Clinical trials: Mountain Sickness
Acute Mountain Sickness
Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness
Acute mountain sickness (AMS) is a common condition that can occur when healthy people travel quickly to high altitude. Typical symptoms include headache, nausea, tiredness, dizziness, and poor sleep.
- Trial name
- NCT07653516
- Testing
- Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Mountain Sickness
HighCycle Study: Effect of High Altitude on Acute Mountain Sickness in Women Related to Their Menstrual Cycle Phase
Prospective cohort study investigating the menstrual cycle phase (MCP)-dependent incidence of acute mountain sickness (AMS) in women travelling to 3600 m.
- Trial name
- NCT06499714
- Testing
- Exposure to 3600 m
- Where
- Kyrgyzstan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypoxemia, Acute Mountain Sickness (AMS)
The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude
High altitude travel can lead to inflammation in the body and activation of innate immune cells. The investigators' prior research demonstrates that 1 to 3 days at 3800 m elevation leads to increased expression of genes in blood…
- Conditions
- Hypoxemia, Acute Mountain Sickness (AMS), Inflammation, Immune Response
- Trial name
- NCT07517068
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Hypoxia, Altitude Hypoxia
The Psychophysiological Effect of Simulated and Terrestrial Altitude
The aim of this study is to compare the psychophysiological effects of terrestrial altitude with a normobaric, hypoxic situation.
- Conditions
- Hypoxia, Altitude Hypoxia, Altitude Sickness, Altitude
- Trial name
- Hypoxia (NCT04075565)
- Testing
- Terrestrial altitude, Cloud 9
- Where
- 3 sites in Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Hypothermia, Hypoxia
Pharmacologic Induction of Tolerance for Hypoxia & Hypothermia
Warfighter Performance Optimization in Extreme Environments remains an area of important and intense investigation, with the following goals: (1) Optimize, sustain and augment medical readiness and physiological/ psychological…
- Conditions
- Hypothermia, Hypoxia, Mountain Sickness
- Trial name
- PhITHy-Ho (NCT06129825)
- Testing
- Prospective
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Acute Mountain Sickness
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
Millions of people travel to high altitude for work or leisure activities and are exposed to reduced inspiratory oxygen partial pressure and hypoxemia that may lead to altitude illness, among which the most common form is acute…
- Trial name
- NCT06499727
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Mountain Sickness (AMS)
Efficacy of Positive Expiratory Pressure on Acute Mountain Sickness
This pilot study aims to evaluate the efficacy of positive expiratory pressure (PEP) therapy at 10 cmH₂O in improving peripheral oxygen saturation (SpO₂) and mitigating symptoms of acute mountain sickness (AMS) in healthy…
- Trial name
- NCT07148674
- Testing
- Positive Expiratory Pressure (10cmH2O) in hypobaric hypoxia
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- BiALP - Alpine, Disaster and Wilderness Medicine
Acute Mountain Sickness
Voluntary Isocapnic Hyperpnea in Hypoxia to Mitigate Acute Mountain Sickness
This study investigates the effects of a brief Voluntary Isocapnic Hyperpnoea (VIH) on Acute Mountain Sickness (AMS) symptoms, SpO₂, blood pressure, and blood gas homeostasis in normobaric hypoxia, to evaluate whether such…
- Trial name
- NCT07126834
- Testing
- VIH
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Sport - National Research Institute, Poland
High Altitude Effects, High Altitude Hypoxia
HighCycle Study: Acetazolamide, High Altitude and Plasma Volume
Each year, millions of people living at low altitude (< 1,000 m) travel to high altitude (≥ 2,500 m) for work, tourism, or sports activities.
- Conditions
- High Altitude Effects, High Altitude Hypoxia, Acute Mountain Sickness (AMS), Plasma Volume
- Trial name
- NCT07118462
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Acute Mountain Sickness, High Altitude
CO2 Supplement for Treatment of Acute Mountain Sickness
It was reported that up to 76% people who rapidly ascend to the altitude higher than 4500 m without sufficient acclimatization will have AMS which often develops 6-8 hours after reaching at high altitude.
- Conditions
- Acute Mountain Sickness, High Altitude, Inhalation; Gas
- Trial name
- NCT06393998
- Testing
- Breathing with CO2 during daytime and night at high altitude, Sleep and doing exercise test under inhalation of air
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
Acute Mountain Sickness
Prochlorperazine Maleate Versus Placebo for the Prophylaxis of Acute Mountain Sickness
This study is a trial looking at a drug to help prevent acute mountain sickness. The drug is prochlorperazine, a drug commonly used to treat nausea vomiting and headache.
- Trial name
- NCT06450899
- Testing
- Prochlorperazine Maleate
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Mountain Sickness (AMS)
Safety and Efficacy of T89 in the Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)
The specific aim of this double blind, randomized phase III trial is to evaluate the safety and efficacy of T89 in preventing Acute Mountain Sickness (AMS) and relieving the symptoms of AMS after rapid ascent.
- Trial name
- NCT04993729
- Testing
- T89 capsule
- Where
- 3 sites in United States, China
- Volunteers
- 853 people, healthy volunteers welcome
- Sponsor
- Tasly Pharmaceuticals, Inc.
Acute Mountain Sickness
EleVation carE: a Randomized Controlled Trial on the Prevention of Acute Mountain Sickness With Suxiao Jiuxin Pill
The aim of this randomized, controlled trial is to evaluate the safety and efficacy of Suxiao Jiuxin Pills for prevention of acute mountain sickness (AMS) after high altitude exposure in healthy volunteers, and its influences on…
- Trial name
- EVEREST (NCT06531161)
- Testing
- Suxiao Jiuxin Pill
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Acute Mountain Sickness, High Altitude Pulmonary Edema
Risk Factors Associated With High Altitude Sickness: A Case-Control Study
Research Title: RISK FACTORS ASSOCIATED WITH HIGH ALTITUDE SICKNESS: A CASE-CONTROL STUDY Rationale: The Study will help us to identify risk factors of high altitude sickness among Nepalese and International patients.
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- NCT06039475
- Where
- Nepal
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
AMS, Acute Mountain Sickness
Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness
A field-based trial was conducted to determine if oral prochlorperazine demonstrates efficacy in the prophylactic treatment of AMS, and/or decreases the incidence of the symptoms of acute mountain sickness including headache, GI…
- Trial name
- PAMS (NCT06310642)
- Testing
- Immediate descent from altitude., Diphenhydramine, Prochlorperazine 10 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CHRISTUS Health
Acute Mountain Sickness
The Effect of Continuous Positive Pressure Ventilation on Symptoms of Acute Mountain Sickness
Acute Mountain Sickness (AMS) is a common condition affecting individuals traveling to elevations greater than 2500 meters (8200 feet).
- Trial name
- NCT06145113
- Testing
- Continuous positive airway pressure (CPAP), ResMed AirMini
- Where
- Nepal
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
High Altitude, Inhalation; Gas
Effect of Inhalation of Low Dose CO2 on Exercise Performance at High Altitude
High altitude (>2400 m) is associated with decreased atmosphere pressure leading to hypoxia which in turn impairs exercise capacity and causes acute mountain sickness (AMS).
- Conditions
- High Altitude, Inhalation; Gas, Acute Mountain Sickness
- Trial name
- NCT05798416
- Testing
- Exercise under inhalation CO2, Exercise under inhalation ambient air
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
Acute Mountain Sickness
The Effects of Intermittent Hypoxia on Acute Hypoxic Injury
This study intends to further reveal the effectiveness of intermittent hypoxia in preventing acute hypoxic injury.
- Trial name
- NCT05733338
- Testing
- Intermittent Hypoxia
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Acute Mountain Sickness
Colorado-Oregon Altitude Study
Investigating the utility of prophylactic treatment with iron sucrose and/or erythropoietin on the prevention of acute mountain sickness in fit, young, healthy individuals.
- Trial name
- COAST (NCT05734716)
- Testing
- Erythropoietin, Iron sucrose (Venofer), Sterile Sodium Chloride
- Where
- 2 sites in United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine