Clinical trials: Mouthwashes
Tooth Erosion
Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion
An in situ model will be used to evaluate and compare enamel remineralization of bovine enamel specimens.
- Trial name
- NCT01128972
- Testing
- Sodium fluoride, Sodium monoflurophosphate, Sterile water
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
A Study in Dentinal Hypersensitivity (DH) Participants to Assess the Efficacy of an Occluding Dentifrice.
This study will investigate the longitudinal efficacy of two experimental oral rinses, one containing 1.5% weight/weight (w/w) dipotassium oxalate monohydride (KOX) /0 Parts per Million (ppm fluoride) and the other 2.0% w/w KOX…
- Trial name
- NCT02753075
- Testing
- Experimental Oral Rinse 1, Experimental Oral Rinse 2, Fluoride toothpaste
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Xerostomia
A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water
This study assessed the efficacy of three dry mouth products (including an experimental Oralbalance gel, oral rinse, and moisturizing spray) to relieve the feeling of dry mouth compared to water, in dry mouth population over a…
- Trial name
- NCT03494985
- Testing
- Experimental Oralbalance Moisturizing Gel, Biotene Original Oral Rinse, Biotene Moisturizing Mouth Spray
- Volunteers
- 422 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tooth Stain
A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal
The whitening action of an investigative hydrogen peroxide/sodium fluoride containing mouth rinse will be evaluated through stain removal using mean Lobene Stain Index over 14 days compared to a currently marketed hydrogen…
- Trial name
- NCT02151058
- Testing
- Colgate® Regular Cavity Protection, Experimental Mouth Rinse, Crest® 3D White Multi-Care Whitening Rinse, Glamorous White, Fresh Mint
- Where
- United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Dental Plaque
Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse
Calibration study to determine the anit-plaque efficacy of commerical toothpastes and an oral rinse
- Trial name
- NCT01024738
- Testing
- Fluoride, Triclosan, fluoride, Chlorhexidine Gluconate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Xerostomia
Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects
The purpose of this study is to investigate the consumer perception of an experimental mouthwash formulation in population with dry mouth
- Trial name
- NCT03005041
- Testing
- Biotene mouthwash, Bottled mineral water
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dentin Sensitivity
A Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
This study is for people with sensitive teeth and involves going to the dentist for 4 visits over 6 weeks. At each visit the dentist will look at the mouth, teeth, tongue and gums of subjects, and check for sensitive teeth.
- Trial name
- NCT01727258
- Testing
- Mouth Rinse, Fluoride Toothpaste, Potassium Nitrate Toothpaste
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Oral Malodor
Controlling Oral Malodor by ClōSYS Oral Rinse
The purpose of this Study is to assess the efficacy of two ClōSYS Oral Rinse products in human subjects in controlling oral malodor in partial fulfillment of the requirements for recognition by the American Dental Association's…
- Trial name
- NCT03160573
- Testing
- ClōSYS® Unflavored Rinse, ClōSYS® Flavored Rinse
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Rowpar Pharmaceuticals, Inc.
Oral Mucosal Disorder
3M Oral Rinse Incidence and Patient Acceptance of Sloughing When Used With Sodium Lauryl Sulfate (SLS) Toothpastes
The primary objective of this study is to evaluate the incidence of oral tissue sloughing through self-report by study subjects and by professional dental examinations.
- Trial name
- NCT04601103
- Testing
- No SLS toothpaste, Medium SLS toothpaste, High SLS toothpaste
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Plaque
A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Rinse contains an anti-plaque agent that helps prevent the accumulation of dental plaque associated with gingivitis.
- Trial name
- NCT03421145
- Testing
- 3M™ Oral Rinse, Vehicle Control Oral Rinse, PerioShield™ Oral Health Rinse
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Dental Plaque, Gingivitis
The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis
The objective of this clinical research study is to assess the efficacy of three oral hygiene multi-component regimens encompassing the use of a manual toothbrush, toothpaste and a mouthwash in controlling established dental…
- Trial name
- NCT02193165
- Testing
- triclosan/fluoride toothpaste + cetylpyridinium chloride Mouthwash, stannous fluoride toothpaste + cetylpyridinium chloride Mouthwash, fluoride toothpaste + fluoride Mouthwash
- Where
- Puerto Rico
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Health
Oral Tissue Tolerance of a Mouthrinse
This study is 8 weeks long. People participating in this study will be asked to brush their teeth two times a day. Some people will get a mouthwash. People with a mouthwash will rinse two times a day after brushing their teeth.
- Trial name
- NCT01009554
- Testing
- Potassium Oxylate Mouthwash, Sodium Fluoride Dentifrice
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Dentin Sensitivity
A Study to Investigate Efficacy of Two Experimental Oral Rinses in Providing Long Term Relief From Pain Derived From Exposed Dentine in Response to Chemical, Thermal, Tactile, or Osmotic Stimuli.
This will be a single center, eight week, randomized, double blind, three treatment arm, parallel design, stratified (by mean baseline Schiff Sensitivity Score of the two selected test teeth) study in healthy participants.
- Trial name
- NCT02651467
- Testing
- Experimental Oral Rinse 1 (1.5% w/w KOX, 0ppm F, pH 7.0), Experimental Oral Rinse 2 (2.0% w/w KOX, 45ppm F, pH 4.5)
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Plaque, Gingivitis
Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)
The objective of this clinical research study is to assess the efficacy of a commercially available triclosan/copolymer toothpaste compared to a commercially available oral hygiene multi-component regimen encompassing the use of…
- Trial name
- NCT02366689
- Testing
- Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque
Clinical Research Study Efficacy of a Prototype Oral Rinse
Evaluate the efficacy of an oral rinse on dental plaque and gingival inflammation
- Trial name
- Quigley (NCT01021007)
- Testing
- Iodine, water
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dentin Sensitivity
Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
This study is for people with sensitive teeth and involves going to the dentist for 4 visits over 6 weeks. At each visit the dentist will look at the mouth, teeth, tongue and gums of participants, and check for sensitive teeth.
- Trial name
- NCT02113579
- Testing
- Experimental Mouth Rinse 12027-033
- Where
- 2 sites in United States
- Volunteers
- 375 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Head and Neck Neoplasms, Mucositis
Study of the Effects of Brilacidin Oral Rinse on Radiation-induced Oral Mucositis in Patients With Head and Neck Cancer
Oral Mucositis (OM) is a painful and debilitating side effect of many of the drug/radiation regimens used to treat cancer. This study examines the investigational drug brilacidin and its possible application in prevention of oral…
- Trial name
- Brilacidin (NCT02324335)
- Testing
- Brilacidin
- Where
- 16 sites in United States
- Volunteers
- 61 people
- Sponsor
- Innovation Pharmaceuticals, Inc.
Oral Malodor
Controlling Oral Malodor by ClōSYS® Oral Rinse
The purpose of this Study is to assess the efficacy of two ClōSYS Oral Rinse products in human subjects in controlling oral malodor in partial fulfillment of the requirements for American Dental Association's (ADA) requirement…
- Trial name
- NCT03160560
- Testing
- ClōSYS® Unflavored Rinse, ClōSYS® Flavored Rinse
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rowpar Pharmaceuticals, Inc.
Dentin Sensitivity
Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity
The aim of this study is to investigate the longitudinal efficacy of a potassium nitrate mouthwash formulation when used as an adjunct to brushing with a standard fluoride dentifrice for the relief of dentinal hypersensitivity…
- Trial name
- NCT02226562
- Testing
- Potassium nitrate and sodium fluoride, Standard fluoride dentifrice
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Xerostomia
Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms
This will be a single center, 7-day, examiner blind, two treatment-arm, randomized, stratified (Sjogren's Syndrome status [Y/N]), parallel group study conducted in participants experiencing dry mouth symptoms.
- Trial name
- NCT02641912
- Testing
- Biotene mouthwash, Mineral Water
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline