely than ever to survive this illness, they commonly face significant morbidity in the form of disabilities in basic…
- Conditions
- Critical Illness, Sepsis, Mechanical Ventilation, Physical Activity
- Trial name
- MOSAIC (NCT03115840)
- Where
- 2 sites in United States
- Volunteers
- 312 people
- Sponsor
- Vanderbilt University Medical Center
Down Syndrome
Infants With Down Syndrome on a Different Surface
This study included infants with Down syndrome who applied to the Faculty of Physical Therapy and Rehabilitation, Developmental and Early Physiotherapy Unit of Hacettepe University.
- Trial name
- NCT04539535
- Testing
- General Movements Assessment on two different surfaces in infants with DS and typically infants on the same day
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Neck Pain, Whiplash Injuries
Implementation and Evaluation of Neck-specific Exercises
Persistent pain and disability in whiplash-associated disorders (WAD) grade II and III are common. Randomized controlled studies (RCTs) have shown promising result for neck-specific exercise (NSE) programmes in chronic WAD with…
- Conditions
- Neck Pain, Whiplash Injuries, Neck Disorder
- Trial name
- NCT05198258
- Testing
- Implementation strategy - experimental group, Implementation - control group
- Where
- 7 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Sormland County Council, Sweden