Clinical trials: Mouth Diseases
Adjuvant Chemotherapy, Colon Cancer
Modulation of Immune Response by Oral Zinc Supplementation in Chemotherapy for Colon Cancer
In leukocytes of patients undergoing adjuvant chemotherapy for colon cancer treatment: a)identify genes modulated by oral supplementation of zinc; b) evaluate the effects of oral zinc supplementation on humoral immunity and…
- Conditions
- Adjuvant Chemotherapy, Colon Cancer, Immunity
- Trial name
- NCT01261962
- Testing
- zinc
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Triple Negative Breast Cancer, Hepatocellular Carcinoma
A PD Study of Oral eFT508 in Subjects With Advanced TNBC and HCC
This study will evaluate the pharmacodynamic (PD), safety, antitumor activity, and PK of eFT508 in female subjects who have pathologically documented, radiographically measurable, metastatic or locally advanced and unresectable…
- Trial name
- NCT03318562
- Testing
- eFT508
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Effector Therapeutics
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases
This phase I trial studies the side effects and best dose of ropidoxuridine when given together with whole brain radiation therapy in treating patients with cancer that has spread to the brain (brain metastases).
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Brain
- Trial name
- NCT02993146
- Testing
- Laboratory Biomarker Analysis, Pharmacological Study, Quality-of-Life Assessment
- Where
- 14 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Steven-Johnson Syndrome, Toxic Epidermal Necrolysis
Severe Cutaneous Adverse Reactions in Thailand
The multicenter registry of patients with severe cutaneous adverse reactions among tertiary medical institutes in Thailand to study clinical characteristics, etiologies, therapeutic outcomes, quality of life, and the values of in…
- Conditions
- Steven-Johnson Syndrome, Toxic Epidermal Necrolysis, Drug Reaction With Eosinophilia and Systemic Symptoms, Acute Generalized Exanthematous Pustulosis
- Trial name
- ThaiSCAR (NCT02574988)
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Chulalongkorn University
Crohn's Disease
Safety and Efficacy of Oral BT-11 in Crohn's Disease Patients With Moderate to Severe Disease
This is a phase 2, randomized, double-blind, multicenter study to assess the therapeutic efficacy, safety, and mechanisms of omilancor (BT-11) in patients with moderate to severe Crohn's Disease (CD).
- Trial name
- NCT05057273
- Testing
- BT-11, Active comparator
- Sponsor
- NImmune Biopharma
Nutritional Support, Aerobic Exercise
Study on Pulmonary Rehabilitation for Stable Chronic Obstructive Pulmonary Disease(COPD) Patients
To compare the difference of effectiveness for stable COPD patients with poor nutritional status among three groups named health education, upper and lower limb exercises, and oral nutritional supplements.
- Conditions
- Nutritional Support, Aerobic Exercise, Respiratory Function Tests, Body Composition
- Trial name
- NCT04741373
- Testing
- oral nutritional supplements, rehabilitation exercise, health education
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fudan University
Genital Warts
Efficacy and Safety of Oral Ivermectin for Genital Warts
This study aims to evaluate the efficacy and safety of oral ivermectin in adults with recalcitrant genital warts that have not responded to conventional treatments.
- Trial name
- NCT07913321
- Testing
- Ivermectin
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- University of Health Sciences Lahore
Sarcopenia, Sjogren's Syndrome
Prevalence and Factors of Sarcopenia and in Patients With Primary Sjogren's Syndrome
Sarcopenia is a progressive condition characterized by decline in muscle strength and muscle mass. Although the mechanism of sarcopenia has not been fully elucidated, it may be caused by protein-poor diet, vitamin D deficiency…
- Conditions
- Sarcopenia, Sjogren's Syndrome, Rheumatologic Disease
- Trial name
- NCT05015114
- Testing
- Sarcopenia Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Acibadem University
HIV/AIDS
Safety and Pharmacokinetic Study of Oral Maraviroc and Maraviroc 1% Gel in HIV-1 Seronegative Adults
The purpose of the study is to evaluate the safety, acceptability, and PK/PD profile of maraviroc gel following rectal and vaginal administration. The study also includes oral exposure to maraviroc.
- Trial name
- NCT02346084
- Testing
- Maraviroc 300 mg tablet (PO) and Maraviroc 1% gel (PR and PV)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Tongue Cancer, Chemotherapy Effect
A Study of Tongue Conservation Surgery for Oral Tongue Cancer
This is an open-label, non-comparative phase II clinical trial to assess efficacy and safety of tongue conservation treatment with sequential induction chemotherapy, tongue conservation surgery and postoperative concurrent…
- Conditions
- Tongue Cancer, Chemotherapy Effect, Surgery
- Trial name
- NCT03161548
- Testing
- Induction chemotherapy, Tongue conservation surgery, postoperative CCRT
- Volunteers
- 23 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Infection, Human Immunodeficiency Virus
Dose-finding Study of GSK2248761 in Antiretroviral Therapy-Naive Subjects (SIGNET)
This 96 week, Phase 2b study in 150 HIV-1 infected antiretroviral (ART) naive adult subjects consists of a dose-ranging evaluation of GSK2248761 at blinded doses of 100 mg and 200 mg once daily with a control arm of open-label…
- Trial name
- SIGNET (NCT01231555)
- Testing
- GSK2248761 100 mg once daily, GSK2248761 200 mg once daily, Efavirenz 600 mg once daily
- Where
- 12 sites in France, Germany and 1 more
- Volunteers
- 23 people
- Sponsor
- ViiV Healthcare
Sedation, ICU
RemImazolam Besylate for ICU-sedation in Patients With Mechanical Ventilation After Oral and Maxillofacial Surgery
Remimazolam besylate, as a new benzodiazepine drug, showing rapid clearance and moderate distribution of pharmacokinetic changes.
- Conditions
- Sedation, ICU, Remimazolam Besylate
- Trial name
- NCT05606315
- Testing
- Remimazolam Besylate, Propofol, Midazolam
- Where
- 2 sites in China
- Volunteers
- 117 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Atrial Fibrillation New Onset, Myocardial Infarction
Standard Versus Intensive Monitoring After Myocardial Infarction Looking for Atrial Fibrillation
After a myocardial infarction (MI), patients discharged home in sinus rhythm may develop AF that is asymptomatic, undetected, and undertreated.
- Trial name
- SIMPL-AF (NCT03345615)
- Testing
- 30-day ambulatory cardiac event monitor
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University of British Columbia
Mucositis Oral
Evaluation of ONCOXIN® in Oral Mucositis, Appetite and Body Mass in Cancer Patients.
Oral mucositis is one of the most spread side effects of anticancer therapy. It is associated with both chemo- and radiotherapy, decreases QoL, relative dose intensity and leads to nutritive deficiency.
- Trial name
- NCT03577535
- Testing
- Oncoxin®
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Catalysis SL
Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML)
A Phase Ib Study of Panobinostat (LBH589) in Combination With 5-Azacitidine for Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML) or Acute Myeloid Leukemia (AML) Patients
The purpose of this study is to confirm the safety and tolerability of oral panobinostat (PAN) in combination with a fixed dose of 5-Azacitidine (5-Aza) in adult Japanese patients with Myelodysplastic Syndromes (MDS), Chronic…
- Conditions
- Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), Acute Myeloid Leukemia (AML)
- Trial name
- NCT01613976
- Testing
- Panobinostat
- Where
- 6 sites in Japan
- Volunteers
- 10 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes Mellitus
Study to Evaluate the Efficacy and Safety of ORMD-0801 in Subjects With Type 2 Diabetes Mellitus
In this randomized, double-blind, double-dummy, placebo-controlled study, approximately 675 eligible subjects with type 2 diabetes and inadequate control on at least one and up to 3 oral glucose-lowering agents will undergo an…
- Trial name
- NCT04606576
- Testing
- ORMD-0801 QD, ORMD-0801 BD
- Where
- United States
- Volunteers
- 710 people
- Sponsor
- Oramed, Ltd.
Temporomandibular Disorders (TMD)
Age and Gender in TMJ Sounds
The temporomandibular joint (TMJ) plays a crucial role in masticatory function, and its proper lubrication is essential for smooth, frictionless movement.
- Trial name
- NCT06871189
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Atlas University
Mucositis
Impact of Oral Hygiene Gels on Peri-implant Mucositis
Peri-implant mucositis is abnormal inflammation occurring around dental implants, increasing the risk of loss of bone support. The purpose of this study is to evaluate the impact of brushing the bacterial biofilm at the…
- Trial name
- NCT03243591
- Testing
- Livionex gel, Aquafresh gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Coronary Heart Disease, Periodontal Diseases
Expression of Trefoil Factors and Adrenomedullin in Subjects With Chronic Periodontitis and Coronary Heart Disease
To assess the demographic variables, periodontal parameters and to determine the expression of Trefoil factors 2 and 3 and Adrenomedullin in unstimulated saliva samples of periodontally healthy subjects with coronary heart…
- Trial name
- NCT04127474
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Leukemia
Dasatinib in Imatinib Resistant/Intolerant Chinese CML (Chronic and Advanced Phase) Subjects
The primary objective of this study is to estimate the major cytogenetic response (MCyR) rate to Dasatinib in subjects with CP CML, complete and overall hematologic response (CHR and OHR) rate in subjects with AD CML or Ph+ ALL…
- Trial name
- NCT00529763
- Testing
- Dasatinib
- Where
- 14 sites in China
- Volunteers
- 121 people
- Sponsor
- Bristol-Myers Squibb
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.