Clinical trials: Mountain Sickness Acute
Pulmonary Hypertension
Acute Exposure to High Altitude on Exercise Capacity
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) in constant loaded exercise capacity.
- Trial name
- NCT03637153
- Testing
- Assessment at Low Altitude (470m above sea level), Exposure to High Altitude (2500m above sea level)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Altitude Hypoxia, Hypoxia
Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.
More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland.
- Conditions
- Altitude Hypoxia, Hypoxia, Normobaric Hypoxia, Right Ventricular Function
- Trial name
- RIVER-HAPE (NCT07431554)
- Testing
- Normobaric Hypoxia
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Mona Lichtblau
Acute Mountain Sickness
Erythropoietin in the Prevention of Acute Mountain Sickness
Acute mountain sickness (AMS) is a syndrome of nonspecific symptoms and is therefore subjective. The Lake Louise Consensus Group defined acute mountain sickness as the presence of headache in an unacclimatized person who has…
- Trial name
- EPO-AMS (NCT01665781)
- Testing
- Erythropoietin
- Where
- South Korea
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Ulsan
Acute Mountain Sickness, High Altitude Pulmonary Edema
Hemodynamic Changes in Altitude Adaptation
We use a new technology (Nexfin from BMEYE-Inventive Hemodynamics) to monitor Cardiac Output, Blood Pressure, Fluid Responsiveness, Pulse Oximetry, Hemoglobin Concentration, Oxygen Delivery in Climbers during their process of…
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- NCT01698619
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Goethe University
Ketosis, Hypoxia
Intermittent Exogenous Ketosis (IEK) at High Altitude
Altitude-related hypoxia decreases human functional capacity, especially during exercise. Even with prolonged acclimatization, the physiological adaptations are insufficient to preserve exercise capacity, especially at higher…
- Trial name
- NCT06097754
- Testing
- Ketone ester
- Where
- 2 sites in Belgium, Slovenia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Acute Mountain Sickness, Environmental Illness
Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness
Traditional folk medicine in the Arctic and Himalayan areas used Rhodiola species to enhance physical endurance, prevent aging, resist acute mountain sickness (AMS), and to treat fatigue, depression, anemia, impotence and…
- Trial name
- NCT01536288
- Testing
- Rhodiola crenulata
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Acute Mountain Sickness
EleVation carE: a Randomized Controlled Trial on the Prevention of Acute Mountain Sickness With Suxiao Jiuxin Pill
The aim of this randomized, controlled trial is to evaluate the safety and efficacy of Suxiao Jiuxin Pills for prevention of acute mountain sickness (AMS) after high altitude exposure in healthy volunteers, and its influences on…
- Trial name
- EVEREST (NCT06531161)
- Testing
- Suxiao Jiuxin Pill
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Acute Mountain Sickness, High Altitude Pulmonary Edema
Sleep and Cerebral Responses to High Altitude
Mechanisms underlying high-altitude intolerance as well as exercise performance limitation in hypoxia still remain to be fully understood.
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- VALLOT 2011 (NCT01565603)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Hypoxia, Altitude, Brain
The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.
Background: Vaso-active polyphenols have been proposed to enhance cognitive performance. Oral administration with the non-flavonoid polyphenol, resveratrol, has been found to modulate cerebral blood flow (CBF); yet, this has not…
- Trial name
- NCT03541993
- Testing
- Resveratrol
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Acute Mountain Sickness
Prochlorperazine Maleate Versus Placebo for the Prophylaxis of Acute Mountain Sickness
This study is a trial looking at a drug to help prevent acute mountain sickness. The drug is prochlorperazine, a drug commonly used to treat nausea vomiting and headache.
- Trial name
- NCT06450899
- Testing
- Prochlorperazine Maleate
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Mountain Sickness
Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages
This double blind randomized trial will compare acetazolamide taken the morning of ascent to acetazolamide taken the evening prior to ascent for the prevention of acute mountain sickness (AMS).
- Trial name
- SEAWARD (NCT03424226)
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Mountain Sickness (AMS)
Efficacy of Positive Expiratory Pressure on Acute Mountain Sickness
This pilot study aims to evaluate the efficacy of positive expiratory pressure (PEP) therapy at 10 cmH₂O in improving peripheral oxygen saturation (SpO₂) and mitigating symptoms of acute mountain sickness (AMS) in healthy…
- Trial name
- NCT07148674
- Testing
- Positive Expiratory Pressure (10cmH2O) in hypobaric hypoxia
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- BiALP - Alpine, Disaster and Wilderness Medicine
Environmental Sleep Disorder, Cheyne-Stokes Respiration
Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude
One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration.
- Conditions
- Environmental Sleep Disorder, Cheyne-Stokes Respiration, Altitude Sickness
- Trial name
- PerOxySleep (NCT01465971)
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Goethe University
Hypoxia, Altitude
Colour Vision Impairment During Acute Hypobaric Hypoxia
This study analyses the impairment of colour vision during hypobaric hypoxia in volunteers of different groups.
- Trial name
- NCT05584813
- Testing
- Hypobaric Hypoxia
- Where
- Germany
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Köln
High-altitude Sleep Disturbance
Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude
More than 70% of visitors to high altitude suffer poor sleep. The present study seeks to answer the question: Which medication is associated with better sleep at high altitude: temazepam or acetazolamide? The investigators…
- Trial name
- NCT01519544
- Testing
- Temazepam, Acetazolamide
- Where
- Nepal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pulmonary Hypertension
Acute Exposure to High Altitude on Blood and Tissue Oxygenation (ABGA, NIRS)
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) on blood and tissue oxygenation (ABGA, NIRS).
- Trial name
- NCT03600415
- Testing
- Low altitude: 470m above sea level, Säntis; 2500m above sea level
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Acute Mountain Sickness
The Effects of Intermittent Hypoxia on Acute Hypoxic Injury
This study intends to further reveal the effectiveness of intermittent hypoxia in preventing acute hypoxic injury.
- Trial name
- NCT05733338
- Testing
- Intermittent Hypoxia
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Hypoxia
The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia
The study will aim to describe and evaluate the effect of chronic beetroot juice supplementation on acute mountain sickness symptoms and exercise in a hypoxic environment.
- Trial name
- NCT03101904
- Testing
- Beetroot Juice
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Bangor University
Acute Mountain Sickness
Acclimatization Mechanisms During Ascent to 7500m
The trial evaluates the role of ascent protocol on acute mountain sickness and cardio-respiratory physiology during an ascent to Muztagh Ata (7546m).
- Trial name
- NCT00603122
- Testing
- ascent protocol
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pulmonary Hypertension
Acute Exposure of High Altitude on Cardiac Output
Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response High Altitude (Säntis; 2500m above sea level) on non-invasive cardiac output assessments by Finapres® NOVA Technology at…
- Trial name
- NCT03637218
- Testing
- Assessment at Low Altitude (470m above sea level), Exposure to High Altitude (2500m above sea level)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich