Clinical trials: Mountain Sickness
Acute Mountain Sickness
Drug Combination on Exercise Performance at High Altitude
This study is being conducted to determine the effectiveness of using two FDA approved medications in concert to reduce the likelihood of sickness due to low oxygen levels and to reduce the decrement in physical performance at…
- Trial name
- NCT01902758
- Testing
- ambrisentan and theophylline
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Montana
Altitude Hypoxia
Effect of Acetazolamide on Maximal Exercise Performance in Lowlanders Older Than 40 Years at Altitude
Randomized, placebo controlled trial evaluating the effect of acetazolamide on maximal exercise performance in lowlanders older than 40 years travelling from 760 m to 3'100 m.
- Trial name
- NCT03536455
- Testing
- ACETAZOLAMIDE oral capsule
- Where
- Kyrgyzstan
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Mountain Sickness (AMS)
Evaluation of the Prevention and Treatment Effects of Chinese Medicine on High Altitude Illness
This trial is aimed to evaluate the effects of "Wu Zhu Yu Tang" on the prevention of Acute Mountain Sickness(AMS).
- Trial name
- NCT01682551
- Testing
- Chinese Medicine, Acetalozamide
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
High Altitude Pulmonary Edema
Comparison of CPAP and Gamow Bag Ventilation to Treat HAPE
High altitude pulmonary edema (HAPE) is mostly treated with supplemental oxygen, nifedipine 30mg twice a day, rest, limiting cold exposure and descent (simulated or actual) Gamow Bag provides simulated descent and buy time for…
- Trial name
- CPAP (NCT04710953)
- Testing
- Continuous positive airway pressure machine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- sultan mehmood kamran
Acute Mountain Sickness
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
Millions of people travel to high altitude for work or leisure activities and are exposed to reduced inspiratory oxygen partial pressure and hypoxemia that may lead to altitude illness, among which the most common form is acute…
- Trial name
- NCT06499727
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pulmonary Hypertension
Acute Exposure to High Altitude on Exercise Capacity
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) in constant loaded exercise capacity.
- Trial name
- NCT03637153
- Testing
- Assessment at Low Altitude (470m above sea level), Exposure to High Altitude (2500m above sea level)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Acute Mountain Sickness, High Altitude Pulmonary Edema
Hemodynamic Changes in Altitude Adaptation
We use a new technology (Nexfin from BMEYE-Inventive Hemodynamics) to monitor Cardiac Output, Blood Pressure, Fluid Responsiveness, Pulse Oximetry, Hemoglobin Concentration, Oxygen Delivery in Climbers during their process of…
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- NCT01698619
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Goethe University
Right Heart Function, Chronic Obstructive Pulmonary Disease
Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude
The purpose of this randomized, placebo-controlled double-blind trial is to evaluate the effect of acetazolamide on right heart function at rest in lowlanders with chronic obstructive pulmonary disease (COPD) traveling to high…
- Conditions
- Right Heart Function, Chronic Obstructive Pulmonary Disease, Altitude Sickness
- Trial name
- NCT04915365
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Critical Congenital Heart Disease, High Altitude
Oxygen Saturation and Perfusion Index ın Neonates at High Altitude
Congenital heart diseases are among the most common congenital anomalies and occur with an incidence of approximately 8ınd12 / 1,000 live births worldwide.
- Trial name
- NCT04290481
- Testing
- oxygen saturation and perfusion index screening
- Where
- Turkey (Türkiye)
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Exercise-induced Bronchoconstriction (EIB)
Hypoxic Environment on EIB and Performance in Race Walkers
Title: Diagnosis and Impact of Exercise-Induced Bronchoconstriction (EIB) in Athletes During Altitude Training Study Description: We invite you to participate in a research study examining Exercise-Induced Bronchoconstriction…
- Trial name
- EIB-H (NCT07466849)
- Testing
- High-Altitude Training & Hypoxic Environment Exposure
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Sport
Hypoxia Altitude Simulation Test, High Altitude
Hypoxia-altitude Testing to Predict Altitude Related Adverse Health Effects in Chronic Obstructive Pulmonary Disease (COPD) Patients
The predictive value of the hypoxia altitude simulation test (HAST) or other baseline values to predict altitude-related adverse health effects (ARAHE) is not established.
- Trial name
- NCT04915378
- Testing
- hypoxia altitude simulation test (HAST) at 760m, High Altitude (3100m)
- Where
- Kyrgyzstan
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in patients with pulmonary…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude Effects, High Altitude
- Trial name
- NCT07804576
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Pulmonary Hypertension, Mountain Sickness
Study of the Effects of Iron Levels on the Lungs at High Altitude
The study hypothesis is that body iron levels are important in determining the increase in lung blood pressure that occurs in response to low oxygen levels.
- Trial name
- NCT00952302
- Testing
- Iron sucrose, Normal saline, Venesection
- Where
- Peru
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Mountain Sickness, Chronic
Chronic Mountain Sickness, Systemic Vascular Function
Diseases associated with chronic hypoxemia like chronic obstructive pulmonary disease (COPD) or emphysema, represent major medical and socio-economical problems and one of the leading cause of morbidity and mortality in the…
- Trial name
- CMS (NCT01182792)
- Testing
- Vitamin C and E
- Where
- 2 sites in Bolivia, Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Hypoxia, Altitude
Treatment of Chronic Mountain Sickness
This study aims to assess the effect of two drugs for the treatment of chronic mountain sickness in highlanders.
- Trial name
- Exp5300 (NCT04251364)
- Testing
- Acetazolamide, Atorvastatin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Healthy
Hypoxia Impairs Endothelial Function in HAPEs
Aim of the study is to investigate the function of the systemic vascular endothelium in individuals susceptible to high-altitude pulmonary oedema during normoxia and normobaric hypoxia.
- Trial name
- NCT00176007
- Testing
- Hypoxia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Heidelberg University
Acute Mountain Sickness
Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort
Commercial aircraft passengers are exposed to atmospheric pressures ranging from the pressure found at ground level to that encountered in the external environment at 8,000 feet.
- Trial name
- NCT00326703
- Testing
- Hypobaric hypoxia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Boeing Company
Pulmonary Hypertension
Acute Exposure to High Altitude on Blood and Tissue Oxygenation (ABGA, NIRS)
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) on blood and tissue oxygenation (ABGA, NIRS).
- Trial name
- NCT03600415
- Testing
- Low altitude: 470m above sea level, Säntis; 2500m above sea level
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Healthy, Healthy Adult
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Healthy Individuals
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in healthy individuals, who live…
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07804537
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Environmental Sleep Disorder, Cheyne-Stokes Respiration
Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude
One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration.
- Conditions
- Environmental Sleep Disorder, Cheyne-Stokes Respiration, Altitude Sickness
- Trial name
- PerOxySleep (NCT01465971)
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Goethe University