Clinical trials: Motor Recovery
Acute Stroke
IMAS Optimization and Applicability in Acute and Subacute Stroke.
The investigator will investigate our Integrated sensor-based Motion Analysis Suite (IMAS) to objectively and quantitatively measure acute stroke patient motor status.
- Trial name
- NCT05469438
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Case Western Reserve University
Stroke, Exercise
Addressing Arm Non-use by Encouraging Idle-time Activity During Early Recovery From Stroke
This project evaluates the feasibility of using custom wearable technology and associated procedures to increase activity of the more-involved upper extremity during the earliest stages of recovery from stroke by increasing the…
- Trial name
- NCT05900999
- Testing
- Feasibility of idle time exercise
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Marquette University
Long QT Syndrome, Cardiac Repolarization
Effect of Beta-blocker Therapy on QTc Response in Exercise and Recovery in Normal Subjects
Background. In congenital long QT syndrome type 1 (LQT1), episodes of ventricular tachycardia are usually triggered by exercise and can be prevented in most patients by beta-blocker therapy.
- Trial name
- NCT00588965
- Testing
- Propranolol LA
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Brain Infarction, Brain Ischemia
Transcranial Direct Current Stimulation, Improve Functional Motor Recovery, Affected Arm
Overall goal of this study is to determine if transcranial direct current stimulation (tDCS) plus conventional occupational therapy improves functional motor recovery in the affected arm-hand in patients after an acute ischemic…
- Trial name
- NCT01201629
- Testing
- t DC stimulation, tDCStimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Oklahoma
Long COVID, Long Covid19
RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM))
This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06404073
- Testing
- Structured Pacing, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Ischemic Stroke
Electric Field Navigated 1hz Rtms for Post-stroke Motor Recovery Trial
A prospective, multi-center, randomized, sham-controlled, blinded study combining active Nexstim NBS-guided 1Hz rTMS or sham-rTMS targeting the healthy hemisphere with standardized task oriented rehabilitation will be conducted…
- Trial name
- E-FIT (NCT03010462)
- Testing
- Nexstim NBS guided active rTMS
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Nexstim Ltd
Chronic Stroke
Brain Stimulation and Robotics in Chronic Stroke Motor Recovery
Motor skill training and transcranial direct current stimulation (tDCS) have separately been shown to alter cortical excitability and enhance motor function in humans.
- Trial name
- NCT03562663
- Testing
- Transcranial direct current stimulation, Upper extremity robotics
- Volunteers
- 82 people
- Sponsor
- Burke Medical Research Institute
Stroke, Stroke Sequelae
Noninvasive VNS to Facilitate Excitability in Motor Cortex
Transcranial Magnetic Stimulation (TMS) positively influences motor rehabilitation in stroke recovery. Transcutaneous auricular vagus nerve stimulation (taVNS) has shown effects on cortical plasticity.
- Conditions
- Stroke, Stroke Sequelae, Motor Activity
- Trial name
- NCT04130646
- Testing
- Transcranial Magnetic Stimulation, transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Stress Disorders, Post-Traumatic
Increasing Activity for Veterans With PTSD
The proposed work will be a key step forward in fulfilling the mission of VA RR\&D to restore function and enable social reintegration for Veterans.
- Trial name
- I CARE for Vet (NCT04383496)
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Stroke, Brain Infarction
Arm Rehabilitation Study After Stroke
This study is about arm and hand recovery after a stroke. The investigators are testing an experimental arm therapy called Accelerated Skill Acquisition Program (ASAP) which combines challenging, intensive and meaningful practice…
- Conditions
- Stroke, Brain Infarction, Brain Ischemia, Cerebral Infarction
- Trial name
- ICARE (NCT00871715)
- Testing
- Accelerated Skill Acquisition Program (ASAP), Dose-Equivalent Usual & Customary Care - DEUCC, Usual and Customary Care - UCC
- Where
- 8 sites in United States
- Volunteers
- 361 people
- Sponsor
- University of Southern California
Concussion, Brain
Salivary Biomarkers for Concussion Recovery
The overarching purpose of this proposed research is to determine whether BDNF and/or specific miRNAs can serve as biomarkers for recovery from a concussion during prescribed exercise.
- Trial name
- NCT05379920
- Testing
- High Volume Aerobic Exercise, Low Volume Aerobic Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Stroke, Cerebrovascular Accident (CVA)
Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke
The purpose of this study is to evaluate if multiple therapy sessions of Transcutaneous Vagus Nerve Stimulation (tVNS) combined with robotic arm therapy lead to a greater functional recovery in upper limb mobility after stroke…
- Conditions
- Stroke, Cerebrovascular Accident (CVA), Hemiparesis
- Trial name
- tVNS (NCT03592745)
- Testing
- Transcutaneous Vagus Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Northwell Health
Cerebrovascular Stroke
Fast Arm Motor Skill Training in Chronic Stroke Survivors
Every year, almost 800,000 people experience a stroke in the United States, which lead to upper-limb impairments, making recovery of motor function a priority in stroke rehabilitation.
- Trial name
- FAST (NCT05013762)
- Testing
- Fast intervention, Active Monitoring
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Southern California
Dyspnea, Lactic Acidosis
Effect of High Velocity/Hyperoxic Breathing Therapy on Blood Lactate Decline
The study will evaluate the impact of high velocity therapy (HVT) on reduction of work of breathing (as implied by breath frequency) and enhanced blood lactate decline during recovery from a Wingate-type Exercise test.
- Conditions
- Dyspnea, Lactic Acidosis, Muscle, Breathlessness
- Trial name
- NCT05984186
- Testing
- High Velocity Therapy
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vapotherm, Inc.
Caloric Restriction, Exercise
Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery
The objective of this study is to determine whether maintaining a eugonadal state, during severe, sustained energy deficit, attenuates physiological decrements, particularly the loss of lean body mass.
- Trial name
- OPS (NCT02734238)
- Testing
- Sesame Oil, testosterone enanthate
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Traumatic Brain Injury
Transcranial Direct Current Stimulation (tDCS) and Motor Training for Traumatic Brain Injury (TBI) Survivors
The aim of this study is to compare the effect of transcranial direct current stimulation and functional upper extremity task training to functional upper extremity task training alone.
- Trial name
- NCT01749735
- Testing
- Transcranial Direct Current Stimulation, Armeo training
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Spaulding Rehabilitation Hospital
Stroke
Upper Arm Training With Armeo Spring for Stroke
The purpose of this study is to assess the clinical outcomes of upper extremity training using the Armeo Spring system in a chronic post-stroke population with impaired upper extremity function.
- Trial name
- NCT01485354
- Testing
- Armeo Spring training
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Spaulding Rehabilitation Hospital
Stroke, Cerebrovascular Accident
Non-invasive Brain Stimulation and Occupational Therapy To Enhance Stroke Recovery
The purpose of this study is to determine whether a non-painful, non-invasive, brain-stimulation technique called transcranial direct current stimulation (tDCS) combined with traditional physical-occupational therapy (OT) will…
- Conditions
- Stroke, Cerebrovascular Accident, CVA, Acute Stroke
- Trial name
- TDCS+OT (NCT00792428)
- Testing
- Real Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Parkinson's Disease
Long-term Extension of RECOVER- Long-term Effect of the 24h Transdermal Delivery of Rotigotine in Subjects With Idiopathic Parkinson's Disease
The objective of this open-label extension is to assess the long-term effect of the 24-hour transdermal delivery of rotigotine on motor function, sleep quality, and nocturnal and non-motor symptoms of Parkinson's disease.
- Trial name
- NCT00519532
- Testing
- Rotigotine
- Where
- 21 sites in United States, Australia and 9 more
- Volunteers
- 84 people
- Sponsor
- UCB Pharma
Stroke
Fall-recovery Training for Those With Chronic Stroke and Low Falls Self-efficacy
Chronic stroke is the leading cause of long-term disability in the United States. Post-stroke health is negatively impacted by two interrelated factors-a substantial risk of falls and limited walking activity.
- Trial name
- NCT04112173
- Testing
- perturbation-based fall-recovery training
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Delaware