Clinical trials: Mouth Diseases
Overweight, Obesity
Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range
This study will look how well semaglutide tablets taken once daily helps people with body weight above the healthy range. Participants will either get semaglutide 25 milligram (mg) once daily or placebo once daily.
- Trial name
- OASIS 4 (NCT05564117)
- Testing
- Semaglutide
- Where
- 23 sites in United States, Canada and 2 more
- Volunteers
- 307 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Clinical Trial Comparing The Efficacy And Safety Of 2 Different Initial Dose Prescriptions For Exubera.
The primary objective of this study is to assess whether a simple initial dose prescription of inhaled insulin (Exubera) achieves glycemic control (HbA1c) after 16 weeks that is non-inferior compared to the standard weight-based…
- Trial name
- NCT00437489
- Testing
- Inhaled Human Insulin (Exubera)
- Where
- 9 sites in Hong Kong, Pakistan and 2 more
- Volunteers
- 49 people
- Sponsor
- Pfizer
Obstetric Labour, Premature
The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor
Pre-Term Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone produced by the body during labor.
- Trial name
- NCT00404768
- Testing
- GSK221149A
- Where
- 57 sites in United States, Argentina and 9 more
- Volunteers
- 93 people
- Sponsor
- GlaxoSmithKline
Peri-Implantitis and Peri-implant Mucositis
Peri-implant Vitamin D and Cathelicidin (LL-37) Levels
This research aims to explore the influence of vitamin D on the body's defense system by examining its impact on specific proteins involved in immune response and inflammation in the soft tissues surrounding dental implants.
- Trial name
- NCT06867250
- Testing
- The patients' periodontal clinical parameters were recorded. PISF samples were collected, and the evaluations of 25(OH)D and LL-37 were conducted using enzyme-linked immunosorbent assay.
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Altinbas University
Cancer, Nutrition Related Cancer
Study to Evaluate the Organoleptic Perception of Oral Nutritional Supplements for Oncological Patients
Nutritional therapy is key to helping cancer patients get the nutrients they need to maintain body weight, strength, tissue and organ integrity, and face likely infections.
- Conditions
- Cancer, Nutrition Related Cancer, Malnutrition
- Trial name
- SENSORIAL (NCT05488184)
- Testing
- Flavoured Oral Nutritional Supplement (ONS)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
NASH - Nonalcoholic Steatohepatitis, NAFLD
Assessment of the Safety of Foralumab, an Oral Anti-CD3 Antibody, in Patients With NASH and T2DM
This is a randomized, placebo-controlled, four-arm, double-blind study. Subjects will be randomized (1:1:1:1) to receive either a daily oral placebo solution or a daily oral dose of 0.5 mg, 2.5 mg or 5.0 mg Foralumab Solution for…
- Conditions
- NASH - Nonalcoholic Steatohepatitis, NAFLD, T2DM (Type 2 Diabetes Mellitus)
- Trial name
- NCT03291249
- Testing
- Foralumab, Omeprazole 20mg
- Sponsor
- Tiziana Life Sciences LTD
Asthma
Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma
Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adults with Oral Corticosteroid Dependent Asthma
- Trial name
- SOURCE (NCT03406078)
- Testing
- Tezepelumab
- Where
- 60 sites in United States, Argentina and 5 more
- Volunteers
- 150 people
- Sponsor
- AstraZeneca
Acute Otitis Media
A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media
The primary objective is to compare the safety and efficacy of cefdinir oral suspension, 7 mg/kg/day ql2hrs for 5 days, to amoxicillin/clavulanate oral suspension 45 mg/kg/day (based on amoxicillin component), in divided doses…
- Trial name
- NCT00644943
- Testing
- cefdinir (Omnicef), amoxicillin
- Where
- 32 sites in United States
- Volunteers
- 425 people
- Sponsor
- Abbott
Dental Caries in Children
Impact of Oral Health Program on Al-Lith Children's KAP
Dental caries remains a significant global public health issue, particularly affecting children's health, development, and well-being, with inadequate knowledge, attitudes, and practices around oral health exacerbating these…
- Trial name
- NCT07009015
- Testing
- The oral health education intervention program
- Where
- Malaysia
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Type II Diabetes Mellitus
A Clinical Study to Evaluate Safety, Tolerability and Pharmacokinetics of Oral HMS5552 in Healthy Volunteers
The objectives of this study is to determine the safety profiles, tolerability, pharmacokinetics and pharmacodynamics of HMS5552 following single ascending doses in healthy adult subjects.
- Trial name
- NCT01952535
- Testing
- HMS5552
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hua Medicine Limited
Periodontal Diseases, Dental Caries
Prevalence of Caries and Periodontal Disease and Their Correlation in a Dental School in Egypt
In Egypt, oral diseases such as caries and periodontal disease are particularly burdensome, with implications for overall health and quality of life.
- Trial name
- NCT07880808
- Testing
- Prevalence of caries and periodontal diseases
- Where
- Egypt
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Cairo University
Polyuria-polydipsia Syndrome
Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers
This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.
- Trial name
- Macicop (NCT03844217)
- Testing
- Macimorelin 0.5mg/kg body weight, Macimorelin 0.75mg/kg body weight
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Periodontitis (Disorder), Periodontitis
i-PRF & Root Surface Biomodification
This study is designed to evaluate a new method to improve healing in patients with gum disease (periodontitis). A total of 42 adults with gum pockets deeper than 5 millimeters will take part.
- Trial name
- iPRF-Perio (NCT07207668)
- Testing
- Open Flap Debridement (OFD), 24% EDTA Root Conditioning, Injectable Platelet-Rich Fibrin (i-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Halil Ata BIÇAKÇIOGLU
Hypertension in Pregnancy, Postpartum Preeclampsia
Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension
The purpose of this study is to see if a combined pill of Angiotensin-converting enzyme (ACE) inhibitors (a medication that helps relax your veins and arteries to lower your blood pressure) with diuretics (sometimes called water…
- Trial name
- ACE (NCT05049616)
- Testing
- ACE Inhibitors and Diuretics, NIFEdipine ER
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The University of Texas Health Science Center, Houston
Loss of Teeth Due to Extraction, Alveolar Bone Loss
Relate Tooth Alveolar Extraction Socket Anatomy to Alveolar Remodeling Rate
In patients that are going to be subjected to a tooth extraction in the anterior maxillary (from canine to canine) does the position of the intact alveolar socket related to maxillary basal bone interferes with the rate of…
- Conditions
- Loss of Teeth Due to Extraction, Alveolar Bone Loss, Bone Resorption
- Trial name
- NCT01963884
- Testing
- Tooth Extraction, Cone-Beam technology evaluation, Measure Alveolar Socket Remodeling
- Where
- Portugal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
Nosocomial Infections
Study of Talactoferrin Oral Solution for Nosocomial Infection in Preterm Infants
This study will evaluate the safety, toxicity and efficacy of talactoferrin in reducing the incidence of all nosocomial infections in prematurely-born infants.
- Trial name
- NCT00854633
- Testing
- Talactoferrin
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Agennix
Parathyroid Hormone
Study of Zemplar iv in Patients With End Stage Chronic Kidney Disease, Undergoing Haemodialysis
This is the post-marketing study conducted in two countries: Croatia and Serbia. In both countries Zemplar (paricalcitol) is the first injectable form of any Vitamin D Receptor (VDR) activator available for chronic kidney disease…
- Trial name
- NCT01084538
- Testing
- Zemplar iv (paricalcitol iv)
- Where
- 21 sites in Croatia, Serbia
- Volunteers
- 181 people
- Sponsor
- Abbott
Xerostomia
Interest of Auriculotherapy in the Treatment of Xerostomia
The aim of the study is to show that auriculotherapy is effective in the treatment of xerostomia
- Trial name
- AURICULOXERO (NCT04222478)
- Testing
- Specific auriculotherapy, Non-specific auriculotherapy
- Where
- 4 sites in France
- Volunteers
- 65 people
- Sponsor
- Hopital Foch
Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency, Carnitine Palmitoyltransferase Deficiency 2
Oral Ketones and Exercise Among Patients With Long-chain Fatty Acid Oxidation Disorders
The purpose of the study is to determine if an oral ketone beverage is safe and well-tolerated during moderate intensity exercise in participants with long-chain fatty acid oxidation disorders and if it will raise blood ketones…
- Conditions
- Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency, Carnitine Palmitoyltransferase Deficiency 2, Very Long Chain Acyl Coa Dehydrogenase Deficiency, Trifunctional Protein Deficiency
- Trial name
- NCT05411835
- Testing
- Nutritional Ketone Supplement
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Diarrhea, HIV Infections
A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Orally Administered SP-303 for the Treatment of Diarrhea in Acquired Immunodeficiency Syndrome (AIDS) Patients
To evaluate the efficacy, safety, and durability of response of SP-303 in decreasing stool weight in AIDS patients with diarrhea over 6 days of treatment.
- Trial name
- NCT00002408
- Testing
- Crofelemer
- Where
- 36 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- Shaman Pharmaceuticals
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