Clinical trials: Mouthwashes
Dental Plaque
Evaluating Commercial Anti-Plaque Products and Oral Rinse
Clinical research study to determine the anti-plaque efficacy of commerical dentifrices and an oral rinse.
- Trial name
- NCT01014143
- Testing
- Fluoride, Chlorhexidine digluconate, Fluoride, triclosan
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Periodontal Disease, Periodontal Disease Stage 2
ABX Versus CHX in NSPT
The study aims to compare the efficacy of a novel mouthwash based on microRepair ABX and an antibacterial complex with that of 0.12% chlorhexidine, both used as adjuncts to scaling and root planing.
- Conditions
- Periodontal Disease, Periodontal Disease Stage 2, Periodontal Disease, AVDC Stage 3
- Trial name
- ABXvsCHX (NCT07520968)
- Testing
- ABX Mouthwash as adjunctive to non surgical periodontal treatment, CHX as adjunctive to non surgical periodontal treatment
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Oral Biofilm, Mouthwash
Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth.
The accumulation and maturation of oral biofilm in the gingival margin is widely recognised to be the primary aetiological factor in the development of chronic gingivitis.
- Conditions
- Oral Biofilm, Mouthwash, Periodontitis
- Trial name
- NCT02124655
- Testing
- Essential oils, 0.2% chlorhexidine, Sterile water
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Viral Pharyngitis
Effect of Cetylpyridinium Chloride (CPC) Rinse in Viral Upper Respiratory Tract Infections (vURTI)
This is a randomized, controlled clinical trial with two parallel groups in which 150 volunteers (75 per group) will receive either VITIS CPC Protect® mouthwash (Mouthwash with cetylpyridinium chloride (CPC) as an anti-plaque…
- Trial name
- NCT06251089
- Testing
- CPC mouthwash
- Where
- Spain
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Dentaid SL
Dentin Sensitivity
A Test on a New Experimental Mouth Rinse for Relieving Tooth Sensitivity
This study is for people with sensitive teeth and involves going to the dentist for 4 visits over 6 weeks. At each visit the dentist will look at the mouth, teeth, tongue and gums of subjects, and check for sensitive teeth.
- Trial name
- NCT01727258
- Testing
- Mouth Rinse, Fluoride Toothpaste, Potassium Nitrate Toothpaste
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Dietary Supplement, Sports Performance
Caffeine Mouth Rinsing at Different Doses in Female Team-Sport Athletes: A Randomized, Double-Blind, Placebo-Controlled Trial
Objective: To evaluate the effects of different caffeine mouth rinse concentrations (1%, 2%, and 3%) on Running Anaerobic Sprint Test (RAST) performance in female team-sport athletes. Main Questions: 1.
- Trial name
- MORISINGFEMALE (NCT07129863)
- Testing
- Experimental: Low mouth rinse caffeine concentration (1%), Moderate caffeine concentration (2% caffeine solution weight/volume)., High caffeine concentration (3% caffeine solution weight/volume).
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universidad Pontificia Comillas
High Caries Risk Patients, Caries
Caries Prevention and Side Effects of Gum Arabic and Licorice Extracts Versus Chlorhexidine in High Caries Risk Patients
This trial is to test the caries prevention effect of Arabic gum and Licorice root extracts compared to Chlorhexidine in high caries risk patients.
- Conditions
- High Caries Risk Patients, Caries, Antimicrobial Effect, Side Effect
- Trial name
- NCT03684993
- Testing
- Arabic, Gum, Licorice Root, Chlorhexidine
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cairo University
covid19
Evaluation of the Efficacy of Mouth Rinses With Commercial Mouthwashes to Decrease Viral Load in Saliva in COVID-19 Patients
As no curative treatment for SARS-CoV-2 is currently available, most public health measures to contain the pandemic are based on preventing the spread of the pathogen.
- Trial name
- NCT05543603
- Testing
- Lacer Clorhexidina Colutorio, Lacer Clorhexidine 0.20% Colutorio, Gingilacer Encías Delicadas Colutorio
- Where
- 4 sites in Spain
- Volunteers
- 48 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Oral Hygiene, Oral Health
Antibacterial Effect of Ozonated Olive Oil, Propolis and Chlorhexidine Mouthwashes in Pediatric Patients
Streptococcus mutans and Lactobacillus acidophilus are the most common cariogenic microorganisms. Chlorhexidine has been the most widely used antibacterial mouthwash in dentistry.
- Trial name
- NCT07197073
- Testing
- Ozonated olive oil, Propolis, Chlorhexidine
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- Alexandria University
Halitosis
The Efficacy of Oregano Essential Oil in Reducing Oral Halitosis
the efficacy of commercially available oregano essential oil mouthwash in the reduction of oral halitosis was compared to chlorhexidine and distilled water and the results showed significant reduction of organoleptic tongue and…
- Trial name
- NCT04779502
- Testing
- oregawash, corsodyl
- Where
- Iraq
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- MOHAMED SAEED M. ALI
Cystic Fibrosis, Infection
Anti-pseudomonas IgY to Prevent Infections in Cystic Fibrosis
Hypothesis: Daily gargling with specific avian antibodies against Pseudomonas aeruginosa will prevent infections with this bacteria in patients with Cystic fibrosis (CF).
- Conditions
- Cystic Fibrosis, Infection, Pseudomonas Aeruginosa
- Trial name
- PseudIgY (NCT00633191)
- Testing
- Anti-pseudomonas IgY gargle
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Immunsystem AB
Plaque Score, Gingival Health
Effectiveness of Herbal vs Chlorhexidine Mouthwashes in Improving Oral Health in Schoolchildren
Dental plaque and gingivitis are common oral health problems among school children. Mechanical plaque control, such as tooth brushing, is essential but may be insufficient for maintaining optimal oral hygiene.
- Conditions
- Plaque Score, Gingival Health, Streptococcus Mutans
- Trial name
- NCT07309679
- Testing
- Chlorhexidine Digluconate 0.2% Mouthwash, Pomegranate Peel Extract Mouthwash, Neem Extract Mouthwash
- Where
- Egypt
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Recurrent Aphthous Ulcer, Recurrent Aphthous Stomatitis
Effectiveness of Recurrent Aphthous Stomatitis Mouthwash System for the Treatment of Oral Ulcers
The purpose of the present research is to evaluate the efficacy of a gel formulation for a total treatment of 14 days for the treatment of traumatic or aphthous oral ulcers.
- Trial name
- RASMA (NCT07121361)
- Testing
- Mouthwash Product, Control
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants, Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants
Ibuprofen Inhibits Human Sweet Taste
The sweet taste receptor, TAS1R2-TAS1R3, is expressed both orally, where it signals sweet taste, and extraorally in the intestine and pancreas, where it may affect glucose absorption and metabolism.
- Trial name
- NCT06291337
- Testing
- Inhibition of Sweet Taste by Ibuprofen Oral Rinses, Inhibition of Sweet Taste by Naproxen Oral Rinses
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy
A Study of Virtually Supervised Mouthwash and Interdental Brushes
The purpose of this study is to assess the relative effectiveness of oral (mouth) care regimens for the avoidance and treatment of plaque and gingivitis.
- Trial name
- NCT05756673
- Testing
- Colgate Cavity Protection Toothpaste, LISTERINE ZERO Alcohol Mouthwash COOL MINT, LISTERINE COOL MINT Antiseptic Mouthwash
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Dental Plaque, Gingivitis
Preliminary Evidence of the Efficacy of a Mouthwash Containing 5% Propolis for the Control of Plaque and Gingivitis
Mouthwash based on medicinal plants and propolis can be easily found in the Brazilian market even if it has not been tested in reliable clinical trials on its efficacy or possible unpleasant side effects like the ones which alter…
- Trial name
- MGP (NCT01142843)
- Testing
- green propolis mouthwash
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Federal University of Minas Gerais
Periodontal Diseases, Periodontitis
Inflammation-resolution Therapy in MINST of Periodontal Intrabony Defect: a Pilot Randomised Controlled Trial
The aim of this study is to assess whether and how a mouthwash containing an ingredient that reduces inflammation in combination with a recently developed treatment is more effective at improving advanced gum disease.
- Trial name
- AIRTIM (NCT07203872)
- Testing
- IsoDent Paro Strong (Isodent Ltd. Valtakatu 4 D, 96100 Rovaniemi, Finland) mouthwash
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chlorhexidine, Ventilator Associated Pneumonia
Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0%
This study will assess the utility of different chlorhexidine mouthwash concentrations on ICU patients to decolonize their oral cavities from gram-negative bacteria, since this is a non-desirable condition that leads to higher…
- Trial name
- NCT03442023
- Testing
- Chlorhexidine gluconate at 2%, Chlorhexidine gluconate at 0.12%
- Where
- Mexico
- Volunteers
- 74 people
- Sponsor
- Universidad de Guanajuato
Esophageal Adenocarcinoma, Barrett's Esophagus
Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome
This is a randomized, open-label pilot study to assess whether treatment with chlorhexidine mouthwash can alter the esophageal and gastric cardia microbiome
- Conditions
- Esophageal Adenocarcinoma, Barrett's Esophagus, Reflux Esophagitis
- Trial name
- Mouthwash (NCT02513784)
- Testing
- Chlorhexidine gluconate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Gingivitis
Protocol Efficacy of Mouthwashes in Experimental Gingivitis
This research was performed to find out the clinical efficacy and the anti-plaque and anti-gingivitis properties of a new oral health product (mouthwash and oral gel; StellaLife) compared to chlorhexidine.
- Trial name
- NCT07270952
- Testing
- StellaLife, Chlorhexidine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Stony Brook University