Clinical trials: Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Noninvasive Ventilation in ALS Patients With Mild Respiratory Involvement
Non-invasive ventilation or BiPAP®, which is a form of breathing support delivered through a facemask, is a successful treatment for the respiratory complications of amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT00386464
- Testing
- noninvasive positive pressure ventilation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Amyotrophic Lateral Sclerosis (ALS)
Safety Study of XT-150 in Participants With ALS
This is a Phase 1, open-label, multi-center safety study of XT-150 in adult participants with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT06704347
- Testing
- XT-150
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Xalud Therapeutics, Inc.
Muscle Cramps in Amyotrophic Lateral Sclerosis
Mexiletine for the Treatment of Muscle Cramps in ALS
The purpose of this study is to determine if mexiletine is effective for the treatment of muscle cramps in Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NCT01811355
- Testing
- Mexiletine
- Where
- 6 sites in United States
- Volunteers
- 23 people
- Sponsor
- Bjorn Oskarsson, MD
Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia
Phenotype, Genotype and Biomarkers 2
The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic…
- Conditions
- Amyotrophic Lateral Sclerosis, Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, Progressive Muscular Atrophy
- Trial name
- PGB2 (NCT04875416)
- Where
- 4 sites in United States, South Africa
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Miami
Amyotrophic Lateral Sclerosis
HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose
The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS.
- Trial name
- NCT05136885
- Testing
- SLS-005
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- Merit E. Cudkowicz, MD
Amyotrophic Lateral Sclerosis
Safety and Preliminary Efficacy of Aleeto in Amyotrophic Lateral Sclerosis
This study is a single-center, randomized, double-blind, placebo parallel-controlled, dose-escalation clinical study. The aim of this study was to evaluate the safety, tolerability, and preliminary effect of Aleeto in adult…
- Trial name
- SPECIALS (NCT06181526)
- Testing
- Aleeto, intravenous injection, intrathecal injection
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Tiantan Hospital
Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Web Based Patient Care Database: ALSConnection.Org
The purpose is to collect data for ALS research. The data will be used to learn more about the origin of ALS and to improve quality of care for people with ALS.
- Trial name
- NCT00302198
- Testing
- ALS Registry
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- Forbes Norris MDA/ALS Research Center
ALS
A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients
The purpose of this study is to investigate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of TCD601 (siplizumab) in newly diagnosed adult ALS patients.
- Trial name
- AURORA (NCT06453668)
- Testing
- TCD601
- Where
- 3 sites in Sweden
- Volunteers
- 7 people
- Sponsor
- ITB-Med LLC
Amyotrophic Lateral Sclerosis, Alzheimer Disease
Study of the Role of G72 in Amyotrophic Lateral Sclerosis: Biomarker Discovery and Mechanism Investigation
G72 gene is located on the common linkage locus in bipolar disorder and schizophrenia, and it encodes D-amino acid oxidase activator (DAOA).
- Conditions
- Amyotrophic Lateral Sclerosis, Alzheimer Disease, Parkinson's Disease
- Trial name
- NCT01378026
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Neurodegenerative Disorders, Parkinson Disease
An Innovative Method in SAliva Samples for the Early Differential Diagnosis of High-impact NeuroDegenerative Diseases Through Raman Spectroscopy
The aim of the study is to validate a salivary test that allows for rapid and accurate objective diagnosis in the context of neurodegenerative diseases, a complex of diseases that includes Alzheimer's Dementia, Frontotemporal…
- Conditions
- Neurodegenerative Disorders, Parkinson Disease, Alzheimer Disease, Parkinsonian Disorders
- Trial name
- SANDY (NCT06875739)
- Where
- 4 sites in Italy
- Volunteers
- 310 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Amyotrophic Lateral Sclerosis
A Registered Cohort Study on Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a kind of motor neuron degeneration disorder without effective therapy. This registered cohort study will provide further insights into the clinical course of ALS, and investigate…
- Trial name
- NCT04008329
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Amyotrophic Lateral Sclerosis
Study of SPG302 in Healthy Volunteers and ALS Participants
The first-in-human Phase 1 study described herein will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SPG302 in healthy volunteers and ALS participants
- Trial name
- NCT05882695
- Testing
- SPG302
- Where
- 4 sites in Australia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Spinogenix
Spinal Cord Injury (SCI), Amyotrophic Lateral Sclerosis (ALS)
Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS
Most neurological injuries such as spinal cord injuries (SCI) and amyotrophic lateral sclerosis (ALS) spare a portion of nerve circuitry.
- Trial name
- NCT02469675
- Testing
- Transcranial magnetic stimulation, Median nerve stimulation, Cervical transcutaneous stimulation
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Bronx VA Medical Center
Amyotrophic Lateral Sclerosis, Neurodegenerative Disease
Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient Population
New technologies are giving people with motor disabilities alternative communication and control channels. The investigators are interested in using the Cyberlink Control System as a hands free means to access a computer for…
- Conditions
- Amyotrophic Lateral Sclerosis, Neurodegenerative Disease, Motor Neuron Disease
- Trial name
- NCT00718497
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Drexel University College of Medicine
Amyotrophic Lateral Sclerosis
Monitoring of Non-invasive Ventilation During Sleep in ALS
Non-invasive ventilation (NIV) has already shown to improve survival and quality of life in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT01889043
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Amyotrophic Lateral Sclerosis, Pseudobulbar Affect
Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect
The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and…
- Trial name
- NCT06396260
- Testing
- Diffusion Kurtosis Imaging (DKI), Resting State Magnetoencephalography
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Amyotrophic Lateral Sclerosis, Plasmapheresis
Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP
Patient with amyotrophic lateral sclerosis (ALS) having anti-NRIP autoantibody showed titer-dependent detrimental Effects. Plasmapheresis might benefit this subgroup of patients via removal of anti-NRIP autoantibody
- Trial name
- PALATIN (NCT05562960)
- Testing
- Plasmapheresis
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Amyotrophic Lateral Sclerosis, Gastrointestinal Intolerance
Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS
The main objective of the proposed study is to evaluate if oral intake of EN formula preceding Gtube placement will impact tolerance upon placement and feeding via Gtube in pALS.
- Conditions
- Amyotrophic Lateral Sclerosis, Gastrointestinal Intolerance, Enteral Nutrition Therapy
- Trial name
- NCT06609213
- Testing
- Medical Food
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Andrea Charvet
Pure Autonomic Failure, Amyotrophic Lateral Sclerosis
Anti-Cholinergic Receptors Antibodies, Autonomic Profile and Dysautonomia Symptoms in PAF, ALS and POTS (DISAUT-AB)
Anti alfa-3 and alfa-7 ganglionic cholinergic receptors (anti-AChRs) antibodies (Abs) plasma removal by plasmapheresis (1,2) acutely improved dysautonomia symptoms in case reports with Pure Autonomic Failure (PAF) (3).
- Conditions
- Pure Autonomic Failure, Amyotrophic Lateral Sclerosis, Postural Orthostatic Tachycardia Syndrome, Anti-Cholinergic Receptors Antibodies
- Trial name
- DISAUT-AB (NCT04875949)
- Testing
- Immunoabsorption/plasmapheresis procedure
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Istituto Clinico Humanitas
Amyotrophic Lateral Sclerosis
Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis
The purpose of this study is to evaluate the safety, tolerability, and feasibility of Blood-Brain Barrier (BBB) opening using transcranial MRI-guided focused ultrasound in conjunction with an intravenous ultrasound contrast agent…
- Trial name
- NCT03321487
- Testing
- Blood-Brain Barrier opening with MRgFUS
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- InSightec