Clinical trials: Motor Recovery
Cerebrovascular Accident
Effects and Mechanisms of Treatment Intensity of Mirror Therapy in Patients With Subacute Stroke
The purpose of this study will evaluate the long-term benefits, optimal dose and mechanisms of mirror therapy and its effects on physiological markers.
- Trial name
- NCT01655160
- Testing
- MT with low-intensity group (MT-LI), MT with moderate-intensity group, Mirror therapy with high intensity group
- Where
- Taiwan
- Volunteers
- 2 people
- Sponsor
- Chang Gung Memorial Hospital
Healthy Control, Spinal Cord Injury
Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury
This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control.
- Trial name
- NCT07814313
- Testing
- CST PAS, RST PAS
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Rehabilitation
tDCS Response Prediction Using EEG in Stroke
Patients with chronic stroke (>6 months after stroke) having unilateral upper limb hemiparesis will be recruited. Patients will maintain their usual inpatient rehabilitation including occupational therapy.
- Conditions
- Stroke, Rehabilitation, Transcranial Direct Current Stimulation, Motor Recovery
- Trial name
- NCT04830631
- Testing
- Cathodal transcranial direct current stimulation (tDCS) over the contralesional motor cortex
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Focused Ultrasound, Stroke
Neuromodulation Effect of Focused Ultrasound for Motor Recovery in Patients With Stroke
Transcranial focused ultrasound (tFUS) can be used as a non-invasive brain neuromodulation technique. Low-intensity focused ultrasound has been demonstrated to be safe and have neuromodulatory effects on the cerebral cortex in…
- Trial name
- NCT06391086
- Testing
- NaviFUS® Neuronavigation-guided focused ultrasound system
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Spinal Cord Injuries (SCI)
Hypoxia Pathways for Early Recovery After Spinal Cord Injury
Spinal cord injury (SCI) disrupts neural pathways to respiratory motor neurons, diminishing breathing capacity and airway defense (e.g., cough).
- Trial name
- HyPER-FLO (NCT07002437)
- Testing
- Augmented Acute Intermittent Hypoxia (aAIH), Acute Intermittent Hypercapnic-Hypoxia (AIHH)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Stroke
Focal Muscle Vibration and tDCS on Motor Recovery in Stroke
Although tDCS and FV have shown some benefit as stand-alone treatment, researcher suggest that combining intervention with complementary mechanism can lead to additive or synergistic benefits which might yield more significant…
- Trial name
- NCT06893653
- Testing
- Focal muscle vibration, tDCS, Physical Therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Long COVID
Water-based Activity to Enhance Recovery in Long COVID-19
This two-year study will evaluate the feasibility and safety of an exercise + cognitive training program to improve neurological symptoms of long-COVID.
- Trial name
- NCT06142253
- Testing
- WATER+CT, Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Stroke
Effect of Motor Imagery With Virtual Reality in Patients With Stroke
Virtual reality applications in hemiplegia rehabilitation are gaining popularity. It is claimed that, apart from implementing a function, imagining that function can trigger synaptic connections.
- Trial name
- NCT04215679
- Testing
- Three-dimensional immersive virtual reality application, Motor imagery, Conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Abant Izzet Baysal University
Hemiplegia and/or Hemiparesis Following Stroke
The Effect of Good Limb Position Management Assistive Devices on Preventing Shoulder Subluxation in Hemiplegic Patients
Stroke is a leading cause of long-term disability worldwide. During the early stage of recovery after cerebral infarction, reduced muscle tone and muscle weakness in the affected upper limb may lead to shoulder instability and…
- Trial name
- NCT07675759
- Testing
- Commercially Available Shoulder Sling, Novel Shoulder Subluxation Prevention Orthosis
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Covid19
Physical Activity and Smell Trainings to Help Individuals With Coronavirus Disease (COVID-19) Recover From Persistent Smell and Taste Impairments - A Pilot Study
The primary objective of this study is to identify efficient treatments to help those with chemosensory losses due to Coronavirus disease (COVID-19).
- Trial name
- CAPS (NCT05037110)
- Testing
- Physical activity, Smell training
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Université de Montréal
Healthy
The Investigators Conducted a Study to Examine the Impact of Wild Ginseng Extract (WG) on Exercise Performance, Cognitive Function, and Fatigue Recovery Among Twelve Healthy Adult Males
The goal of this clinical trial was to learn if Wild Ginseng extract (WG) influences exercise performance, cognitive function, and fatigue recovery from the exercise.
- Trial name
- NCT06679725
- Testing
- Wild ginseng extract
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Texas A&M University San Antonio
Ictus, Severe Acquired Brain Injury
Personality Traits as a Variable in the Recovery of Patients With Acquired Brain Injury
This study aims to evaluate the potential effects of premorbid personality on the short- and long-term global cognitive recovery in patients with severe acquired brain injury (sABI) or stroke.
- Conditions
- Ictus, Severe Acquired Brain Injury, sABI
- Trial name
- NCT07119827
- Testing
- Motor, cognitive and psychological assessment
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Universita di Verona
Stroke
Effects of Priming Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery After Stroke: A Randomized Controlled Trial
The aim of this study is to investigate the effects of intermittent theta burst stimulation primed with continous theta burst stimulation (cTBS), on top of a standard robot-assisted training (RAT) on improving the upper limb…
- Trial name
- NCT04034069
- Testing
- Theta burst stimulation (TBS), Robot-assisted training
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- The Hong Kong Polytechnic University
Cerebrovascular Disease; Sequelae
Machines Assisting Recovery From Stroke
Locomotor disability remains a major obstacle to community function in stroke survivors. This disability is best characterized by the reduced gait speed and enhanced risk of falls that is observed in the majority of stroke…
- Trial name
- MARS (NCT02787694)
- Testing
- Factor Targeted Walking Training, treadmill
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham
Neurological Disease, Motor Disorders
Technological Devices and Home Automation System in Neurological Rehabilitation
The use of home automation system may be useful in rehabilitation to collect data about the environment and the amount of therapy.
- Trial name
- SMART (NCT06270420)
- Testing
- Technological Motor Rehabilitation
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Hemiplegic Cerebral Palsy, Motor Activity
Action Observation Based Rehabilitation of Children With Unilateral Cerebral Palsy
Recent evidence suggested that Action Observation Therapy (AOT), based on observation of actions followed by immediate reproduction, could be a useful rehabilitative strategy for promoting functional recovery of children affected…
- Trial name
- NCT04088994
- Testing
- AOT Pathological Model Experimental Group, AOT Healthy Model Control Group
- Where
- Italy
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Parma
Cerebrovascular Accident
Hybrid Approach to Mirror Therapy and Transcranial Direct Current Stimulation for Stroke Recovery
We hypothesize that (1) the hybrid therapy will induce greater improvements on some health-related outcomes compared to other therapies; (2) such benefits will retain at 6-month follow-up; (3) better motor control and brain…
- Trial name
- NCT02254616
- Testing
- Mirror Therapy with tDCS, Mirror Therapy, Control Intervention
- Where
- 4 sites in Taiwan
- Volunteers
- 24 people
- Sponsor
- Chang Gung Memorial Hospital
Spinal Cord Injury, Spinal Cord Injury Subacute
Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury
Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (< 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to…
- Conditions
- Spinal Cord Injury, Spinal Cord Injury Subacute, Locomotion, Gait Disorder, Sensorimotor
- Trial name
- CIMELocomotion (NCT07375745)
- Testing
- Protocol 2: Gait training combined with an effective tSCS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Ischemic Stroke
Individual Alpha Frequency-Based rTMS for Post-Stroke Motor Recovery: Efficacy and Neurophysiological Mechanisms
The goal of this clinical trial is to evaluate the efficacy of a personalized brain stimulation technique, Individual Alpha Frequency (IAF)-based rTMS, for motor function recovery in adult patients with a first-ever ischemic…
- Trial name
- NCT07498777
- Testing
- Active Individual Alpha Frequency-based Repetitive Transcranial Magnetic Stimulation (IAF-rTMS)
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- National Taiwan University Hospital
Ischemic Stroke
MSC Secretome and rTMS for Motor Recovery After Subacute Ischemic Stroke
This randomized, double-blind, controlled clinical trial evaluates the effectiveness and safety of combined mesenchymal stem cell (MSC) secretome and repetitive transcranial magnetic stimulation (rTMS) for motor recovery in…
- Trial name
- NCT07874269
- Testing
- Mesenchymal Stem Cell-Derived Secretome, Active Repetitive Transcranial Magnetic Stimulation
- Where
- Indonesia
- Volunteers
- 205 people
- Sponsor
- Jumraini Tammasse